Major trial halted: did new drug boost cancer survival?

NCT ID NCT04459715

Summary

This large study aimed to see if adding an experimental drug called Xevinapant to standard chemoradiation treatment could better control locally advanced head and neck cancer and help patients live longer without the cancer returning. It involved 730 adults with newly diagnosed, HPV-negative cancers of the throat, voice box, or hypopharynx who were eligible for intensive chemoradiation. The trial compared the standard treatment plus Xevinapant against the standard treatment plus a placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • A.Z. Nikolaas

    Sint-Niklaas, Belgium

  • AORN Ospedale dei Monaldi

    Naples, Italy

  • AOU "Luigi Vanvitelli"

    Naples, Italy

  • ASCLEPES Research Centers

    Weeki Wachee, Florida, 34607, United States

  • ASL2_Presidio Ospedaliero San Paolo

    Savona, Italy

  • Aberdeen Royal infirmary, Dept. of Oncology

    Aberdeen, United Kingdom

  • Academician Fridon Todua Medical Center-Ltd Research Institute of Clinical Medicine

    Tbilisi, Georgia

  • Affiliated Tumor Hospital of Guangxi Medical University

    Nanning, China

  • Agioi Anargiroi General Oncology Hospital of Kifissia

    Athens, Greece

  • Althaia, Xarxa Assistencial

    Manresa, Spain

  • Asan Medical Center

    Seoul, South Korea

  • Asan Medical Center, Asian Cacer Center

    Seoul, South Korea

  • Ashford Cancer Centre Research, Tennyson Centre

    Adelaide, Australia

  • Ashland-Bellefonte Cancer Center

    Ashland, Kentucky, 41101, United States

  • Attikon University Hospital

    Athens, Greece

  • Az. USL 6 Ospedali Riuniti-Ospedale di Livorno

    Livorno, Italy

  • Azienda Ospedaliero Universitaria di Parma

    Parma, Italy

  • Azienda Ospedaliero-Universitaria Careggi

    Florence, Italy

  • Azienda Sanitaria Ospedaliera Santa Croce e Carle - Oncologia Medica -Ospedale Carle

    Cuneo, Italy

  • Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia

    Brescia, Italy

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234, United States

  • Beijing Cancer Hospital

    Beijing, China

  • Beth Israel Deaconess (BI Lahey)/Harvard Cancer Center

    Boston, Massachusetts, 02215, United States

  • CAMPUS CHARITÉ MITTE, Klinik f.Strahlentherapie

    Berlin, Germany

  • CCConcorde (GCS)

    Neuilly-sur-Seine, France

  • CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - FMABC - Faculdade de Medicina do ABC

    Santo André, Brazil

  • CHP Saint Gregoire FINESS

    Saint-Grégoire, France

  • CHRU de Brest Hopital Morvan

    Brest, France

  • CHU Amiens Picardie - Hopital Sud

    Amiens, France

  • CHU Montréal

    Montreal, Canada

  • CHU Nimes

    Nîmes, France

  • CHU UCL Namur Site Sainte Elisabeth

    Namur, Belgium

  • CHU de Grenoble

    Grenoble, France

  • CHU de Quebec-Université Laval

    Québec, Canada

  • CHU de Tours

    Tours, France

  • CIUSSS de l'Est de l'Ile de Montreal - Hopital Maisonneuve-Rosemont

    Montreal, Canada

  • Cancer Institute Hospital of JFCR

    Kōtoku, Japan

  • Cancer Research Cent 4

    Tbilisi, Georgia

  • Centre Antoine Lacassagne

    Nice, France

  • Centre Eugène Marquis

    Rennes, France

  • Centre Guillaume Le Conquerant

    Le Havre, France

  • Centre Henri Becquerel CLCC

    Rouen, France

  • Centre Hospitalier Universitaire Vaudois Lausanne

    Lausanne, Switzerland

  • Centre Hospitalier de l'Ardenne (CHA)

    Libramont, Belgium

  • Centre Jean Perrin CLCC

    Clermont-Ferrand, France

  • Centre Leon Berard

    Lyon, France

  • Centre Oscar Lambret

    Lille, France

  • Centre hospitalier Libourne

    Libourne, France

  • Centre hospitalier Universitaire de Bordeaux

    Bordeaux, France

  • Centro Clinico Academico

    Braga, Portugal

  • Centro Gaúcho Integrado, Rua Costa

    Porto Alegre, Brazil

  • Centro Hospitalar Universitario São João

    Porto, Portugal

  • Centro Hospitalar Universitário Lisboa Norte

    Lisbon, Portugal

  • Centro Hospitalar Universitário do Algarve - Hospital de Faro (PRT)

