Major trial halted: did new drug boost cancer survival?
NCT ID NCT04459715
Summary
This large study aimed to see if adding an experimental drug called Xevinapant to standard chemoradiation treatment could better control locally advanced head and neck cancer and help patients live longer without the cancer returning. It involved 730 adults with newly diagnosed, HPV-negative cancers of the throat, voice box, or hypopharynx who were eligible for intensive chemoradiation. The trial compared the standard treatment plus Xevinapant against the standard treatment plus a placebo.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
A.Z. Nikolaas
Sint-Niklaas, Belgium
-
AORN Ospedale dei Monaldi
Naples, Italy
-
AOU "Luigi Vanvitelli"
Naples, Italy
-
ASCLEPES Research Centers
Weeki Wachee, Florida, 34607, United States
-
ASL2_Presidio Ospedaliero San Paolo
Savona, Italy
-
Aberdeen Royal infirmary, Dept. of Oncology
Aberdeen, United Kingdom
-
Academician Fridon Todua Medical Center-Ltd Research Institute of Clinical Medicine
Tbilisi, Georgia
-
Affiliated Tumor Hospital of Guangxi Medical University
Nanning, China
-
Agioi Anargiroi General Oncology Hospital of Kifissia
Athens, Greece
-
Althaia, Xarxa Assistencial
Manresa, Spain
-
Asan Medical Center
Seoul, South Korea
-
Asan Medical Center, Asian Cacer Center
Seoul, South Korea
-
Ashford Cancer Centre Research, Tennyson Centre
Adelaide, Australia
-
Ashland-Bellefonte Cancer Center
Ashland, Kentucky, 41101, United States
-
Attikon University Hospital
Athens, Greece
-
Az. USL 6 Ospedali Riuniti-Ospedale di Livorno
Livorno, Italy
-
Azienda Ospedaliero Universitaria di Parma
Parma, Italy
-
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
-
Azienda Sanitaria Ospedaliera Santa Croce e Carle - Oncologia Medica -Ospedale Carle
Cuneo, Italy
-
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia
Brescia, Italy
-
Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
-
Beijing Cancer Hospital
Beijing, China
-
Beth Israel Deaconess (BI Lahey)/Harvard Cancer Center
Boston, Massachusetts, 02215, United States
-
CAMPUS CHARITÉ MITTE, Klinik f.Strahlentherapie
Berlin, Germany
-
CCConcorde (GCS)
Neuilly-sur-Seine, France
-
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - FMABC - Faculdade de Medicina do ABC
Santo André, Brazil
-
CHP Saint Gregoire FINESS
Saint-Grégoire, France
-
CHRU de Brest Hopital Morvan
Brest, France
-
CHU Amiens Picardie - Hopital Sud
Amiens, France
-
CHU Montréal
Montreal, Canada
-
CHU Nimes
Nîmes, France
-
CHU UCL Namur Site Sainte Elisabeth
Namur, Belgium
-
CHU de Grenoble
Grenoble, France
-
CHU de Quebec-Université Laval
Québec, Canada
-
CHU de Tours
Tours, France
-
CIUSSS de l'Est de l'Ile de Montreal - Hopital Maisonneuve-Rosemont
Montreal, Canada
-
Cancer Institute Hospital of JFCR
Kōtoku, Japan
-
Cancer Research Cent 4
Tbilisi, Georgia
-
Centre Antoine Lacassagne
Nice, France
-
Centre Eugène Marquis
Rennes, France
-
Centre Guillaume Le Conquerant
Le Havre, France
-
Centre Henri Becquerel CLCC
Rouen, France
-
Centre Hospitalier Universitaire Vaudois Lausanne
Lausanne, Switzerland
-
Centre Hospitalier de l'Ardenne (CHA)
Libramont, Belgium
-
Centre Jean Perrin CLCC
Clermont-Ferrand, France
-
Centre Leon Berard
Lyon, France
-
Centre Oscar Lambret
Lille, France
-
Centre hospitalier Libourne
Libourne, France
-
Centre hospitalier Universitaire de Bordeaux
Bordeaux, France
-
Centro Clinico Academico
Braga, Portugal
-
Centro Gaúcho Integrado, Rua Costa
Porto Alegre, Brazil
-
Centro Hospitalar Universitario São João
Porto, Portugal
-
Centro Hospitalar Universitário Lisboa Norte
Lisbon, Portugal
-
Centro Hospitalar Universitário do Algarve - Hospital de Faro (PRT)
Faro, Portugal
-
Centro Hospitalar de Vila Nova de Gaia/Espinho
Porto, Portugal
