Experimental drug aims to help hearts damaged by protein clumps
NCT ID NCT05442047
Summary
This study tested whether a new medicine called NNC6019-0001 could help people with a specific heart condition where abnormal proteins build up in the heart muscle. About 105 adults with moderate heart symptoms received either the experimental medicine or a placebo through monthly infusions for over a year. Researchers measured changes in how far participants could walk in 6 minutes and tracked heart-related blood markers to see if the treatment was effective and safe.
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Contacts and locations
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Locations
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Ap-Hp-Hopital Henri Mondor
Créteil, 94000, France
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Cedars-Sinai Medical Center_Los Angeles
Beverly Hills, California, 90211, United States
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Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil
Toulouse, 31059, France
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Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1
Toulouse Cedex 9 TSA 50032, 31059, France
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Centro per lo Studio e la Cura delle Amiloidosi Sistemiche Fondazione IRCCS Policlinico San Matteo
Pavia, PV, 27100, Italy
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Ctr for Cardiovascular Innovation
Vancouver, British Columbia, V5Z 1M9, Canada
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Fondazione Toscana Gabriele Monasterio - Dipartimento Cardiotoracico - UOC Cardiologia e Medicina Cardiovascolare
Pisa, Pi, 56124, Italy
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Hiroshima University hospital, Cardiovascular Medicine
Hiroshima, 734-8551, Japan
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Hiroshima University hospital_Cardiovascular Medicine
Hiroshima, 734-8551, Japan
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Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, 28222, Spain
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Hospital Universitario Puerta de Hierro Majadahonda
Madrid, 28222, Spain
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Hospital da Senhora da Oliveira - Guimarães
Guimarães, 4835-044, Portugal
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Hospital of the University of Occupational and Environmental Health
Fukuoka, 807-8556, Japan
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Hospital of the University of Occupational and Environmental Health, Cardiology, Nephrology
Fukuoka, 807-8556, Japan
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II. interni klinika VFN - Kardiologie a angiologie
Prague, 12808, Czechia
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Kumamoto University Hospital, Cardiovascular Medicine
Kumamoto-shi, Kumamoto, 860-8556, Japan
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LMU Klinikum München Klinik und Poliklinik 1
München, 81377, Germany
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Mayo Clinic Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic Jacksonville
Jacksonville, Florida, 32224, United States
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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NW Univ-Bluhm Cardiovasc Inst
Evanston, Illinois, 60208, United States
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Nagasaki University Hospital, Cardiovascular Medicine
Nagasaki, 852-8501, Japan
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Okayama University Hospital_Cardiovascular Medicine
Okayama-shi, Okayama, 700-8558, Japan
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Oregon Hlth Sci Univ-Portland
Portland, Oregon, 97239-4501, United States
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Shinshu University Hospital, Department of Neurology
Nagano, 390-8621, Japan
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Stanford Hlth Cre-Boswell Clin
Stanford, California, 94305, United States
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ULS De Tras-Os-Montes E Alto Douro E.P.E. - Unidade Hospitalar de Vila Real
Vila Real, 5000-508, Portugal
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ULS Do Alto Ave, E.P.E. - Hospital Senhora da Oliveira - Guimarães
Guimarães, 4835-044, Portugal
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UMC Groningen
Groningen, 9713 GZ, Netherlands
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UMC Groningen afdeling Cardiologie
Groningen, 9713 GZ, Netherlands
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Unidade Local de Saude do Alto Ave, E.P.E.
Guimarães, 4835-044, Portugal
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UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie
Heidelberg, 69120, Germany
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Univ of MD Schl of Med
Baltimore, Maryland, 21201, United States
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Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
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Universitatsklinikum Wurzburg AöR
Würzburg, 97078, Germany
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Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz
Würzburg, 97078, Germany
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University of Calgary_Cardiology
Calgary, Alberta, T2N 4Z6, Canada
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University of Maryland School of Medicine
Baltimore, Maryland, 21201, United States
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Universitätsklinikum Münster - Klinik für Kardiologie I
Münster, 48149, Germany
Conditions
Explore the condition pages connected to this study.