    Faro, Portugal

  • Centro Hospitalar de Vila Nova de Gaia/Espinho

    Porto, Portugal

  • Centro di Riferimento Oncologico

    Aviano, Italy

  • Centrum Onkologii- Instytut im. Marii Sklodowskiej-Curie Oddzial w Gliwicach

    Gliwice, Poland

  • Chang Gung Medical Foundatoin Linkou Chang Gung Memorial Hospital

    Taoyuan, Taiwan

  • Chang-Gung Memorial Hospital-Kaohsiung

    Kaohsiung City, Taiwan

  • Charing Cross Hospital

    London, United Kingdom

  • Charité - Universitätsmedizin Berlin Campus Virchow

    Berlin, Germany

  • China Medical University Hospital

    Taichung, Taiwan

  • Clatterbridge Cancer Centre NHS Foundation Trust

    Metropolitan Borough of Wirral, United Kingdom

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Universidad de Navarra

    Madrid, Spain

  • Clinica Universidad de Navarra

    Pamplona, Spain

  • Clinica Universitaria Reina Fabiola

    Córdoba, Argentina

  • Clinica Viedma

    Viedma, Argentina

  • Clinique Victor Hugo

    Le Mans, France

  • Cliniques universitaires Saint-Luc

    Brussels, Belgium

  • Columbus Regional Research Institute

    Columbus, Georgia, 31904, United States

  • Comprehensive Cancer Center of Nevada (Southern Hills) (USA)

    Las Vegas, Nevada, 89148, United States

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89169, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Department of radiation oncology, University Hospital Essen

    Essen, Germany

  • EuroCityClinic

    Saint Petersburg, Russia

  • Evex Hospitals Oncology Center

    Kutaisi, Georgia

  • FGBU N.N.Blokhin Russian Cancer Research Center

    Moscow, Russia

  • FSBI National Med Research Cancer Center N.N. Petrov

    Saint Petersburg, Russia

  • Fakultni Nemocnice Ostrava

    Ostrava-Poruba, Czechia

  • Fondazione Policlinico Universitario Agostino Gemelli

    Rome, Italy

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Fudan University Shanghai Cancer Center

    Shanghai, China

  • Fujian Cancer Hospital

    Fuzhou, China

  • Fundacin Oncolgico de Galicia Jos Antonio Quiroga y Pieyro

    A Coruña, Spain

  • Fundacio Althaia

    Manresa, Spain

  • Fundacion Centro Oncologico de Galicia (COG) "Jose Antonio Quiroga y Pineyro"

    A Coruña, Galicia, Spain

  • Fundacion Investigacion Hospital General Universitario de Valencia FiHgU (ESP)

    Valencia, Spain

  • Fundação Pio XII- Hospital de Cancer de Barretos, Rua Antenor Duarte Vilela

    Barretos, Brazil

  • GZA Sint-Augustinus

    Wilrijk, Belgium

  • Gettysburg Cancer Center

    Gettysburg, Pennsylvania, 17325, United States

  • Grand Hopital de Charleroi

    Charleroi, Belgium

  • Harbin Medical University Cancer Hospital

    Harbin, China

  • Henan Cancer Hospital

    Zhengzhou, China

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Hokkaido University Hospital

    Kita-ku, Japan

  • Hopital Maisonneuve-Rosemont

    Montreal, Canada

  • Hopital de Jolimont, Rue Ferrer

    La Louvière, Belgium

  • Hopitaux Universitaires de Geneve

    Geneva, Switzerland

  • Hospital 12 de Octubre

    Madrid, Spain

  • Hospital Aleman

    Buenos Aires, Argentina

  • Hospital Civil (Hospital Regional Universitario)