-
Centro di Riferimento Oncologico
Aviano, Italy
-
Centrum Onkologii- Instytut im. Marii Sklodowskiej-Curie Oddzial w Gliwicach
Gliwice, Poland
-
Chang Gung Medical Foundatoin Linkou Chang Gung Memorial Hospital
Taoyuan, Taiwan
-
Chang-Gung Memorial Hospital-Kaohsiung
Kaohsiung City, Taiwan
-
Charing Cross Hospital
London, United Kingdom
-
Charité - Universitätsmedizin Berlin Campus Virchow
Berlin, Germany
-
China Medical University Hospital
Taichung, Taiwan
-
Clatterbridge Cancer Centre NHS Foundation Trust
Metropolitan Borough of Wirral, United Kingdom
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
-
Clinica Universidad de Navarra
Madrid, Spain
-
Clinica Universidad de Navarra
Pamplona, Spain
-
Clinica Universitaria Reina Fabiola
Córdoba, Argentina
-
Clinica Viedma
Viedma, Argentina
-
Clinique Victor Hugo
Le Mans, France
-
Cliniques universitaires Saint-Luc
Brussels, Belgium
-
Columbus Regional Research Institute
Columbus, Georgia, 31904, United States
-
Comprehensive Cancer Center of Nevada (Southern Hills) (USA)
Las Vegas, Nevada, 89148, United States
-
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89169, United States
-
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
-
Department of radiation oncology, University Hospital Essen
Essen, Germany
-
EuroCityClinic
Saint Petersburg, Russia
-
Evex Hospitals Oncology Center
Kutaisi, Georgia
-
FGBU N.N.Blokhin Russian Cancer Research Center
Moscow, Russia
-
FSBI National Med Research Cancer Center N.N. Petrov
Saint Petersburg, Russia
-
Fakultni Nemocnice Ostrava
Ostrava-Poruba, Czechia
-
Fondazione Policlinico Universitario Agostino Gemelli
Rome, Italy
-
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
-
Fudan University Shanghai Cancer Center
Shanghai, China
-
Fujian Cancer Hospital
Fuzhou, China
-
Fundacin Oncolgico de Galicia Jos Antonio Quiroga y Pieyro
A Coruña, Spain
-
Fundacio Althaia
Manresa, Spain
-
Fundacion Centro Oncologico de Galicia (COG) "Jose Antonio Quiroga y Pineyro"
A Coruña, Galicia, Spain
-
Fundacion Investigacion Hospital General Universitario de Valencia FiHgU (ESP)
Valencia, Spain
-
Fundação Pio XII- Hospital de Cancer de Barretos, Rua Antenor Duarte Vilela
Barretos, Brazil
-
GZA Sint-Augustinus
Wilrijk, Belgium
-
Gettysburg Cancer Center
Gettysburg, Pennsylvania, 17325, United States
-
Grand Hopital de Charleroi
Charleroi, Belgium
-
Harbin Medical University Cancer Hospital
Harbin, China
-
Henan Cancer Hospital
Zhengzhou, China
-
Henry Ford Health System
Detroit, Michigan, 48202, United States
-
Hokkaido University Hospital
Kita-ku, Japan
-
Hopital Maisonneuve-Rosemont
Montreal, Canada
-
Hopital de Jolimont, Rue Ferrer
La Louvière, Belgium
-
Hopitaux Universitaires de Geneve
Geneva, Switzerland
-
Hospital 12 de Octubre
Madrid, Spain
-
Hospital Aleman
Buenos Aires, Argentina
-
Hospital Civil (Hospital Regional Universitario)
Málaga, Spain
-
Hospital Clinic Barcelona
Barcelona, Spain
-
Hospital Clinico San Carlos
Madrid, Spain
-
Hospital Na Bulovce
Prague, Czechia
-
Hospital Pedro Hispano
Porto, Portugal
-
Hospital Ramon y Cajal
Madrid, Spain
-
Hospital Reina Sofía
Córdoba, Spain
-
Hospital Santa Rita Centro de Pesquisa Clínica Novos Tratamentos Em Câncer
Porto Alegre, Brazil
-
Hospital Santa Rita, Centro de Pesquisa Clínica Novos Tratamentos Em Câncer
Porto Alegre, Brazil
-
Hospital Universitari Vall d'Hebron
Barcelona, Spain
-
Hospital Universitario HM Sanchinarro
Madrid, Spain
-
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, Spain
-
Hospital Universitario La Fe
Valencia, Spain
-
Hospital Universitario La Paz
Madrid, Spain
-
Hospital Universitario Marqués de Valdecilla. Santander
Santander, Spain
-
Hospital de Base de Sao Jose do Rio Preto, Av. Brigadeiro Faria Lima
São José do Rio Preto, Brazil
