Major cancer trial tests gentler chemo schedule

NCT ID NCT05050162

Terminated Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

Summary

This study aims to find out if giving a common chemotherapy drug (cisplatin) weekly alongside radiation is easier for patients to tolerate than giving it every three weeks. It will also check if the weekly schedule is at least as good at helping patients live longer. The trial involves over 1,700 adults with advanced head and neck cancer that has not spread to distant organs.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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AdventHealth Littleton

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Allan Blair Cancer Centre

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American Fork, Utah, 84003, United States
Aspirus Cancer Care - James Beck Cancer Center

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Augusta University Medical Center

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Centerville, Ohio, 45459, United States
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Decatur, Illinois, 62526, United States
Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154, United States
Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States
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Seattle, Washington, 98133, United States
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Pinehurst, North Carolina, 28374, United States
Forbes Hospital

Monroeville, Pennsylvania, 15146, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
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Joplin, Missouri, 64804, United States
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Fresno, California, 93720, United States
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Menomonee Falls, Wisconsin, 53051, United States
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West Bend, Wisconsin, 53095, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States
Genesys Hurley Cancer Institute

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O'Fallon, Illinois, 62269, United States
Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States
Henry Ford Health Providence Novi Hospital

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Dearborn, Michigan, 48126, United States
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West Bloomfield, Michigan, 48322, United States
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Havre, Montana, 59501, United States
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Rochester, New York, 14620, United States
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Houston, Texas, 77030, United States
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Houston Methodist San Jacinto Hospital

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Houston Methodist Sugar Land Hospital

Sugar Land, Texas, 77479, United States
Houston Methodist The Woodlands Hospital

The Woodlands, Texas, 77385, United States
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Houston, Texas, 77094, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
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Washington, Illinois, 61571, United States
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Canton, Illinois, 61520, United States
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Pekin, Illinois, 61554, United States
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Peru, Illinois, 61354, United States
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Princeton, Illinois, 61356, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Inova Alexandria Hospital

Alexandria, Virginia, 22304, United States
Inova Fair Oaks Hospital

Fairfax, Virginia, 22033, United States
Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States
Intermountain Medical Center

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Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Kaiser Permanente Cancer Treatment Center

South San Francisco, California, 94080, United States
Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States
Kaiser Permanente Dublin

Dublin, California, 94568, United States
Kaiser Permanente Fresno Orchard Plaza

Fresno, California, 93720, United States
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Los Angeles, California, 90027, United States
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Santa Clara, California, 95051, United States
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Vacaville, California, 95688, United States
Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States
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San Leandro, California, 94577, United States
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Redwood City, California, 94063, United States
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Anaheim, California, 92806, United States
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Bellflower, California, 90706, United States
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Antioch, California, 94531, United States
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Denver, Colorado, 80205, United States
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Fremont, California, 94538, United States
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Fresno, California, 93720, United States
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Irvine, California, 92618, United States
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Lone Tree, Colorado, 80124, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Ontario

Ontario, California, 91761, United States
Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-Rock Creek

Lafayette, Colorado, 80026, United States
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Roseville, California, 95661, United States
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San Jose, California, 95119, United States
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Sacramento, California, 95823, United States
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South San Francisco, California, 94080, United States
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Stockton, California, 95210, United States
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Walnut Creek, California, 94596, United States
Kaiser San Rafael-Gallinas

San Rafael, California, 94903, United States
Kantonsspital Aarau

Aarau, 5001, Switzerland
Kettering Medical Center

Kettering, Ohio, 45429, United States
LDS Hospital

Salt Lake City, Utah, 84143, United States
Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States
Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Logan Regional Hospital

Logan, Utah, 84321, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Lutheran Hospital - Cancer Centers of Colorado

Golden, Colorado, 80401, United States
MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States
MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - Sanford

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States
MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530, United States
MaineHealth Maine Medical Center - Biddeford

Biddeford, Maine, 04005, United States
MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102, United States
MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Maryland Proton Treatment Center

Baltimore, Maryland, 21201, United States
McKay-Dee Hospital Center

Ogden, Utah, 84403, United States
MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Medical Center

Modesto, California, 95355, United States
Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States
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Elk Grove, California, 95758, United States
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Rocklin, California, 95765, United States
Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
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Springfield, Missouri, 65804, United States
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Des Moines, Iowa, 50314, United States
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West Des Moines, Iowa, 50266, United States
Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
Methodist Willowbrook Hospital