    Málaga, Spain

  • Hospital Clinic Barcelona

    Barcelona, Spain

  • Hospital Clinico San Carlos

    Madrid, Spain

  • Hospital Na Bulovce

    Prague, Czechia

  • Hospital Pedro Hispano

    Porto, Portugal

  • Hospital Ramon y Cajal

    Madrid, Spain

  • Hospital Reina Sofía

    Córdoba, Spain

  • Hospital Santa Rita Centro de Pesquisa Clínica Novos Tratamentos Em Câncer

    Porto Alegre, Brazil

  • Hospital Santa Rita, Centro de Pesquisa Clínica Novos Tratamentos Em Câncer

    Porto Alegre, Brazil

  • Hospital Universitari Vall d'Hebron

    Barcelona, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, Spain

  • Hospital Universitario Insular de Gran Canaria

    Las Palmas de Gran Canaria, Spain

  • Hospital Universitario La Fe

    Valencia, Spain

  • Hospital Universitario La Paz

    Madrid, Spain

  • Hospital Universitario Marqués de Valdecilla. Santander

    Santander, Spain

  • Hospital de Base de Sao Jose do Rio Preto, Av. Brigadeiro Faria Lima

    São José do Rio Preto, Brazil

  • Hospital de Braga

    Braga, Portugal

  • Hospital de Caridade de Ijui, Avenida David Jose Martins

    Ijuí, Brazil

  • Hospital del Mar

    Barcelona, Spain

  • Hunan Cancer Hospital

    Changsha, China

  • Hyogo Cancer Center

    Hyōgo, Japan

  • Hôpital Nord Franche Comté

    Montbéliard, France

  • Hôpital du Scorff

    Lorient, France

  • IACT Health, John B. Amos Cancer Center

    Columbus, Georgia, 31904, United States

  • ICANS

    Strasbourg, France

  • IHO Corporation/Utah Cancer Specialists

    Salt Lake City, Utah, 84106, United States

  • IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)

    Meldola, Italy

  • IRCCS AOU San Martino

    Genova, Italy

  • IRCCS-Istituto Europeodi Oncologia The European Institute of Oncology IEO

    Milan, Italy

  • IVO

    Valencia, Spain

  • Inselspital, Bern University Hospital, Universitätsklinik für Radio-Onkologie

    Bern, Switzerland

  • Institut Català d'Oncologia

    Girona, Spain

  • Institut Català d'Oncologia Badalona

    Barcelona, Spain

  • Institut Català d'Oncologia, Hospital Duran

    Barcelona, Spain

  • Institut Claudius Regaud - IUCT-O

    Toulouse, France

  • Institut Curie

    Paris, France

  • Institut Gustave Roussy - Service de radiotherapie

    Villejuif, France

  • Institut Regional du Cancer de Montpellier

    Montpellier, France

  • Institut Sainte Catherine

    Avignon, France

  • Institut Universitari Dexeus-Quiron (ESP)

    Barcelona, Spain

  • Institut de Cancérologie de l Ouest (ICO)

    Angers, France

  • Institut de Cancérologie de l'Ouest - Site Saint Herblain

    Saint-Herblain, France

  • Institute of Clinical Oncology

    Tbilisi, Georgia

  • Instituto Medico Especialazado Alexander Fleming

    Buenos Aires, Argentina

  • Instituto Portugues de Oncologia Porto Francisco Gentil, E.P.E

    Porto, Portugal

  • Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE

    Coimbra, Portugal

  • Instituto de Oncologia de Rosario

    Santa Fe, Argentina

  • Instituto do Cancer do Estado de Sao Paulo (ICESP)

    São Paulo, Brazil

  • Inventa Center for Cancer Research At Fort Wayne Medical Oncology and Hematology

    Fort Wayne, Indiana, 46804, United States

  • Istituto Nazionale Tumori (INT) IRCCS Fondazione "G. Pascale"

    Naples, Italy

  • Istituto Nazionale dei Tumori

    Milan, Italy

  • Istituto Oncologico Veneto Irccs

    Padua, Italy

  • Istituto di Candiolo IRCCS

    Candiolo, Italy

  • JSC "Evex Hospitals"

    Tbilisi, Georgia

  • Jilin Cancer Hospital

    Changchun, China

  • KOC KNTB a.s. Zlín

    Zlín, Czechia

  • Kaohsiung Medical University Memorial Hospital

    Kaohsiung City, Taiwan

  • Karmanos Cancer institute

    Detroit, Michigan, 48302, United States

  • Kiev City Clinical Oncology Centre

    Kiev, Ukraine

  • Klinische Abteilung fur Allgemeine HNO Universitatsklinik fur Hals-, Nasen- und Ohrenheilkunde

    Graz, Austria

  • Kobe University Hospital

    Kobe, Japan

  • KonKuk University Medical Center

    Seoul, South Korea

  • Korea University Anam Hospital

    Seoul, South Korea

  • Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I.Kryzhanovsky

    Krasnoyarsk, Russia

  • Kursk Regional Clinical Oncology Dispensary

    Kursk, Russia

  • LEPL First University Clinic of Tbilisi State Medical University

    Tbilisi, Georgia

  • LHopital prive du Confluent Nantes

    Nantes, France

  • Landeskrankenhaus Salzburg

    Salzburg, Austria

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Liaoning Cancer Hospital & institute