-
Hospital de Braga
Braga, Portugal
-
Hospital de Caridade de Ijui, Avenida David Jose Martins
Ijuí, Brazil
-
Hospital del Mar
Barcelona, Spain
-
Hunan Cancer Hospital
Changsha, China
-
Hyogo Cancer Center
Hyōgo, Japan
-
Hôpital Nord Franche Comté
Montbéliard, France
-
Hôpital du Scorff
Lorient, France
-
IACT Health, John B. Amos Cancer Center
Columbus, Georgia, 31904, United States
-
ICANS
Strasbourg, France
-
IHO Corporation/Utah Cancer Specialists
Salt Lake City, Utah, 84106, United States
-
IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
Meldola, Italy
-
IRCCS AOU San Martino
Genova, Italy
-
IRCCS-Istituto Europeodi Oncologia The European Institute of Oncology IEO
Milan, Italy
-
IVO
Valencia, Spain
-
Inselspital, Bern University Hospital, Universitätsklinik für Radio-Onkologie
Bern, Switzerland
-
Institut Català d'Oncologia
Girona, Spain
-
Institut Català d'Oncologia Badalona
Barcelona, Spain
-
Institut Català d'Oncologia, Hospital Duran
Barcelona, Spain
-
Institut Claudius Regaud - IUCT-O
Toulouse, France
-
Institut Curie
Paris, France
-
Institut Gustave Roussy - Service de radiotherapie
Villejuif, France
-
Institut Regional du Cancer de Montpellier
Montpellier, France
-
Institut Sainte Catherine
Avignon, France
-
Institut Universitari Dexeus-Quiron (ESP)
Barcelona, Spain
-
Institut de Cancérologie de l Ouest (ICO)
Angers, France
-
Institut de Cancérologie de l'Ouest - Site Saint Herblain
Saint-Herblain, France
-
Institute of Clinical Oncology
Tbilisi, Georgia
-
Instituto Medico Especialazado Alexander Fleming
Buenos Aires, Argentina
-
Instituto Portugues de Oncologia Porto Francisco Gentil, E.P.E
Porto, Portugal
-
Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE
Coimbra, Portugal
-
Instituto de Oncologia de Rosario
Santa Fe, Argentina
-
Instituto do Cancer do Estado de Sao Paulo (ICESP)
São Paulo, Brazil
-
Inventa Center for Cancer Research At Fort Wayne Medical Oncology and Hematology
Fort Wayne, Indiana, 46804, United States
-
Istituto Nazionale Tumori (INT) IRCCS Fondazione "G. Pascale"
Naples, Italy
-
Istituto Nazionale dei Tumori
Milan, Italy
-
Istituto Oncologico Veneto Irccs
Padua, Italy
-
Istituto di Candiolo IRCCS
Candiolo, Italy
-
JSC "Evex Hospitals"
Tbilisi, Georgia
-
Jilin Cancer Hospital
Changchun, China
-
KOC KNTB a.s. Zlín
Zlín, Czechia
-
Kaohsiung Medical University Memorial Hospital
Kaohsiung City, Taiwan
-
Karmanos Cancer institute
Detroit, Michigan, 48302, United States
-
Kiev City Clinical Oncology Centre
Kiev, Ukraine
-
Klinische Abteilung fur Allgemeine HNO Universitatsklinik fur Hals-, Nasen- und Ohrenheilkunde
Graz, Austria
-
Kobe University Hospital
Kobe, Japan
-
KonKuk University Medical Center
Seoul, South Korea
-
Korea University Anam Hospital
Seoul, South Korea
-
Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I.Kryzhanovsky
Krasnoyarsk, Russia
-
Kursk Regional Clinical Oncology Dispensary
Kursk, Russia
-
LEPL First University Clinic of Tbilisi State Medical University
Tbilisi, Georgia
-
LHopital prive du Confluent Nantes
Nantes, France
-
Landeskrankenhaus Salzburg
Salzburg, Austria
-
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, 10016, United States
-
Liaoning Cancer Hospital & institute
Shenyang, China
-
Liga Norte Riograndense Contra o Câncer, Avenida Miguel Castro
Natal, Brazil
-
Lin Yi Cancer Hospital
Shandong, China
-
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
-
London Regional Cancer Program, London Health Sciences Centre
London, Canada
-
MD Anderson
Houston, Texas, 77030, United States
-
Massachusetts General Hospital
Boston, Massachusetts, 02114-2696, United States
-
Medical University of South Carolina- Hollings Cancer Center
Charleston, South Carolina, 29425, United States
-
