Intensive chemo tandem may boost survival in kids with brain cancer

NCT ID NCT02875314

Ongoing Disease control Sponsor: Parth Patel Source: ClinicalTrials.gov ↗

First seen Feb 20, 2026 · Last updated May 10, 2026 · Updated 7 times

Summary

This study tests whether giving three rounds of high-dose chemotherapy with stem cell rescue works better than one round for children under 10 with high-risk brain tumors. The goal is to improve survival without adding too many side effects. About 250 children will take part, and the treatment is tailored to each child's tumor type.

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Contacts and locations

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Locations

Akron Children's Hospital

Akron, Ohio, 44308, United States
Alberta Children's Hospital

Calgary, Canada
American Family Children's Hospital/University of Wisconsin

Madison, Wisconsin, 53792, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
B.C. Children's Hospital

Vancouver, British Columbia, V6H 3V4, Canada
Carolina's HealthCare System/Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Central Michigan University

Detroit, Michigan, 48201, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30342, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital Orange County

Orange, California, 91868, United States
Children's Hospital of Minnesota

Minneapolis, Minnesota, 55404, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Children's Specialty Care of Nevada

Las Vegas, Nevada, 89135, United States
Children's of Alabama

Birmingham, Alabama, 35233, United States
Christchurch Children's Hospital

Christchurch, New Zealand
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Columbia Presbyterian Children's Hospital

New York, New York, 10032, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dayton Children's Hospital

Dayton, Ohio, 45404, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Hamilton Health/McMasters Children's Hospital, Hamilton, Canada

Hamilton, Canada
Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
John's Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
John's Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States
Joseph Sanzari Children's Hospital/ Hackensack University

Hackensack, New Jersey, 07601, United States
Loma Linda University Medical Center

Loma Linda, California, 92350, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Masonic Children's Hospital/University of Minnesota

Minneapolis, Minnesota, 55454, United States
Mattel Children's Hospital (UCLA)

Los Angeles, California, 90095, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 58226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Care Health Services

Long Beach, California, 90806, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Morristown Medical Center, Atlantic Health System

Morristown, New Jersey, 07960, United States
NYU Langone Medical Center

New York, New York, 10016, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Nemours Center for Cancer and Blood Disorders

Wilmington, Delaware, 19803, United States
Nemours Center for Cancer and Blood Disorders

Jacksonville, Florida, 19803, United States
New York Medical College

Hawthorne, New York, 10532, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Northwell Health

Hempstead, New York, 11549, United States
Orlando Health

Orlando, Florida, 32806, United States
Penn State Hershey Children's Hospital

Hershey, Pennsylvania, 17033, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
Primary Children's Hospital

Salt Lake City, Utah, 84113, United States
Rainbow Babies & Children's Hospital

Cleveland, Ohio, 44106, United States
Riley Children's Hospital/University of Indiana

Indianapolis, Indiana, 46202, United States
Shands Children's Hospital/ University of FL

Gainesville, Florida, 32608, United States
Starship Children's Hospital

Auckland, New Zealand
Stollery Children's Hospital

Edmonton, Canada
The Hospital of Sick Children

Toronto, Canada
UCSF Oakland Benioff

Oakland, California, 94609, United States
University of Iowa Hospital and Clinics

Iowa City, Iowa, 52242, United States
University of Louisville School of Medicine

Louisville, Kentucky, 40202, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
Upstate Golisano Children's Hospital/ SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University

Richmond, Virginia, 23219, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS MEDULLOBLASTOMA