    Shenyang, China

  • Liga Norte Riograndense Contra o Câncer, Avenida Miguel Castro

    Natal, Brazil

  • Lin Yi Cancer Hospital

    Shandong, China

  • Lombardi Comprehensive Cancer Center, Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • London Regional Cancer Program, London Health Sciences Centre

    London, Canada

  • MD Anderson

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114-2696, United States

  • Medical University of South Carolina- Hollings Cancer Center

    Charleston, South Carolina, 29425, United States

  • Medical University of Vienna, Department of Medicine I, Division of Oncology

    Vienna, Austria

  • Medical center ASKLEPION LLC

    Khodosovka, Ukraine

  • Medical center of Yuriy Spizhenko, Soborna Vulytsia

    Kyiv, Ukraine

  • MidAmerica Cancer Care

    Kansas City, Missouri, 64114, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Mount Vernon Cancer Centre

    Northwood, United Kingdom

  • NHS Greater Glasgow and Clyde

    Glasgow, United Kingdom

  • NYU Grossman School of Medicine

    New York, New York, 10016, United States

  • NYU Langone Hospital-Long Island Oncology

    Mineola, New York, 11501, United States

  • NZOZ Provita Prolife Centrum Medyczne

    Lodz, Poland

  • National Cancer Center

    Goyang-si, South Korea

  • National Cancer Center Hematologic Oncology

    Goyang-si, South Korea

  • National Cancer Center Hospital

    Chuo-ku Tokyo, Japan

  • National Cancer Center Hospital East

    Chiba, Japan

  • National Cancer Institute

    Rio de Janeiro, Brazil

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Japan

  • National Taiwan University Hospital

    Taipei, Taiwan

  • New Hospitals

    Tbilisi, Georgia

  • Norton Cancer Institute, Louisville, Kentucky, Brownsboro Hospital Campus

    Louisville, Kentucky, 40241, United States

  • Nottingham University Hospitals NHS Trust

    Nottingham, United Kingdom

  • Ohio State University

    Columbus, Ohio, 43210, United States

  • Okayama University Hospital

    Kita-ku, Japan

  • Orszagos Onkologiai Intezet Sugarterapias Osztaly

    Budapest, Hungary

  • Osaka International Cancer Institute

    Osaka, Japan

  • Ospedale "Vito Fazzi" Lecce

    Lecce, Italy

  • Oswaldo Cruz German Hospital

    São Paulo, Brazil

  • Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intazet

    Pécs, Hungary

  • Peking Union Medical College Hospital

    Beijing, China

  • Peter MacCallum Cancer Centre

    Melbourne, Australia

  • Petz Aladár Megyei Kórház Onkoradiológiai Osztály

    Győr, Hungary

  • Policlinico di Modena

    Modena, Italy

  • Princess Alexandra Hospital, Cancer Trials Unit

    Woolloongabba, Australia

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Pusan National University Hospital

    Busan, South Korea

  • Pusan National University Yangsan Hospital, Oncol & Hematology

    Yangsan, South Korea

  • Rabin Medical Center

    Petach Tiqva, Israel

  • Rambam Healthcare Campus

    Haifa, Israel

  • Regents of the University of California

    San Francisco, California, 94158, United States

  • Republican Clinical Oncological Dispensary of Bashkortostan

    Ufa, Russia

  • Research Fund of the Hadassah Medical Organization

    Jerusalem, Israel

  • Royal Marsden NHS Foundation Trust

    Chelsea, United Kingdom

  • Royal Surrey County Hospital

    Guildford, United Kingdom

  • SP ZOZ MSWiA z W-M CO w Olsztynie

    Olsztyn, Poland

  • Saint- Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology)

    Saint Petersburg, Russia

  • Saitama Medical University International Medical Center

    Hidaka, Japan

  • Seoul National University Boramae Medical Center

    Seoul, South Korea

  • Service d'Oncologie Médicale, CHU Timone

    Marseille, France

  • Shanghai Ninth People's Hospital

    Shanghai, China

  • Shantou University Cancer Hospital

    Shantou, China

  • Sheba Medical Center

    Ramat Gan, Israel

  • Shizuoka Cancer Center

    Nagaizumi-cho, Japan

  • Simon Khechinashvili University Clinic

    Tbilisi, Georgia

  • St Vincents Hospital

    Darlinghurst, Australia

  • St Vincents Hospital Melbourne

    Fitzroy, Australia

  • State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan"