Medical University of Vienna, Department of Medicine I, Division of Oncology
Vienna, Austria
-
Medical center ASKLEPION LLC
Khodosovka, Ukraine
-
Medical center of Yuriy Spizhenko, Soborna Vulytsia
Kyiv, Ukraine
-
MidAmerica Cancer Care
Kansas City, Missouri, 64114, United States
-
Moffitt Cancer Center
Tampa, Florida, 33612, United States
-
Mount Vernon Cancer Centre
Northwood, United Kingdom
-
NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
-
NYU Grossman School of Medicine
New York, New York, 10016, United States
-
NYU Langone Hospital-Long Island Oncology
Mineola, New York, 11501, United States
-
NZOZ Provita Prolife Centrum Medyczne
Lodz, Poland
-
National Cancer Center
Goyang-si, South Korea
-
National Cancer Center Hematologic Oncology
Goyang-si, South Korea
-
National Cancer Center Hospital
Chuo-ku Tokyo, Japan
-
National Cancer Center Hospital East
Chiba, Japan
-
National Cancer Institute
Rio de Janeiro, Brazil
-
National Hospital Organization Shikoku Cancer Center
Matsuyama, Japan
-
National Taiwan University Hospital
Taipei, Taiwan
-
New Hospitals
Tbilisi, Georgia
-
Norton Cancer Institute, Louisville, Kentucky, Brownsboro Hospital Campus
Louisville, Kentucky, 40241, United States
-
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
-
Ohio State University
Columbus, Ohio, 43210, United States
-
Okayama University Hospital
Kita-ku, Japan
-
Orszagos Onkologiai Intezet Sugarterapias Osztaly
Budapest, Hungary
-
Osaka International Cancer Institute
Osaka, Japan
-
Ospedale "Vito Fazzi" Lecce
Lecce, Italy
-
Oswaldo Cruz German Hospital
São Paulo, Brazil
-
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intazet
Pécs, Hungary
-
Peking Union Medical College Hospital
Beijing, China
-
Peter MacCallum Cancer Centre
Melbourne, Australia
-
Petz Aladár Megyei Kórház Onkoradiológiai Osztály
Győr, Hungary
-
Policlinico di Modena
Modena, Italy
-
Princess Alexandra Hospital, Cancer Trials Unit
Woolloongabba, Australia
-
Providence Portland Medical Center
Portland, Oregon, 97213, United States
-
Pusan National University Hospital
Busan, South Korea
-
Pusan National University Yangsan Hospital, Oncol & Hematology
Yangsan, South Korea
-
Rabin Medical Center
Petach Tiqva, Israel
-
Rambam Healthcare Campus
Haifa, Israel
-
Regents of the University of California
San Francisco, California, 94158, United States
-
Republican Clinical Oncological Dispensary of Bashkortostan
Ufa, Russia
-
Research Fund of the Hadassah Medical Organization
Jerusalem, Israel
-
Royal Marsden NHS Foundation Trust
Chelsea, United Kingdom
-
Royal Surrey County Hospital
Guildford, United Kingdom
-
SP ZOZ MSWiA z W-M CO w Olsztynie
Olsztyn, Poland
-
Saint- Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology)
Saint Petersburg, Russia
-
Saitama Medical University International Medical Center
Hidaka, Japan
-
Seoul National University Boramae Medical Center
Seoul, South Korea
-
Service d'Oncologie Médicale, CHU Timone
Marseille, France
-
Shanghai Ninth People's Hospital
Shanghai, China
-
Shantou University Cancer Hospital
Shantou, China
-
Sheba Medical Center
Ramat Gan, Israel
-
Shizuoka Cancer Center
Nagaizumi-cho, Japan
-
Simon Khechinashvili University Clinic
Tbilisi, Georgia
-
St Vincents Hospital
Darlinghurst, Australia
-
St Vincents Hospital Melbourne
Fitzroy, Australia
-
State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan"
Kazan', Russia
-
State Budgetary Healthcare Institution Republican Clinical Oncology Dispensary (RUS)
Ufa, Russia
-
State Budgetary Institution of Healthcare of Yaroslavl region Clinical oncology hospital
Yaroslavl, Russia
-
Strahlenklinik des Uni-Klinikums
Erlangen, Germany
-
Sunnybrook Research Institute
Toronto, Canada
-
Szegedi Tudományegyetem ÁOK Onkoterápiás Klinika
Szeged, Hungary
-
Szpitale Pomorskie Sp. z o.o.