Houston, Texas, 77070, United States
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Cleveland, Ohio, 44109, United States
Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States
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Dayton, Ohio, 45409, United States
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Dayton, Ohio, 45415, United States
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Centerville, Ohio, 45459, United States
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Houston, Texas, 77030, United States
Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346, United States
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Farmington Hills, Michigan, 48334, United States
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Macomb, Michigan, 48044, United States
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Madison Heights, Michigan, 48071, United States
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Pontiac, Michigan, 48341, United States
Michigan Healthcare Professionals Troy

Troy, Michigan, 48098, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Mobile Infirmary Medical Center

Mobile, Alabama, 36607, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States
Moffitt Cancer Center at Wesley Chapel

Wesley Chapel, Florida, 33544, United States
Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, 72401, United States
Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
Novant Cancer Institute Radiation Oncology - Supply

Supply, North Carolina, 28462, United States
Novant Health Cancer Institute Radiation Oncology - Wilmington

Wilmington, North Carolina, 28401, United States
Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Ottawa Hospital and Cancer Center-General Campus

Ottawa, Ontario, K1H 8L6, Canada
Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States
Palo Alto Medical Foundation Health Care

Palo Alto, California, 94301, United States
Palo Alto Medical Foundation-Camino Division

Mountain View, California, 94040, United States
Palo Alto Medical Foundation-Fremont

Fremont, California, 94538, United States
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Sunnyvale, California, 94086, United States
Pamela Youde Nethersole Eastern Hospital

Chai Wan, Hong Kong
Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States
Premier Blood and Cancer Center

Dayton, Ohio, 45409, United States
ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606, United States
Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States
Riverton Hospital

Riverton, Utah, 84065, United States
Rohnert Park Cancer Center

Rohnert Park, California, 94928, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush-Copley Medical Center

Aurora, Illinois, 60504, United States
Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint George Regional Medical Center

St. George, Utah, 84770, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint Joseph Hospital

Lexington, Kentucky, 40504, United States
Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States
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Lexington, Kentucky, 40509, United States
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Lexington, Kentucky, 40504, United States
Saint Lukes Hospital

Dublin, Co Dublin, 6, Ireland
Saint Vincent Hospital

Erie, Pennsylvania, 16544, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
South Sacramento Cancer Center

Sacramento, California, 95823, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Stanford Cancer Center South Bay

San Jose, California, 95124, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Summa Health Medina Medical Center

Medina, Ohio, 44256, United States
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Akron, Ohio, 44304, United States
Summa Health System - Barberton Campus

Barberton, Ohio, 44203, United States
Sutter Auburn Faith Hospital

Auburn, California, 95602, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Pacific Medical Foundation

Santa Rosa, California, 95403, United States
Sutter Roseville Medical Center

Roseville, California, 95661, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Angeles Clinic and Research Institute - West Los Angeles Office

Los Angeles, California, 90025, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States
Tower Cancer Research Foundation

Beverly Hills, California, 90211, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States
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Chelsea, Michigan, 48118, United States
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Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
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Canton, Michigan, 48188, United States
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Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UC Irvine Health Cancer Center-Newport

Costa Mesa, California, 92627, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UC San Diego Health System - Encinitas

Encinitas, California, 92024, United States
UC San Diego Medical Center - Hillcrest

San Diego, California, 92103, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UH Seidman Cancer Center at UH Avon Health Center

Avon, Ohio, 44011, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UM Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Doral

Doral, Florida, 33166, United States
UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114, United States
University College Hospital Galway

Galway, Co Galway, Ireland
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Hospitals Portage Medical Center

Ravenna, Ohio, 44266, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States
Utah Valley Regional Medical Center

Provo, Utah, 84604, United States
VA Palo Alto Health Care System

Palo Alto, California, 94304, United States
Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, North Carolina, 28659, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States
Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090, United States
William S Middleton VA Medical Center

Madison, Wisconsin, 53705, United States
Wilmot Cancer Institute at Webster

Webster, New York, 14580, United States
Woodland Memorial Hospital

Woodland, California, 95695, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA ADVANCED HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA ADVANCED LARYNGEAL SQUAMOUS CELL CARCINOMA ADVANCED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA CLINICAL STAGE III HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 CLINICAL STAGE IV HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 STAGE III HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE III OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IV HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE IV OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8