    Kazan', Russia

  • State Budgetary Healthcare Institution Republican Clinical Oncology Dispensary (RUS)

    Ufa, Russia

  • State Budgetary Institution of Healthcare of Yaroslavl region Clinical oncology hospital

    Yaroslavl, Russia

  • Strahlenklinik des Uni-Klinikums

    Erlangen, Germany

  • Sunnybrook Research Institute

    Toronto, Canada

  • Szegedi Tudományegyetem ÁOK Onkoterápiás Klinika

    Szeged, Hungary

  • Szpitale Pomorskie Sp. z o.o.

    Gdynia, Poland

  • Taichung Veterans General Hospital

    Taichung, Taiwan

  • Taipei Veterans General Hospital (VGHTP)

    Taipei, Taiwan

  • The 2nd Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, China

  • The 5th Affiliated Hospital of Sun yet-sen university

    Guangdong, China

  • The Christie NHS Foundation Trust

    Manchester, United Kingdom

  • The Oncology Institute of Hope & Innovation

    Whittier, California, 90603, United States

  • The Public Hospital L'Institut de Cancerologie de Lorraine

    Vandœuvre-lès-Nancy, France

  • The Royal Marsden NHS Foundation Trust - Sutton

    Sutton, United Kingdom

  • The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC)

    Birmingham, Alabama, 35233, United States

  • Theagenio Anticancer Hospital

    Thessaloniki, Greece

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, China

  • Tokai University Hospital

    Kanagawa, Japan

  • Tokyo Medical University Hospital

    Tokyo, Japan

  • Tongji Hospital/Tongji Medical College, Huazhong University of Science

    Wuhan, China

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCSF

    San Francisco, California, 94158, United States

  • UZ Leuven, Radiotherapy & Oncology

    Leuven, Belgium

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, China

  • Universitaetsklinikum Jena - Klinik fuer Hals - Nasen und Ohrenheilkunde HNO

    Jena, Germany

  • Universitaetsklinikum Regensburg

    Regensburg, Germany

  • Universitaetsmedizin Mannheim UMM, Klinik fuer Hals-Nasen-Ohrenheilkunde Kopf- und Halschirurgie

    Mannheim, Germany

  • Universitaetsmedizin Rostock

    Rostock, Germany

  • Universitair Ziekenhuis Antwerpen

    Edegem, Belgium

  • Universitair Ziekenhuis Gent UZ Gent

    Ghent, Belgium

  • Universitatsklinikum Leipzig AoR, Klinik für Strahlentherapie

    Leipzig, Germany

  • University Hospital Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University Hospital Kyoto Prefectural University of Medicine

    Kamigyō-ku, Japan

  • University Hospital Southampton NHS Foundation Trust

    Southampton, United Kingdom

  • University Hospital hradec Kralové

    Hradec Králové, Czechia

  • University Medical Center Schleswig-Holstein, Campus Kiel

    Kiel, Germany

  • University South Hospital

    Ann Arbor, Michigan, 48109-9001, United States

  • University of Arizona Cancer Center

    Tucson, Arizona, 85724, United States

  • University of Cincinnati Medical Center

    Cincinnati, Ohio, 45267, United States

  • University of Colorado at Denver and Health Sciences Center

    Aurora, Colorado, 80045, United States

  • University of Missouri - Ellis Fischel Cancer Center

    Columbia, Missouri, 65212, United States

  • University of Oklahoma Health Sciences Center- Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Virginia Medical Center

    Charlottesville, Virginia, 22908, United States

  • Universitätsklinik für Innere Medizin III der PMU

    Salzburg, Austria

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, Germany

  • Univesitätsklinikum Essen (AöR) Klinikum und Poliklinik für Strahlentherapie

    Essen, Germany

  • Uniwersyteckie Centrum Kliniczne - Klinika Onkologii i Radioterapii

    Gdansk, Poland

  • Uzsoki Utcai Korhaz Onkologiai Osztaly

    Budapest, Hungary

  • Wake Forest University School of Medicine

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • West China Hospital of Sichuan University

    Chengdu, China

  • Wollongong Hospital

    Wollongong, Australia

  • Xiangya Hospital Central South University

    Changsha, China

  • Yale Cancer Center

    New Haven, Connecticut, 06519, United States

  • Zhejiang Province Cancer Hospital

    Hangzhou, China

Conditions

Explore the condition pages connected to this study.