Gdynia, Poland
-
Taichung Veterans General Hospital
Taichung, Taiwan
-
Taipei Veterans General Hospital (VGHTP)
Taipei, Taiwan
-
The 2nd Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
-
The 5th Affiliated Hospital of Sun yet-sen university
Guangdong, China
-
The Christie NHS Foundation Trust
Manchester, United Kingdom
-
The Oncology Institute of Hope & Innovation
Whittier, California, 90603, United States
-
The Public Hospital L'Institut de Cancerologie de Lorraine
Vandœuvre-lès-Nancy, France
-
The Royal Marsden NHS Foundation Trust - Sutton
Sutton, United Kingdom
-
The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC)
Birmingham, Alabama, 35233, United States
-
Theagenio Anticancer Hospital
Thessaloniki, Greece
-
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
-
Tokai University Hospital
Kanagawa, Japan
-
Tokyo Medical University Hospital
Tokyo, Japan
-
Tongji Hospital/Tongji Medical College, Huazhong University of Science
Wuhan, China
-
UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
-
UCSF
San Francisco, California, 94158, United States
-
UZ Leuven, Radiotherapy & Oncology
Leuven, Belgium
-
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
-
Universitaetsklinikum Jena - Klinik fuer Hals - Nasen und Ohrenheilkunde HNO
Jena, Germany
-
Universitaetsklinikum Regensburg
Regensburg, Germany
-
Universitaetsmedizin Mannheim UMM, Klinik fuer Hals-Nasen-Ohrenheilkunde Kopf- und Halschirurgie
Mannheim, Germany
-
Universitaetsmedizin Rostock
Rostock, Germany
-
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
-
Universitair Ziekenhuis Gent UZ Gent
Ghent, Belgium
-
Universitatsklinikum Leipzig AoR, Klinik für Strahlentherapie
Leipzig, Germany
-
University Hospital Cleveland Medical Center
Cleveland, Ohio, 44106, United States
-
University Hospital Kyoto Prefectural University of Medicine
Kamigyō-ku, Japan
-
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom
-
University Hospital hradec Kralové
Hradec Králové, Czechia
-
University Medical Center Schleswig-Holstein, Campus Kiel
Kiel, Germany
-
University South Hospital
Ann Arbor, Michigan, 48109-9001, United States
-
University of Arizona Cancer Center
Tucson, Arizona, 85724, United States
-
University of Cincinnati Medical Center
Cincinnati, Ohio, 45267, United States
-
University of Colorado at Denver and Health Sciences Center
Aurora, Colorado, 80045, United States
-
University of Missouri - Ellis Fischel Cancer Center
Columbia, Missouri, 65212, United States
-
University of Oklahoma Health Sciences Center- Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
-
University of Virginia Medical Center
Charlottesville, Virginia, 22908, United States
-
Universitätsklinik für Innere Medizin III der PMU
Salzburg, Austria
-
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany
-
Univesitätsklinikum Essen (AöR) Klinikum und Poliklinik für Strahlentherapie
Essen, Germany
-
Uniwersyteckie Centrum Kliniczne - Klinika Onkologii i Radioterapii
Gdansk, Poland
-
Uzsoki Utcai Korhaz Onkologiai Osztaly
Budapest, Hungary
-
Wake Forest University School of Medicine
Winston-Salem, North Carolina, 27157, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
-
West China Hospital of Sichuan University
Chengdu, China
-
Wollongong Hospital
Wollongong, Australia
-
Xiangya Hospital Central South University
Changsha, China
-
Yale Cancer Center
New Haven, Connecticut, 06519, United States
-
Zhejiang Province Cancer Hospital
Hangzhou, China
Conditions
Explore the condition pages connected to this study.