New drug tested to stop aggressive head & neck cancer from coming back

NCT ID NCT05386550

Summary

This study tested whether adding an experimental drug called xevinapant to standard radiotherapy could better prevent cancer from returning in people with high-risk head and neck cancer who had surgery. It focused on patients who could not safely take the usual high-dose chemotherapy drug, cisplatin. The main goal was to see if the combination helped patients live longer without their cancer coming back.

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Contacts and locations

Locations

  • A.O.U. Policlinico di Modena - U.O. Oncologia

    Modena, Italy

  • Aichi Cancer Center Hospital - Dept of Head and Neck Surgery

    Nagoya, Japan

  • All India Institute of Medical Sciences

    New Delhi, India

  • Amsterdam UMC, Locatie VUMC - Dept of Medical Oncology

    Amsterdam, Netherlands

  • Anhui Provincial Cancer Hospital

    Hefei, China

  • Antwerp University Hospital (UZA Parent)

    Edegem, Belgium

  • Azienda Ospedaliera Universitaria Careggi - S.O.D. di Oncologia Medica

    Florence, Italy

  • Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza - U.O.C. di Oncologia B

    Roma, Italy

  • Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli" - Dipartimento Oncologia

    Naples, Italy

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili) - Oncologia Medica

    Brescia, Italy

  • BP A Beneficencia Portuguesa da Sao Paulo

    São Paulo, Brazil

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Beijing Cancer Hospital

    Beijing, China

  • CEMAIC- Centro Medico Privado

    Las Margaritas, Argentina

  • CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABC

    Santo André, Brazil

  • CEPON - Centro de Pesquisas Oncológicas de Santa Catarina - Pesquisa Clínica

    Florianópolis, Brazil

  • CHI Toulon La Seyne - Hôpital Sainte Musse - Service d'Onco-Hematologie

    Toulon, France

  • CHU Bordeaux - Service d'Oncologie Médicale

    Bordeaux, France

  • CHU Brest - Hôpital Morvan - Service d'Oncologie Médicale

    Brest, France

  • CHU Poitiers - Hôpital la Milétrie - service d'oncologie médicale

    Poitiers, France

  • CHU Tours - Hôpital Bretonneau - Service d'Oncologie Médicale

    Tours, France

  • CHUV, Lausanne University Hospital

    Lausanne, Switzerland

  • CRIO - Centro Regional Integrado de Oncologia

    Fortaleza, Brazil

  • Cancer Institute Hospital of JFCR - Dept of Medical Oncology

    Kōtoku, Japan

  • Cancer Research Center Ltd.

    Tbilisi, Georgia

  • Centre Antoine Lacassagne - Service d'Hématologie Oncologie

    Nice, France

  • Centre Azureen Cancerologie - Service De Radiotherapie

    Mougins, France

  • Centre Francois Baclesse - Service d'Oncologie Medicale

    Caen, France

  • Centre Georges François Leclerc - Oncologie Médicale

    Dijon, France

  • Centre Henri Becquerel - Service de radiothérapie

    Rouen, France

  • Centre Hospitalier Privé Saint-Gregoire (Rennes) - Cancerologie

    Saint-Grégoire, France

  • Centre Hospitalier de Bretagne Sud

    Lorient, France

  • Centre Hospitalier de l'Universite de Montreal.

    Montreal, Canada

  • Centre Hospitalier de la Croix Rousse - Service ORL et chirurgie cervico-faciale

    Lyon, France

  • Centre Oscar Lambret - service de cancerologie gynecologique

    Lille, France

  • Centro Oncologico Riojano Integral (CORI)

    La Rioja, Argentina

  • Centro de Atención e Investigación Clínica en Oncología

    Mérida, Mexico

  • Centrul medical Focus

    Bucharest, Romania

  • Chaim Sheba Medical Center - pt

    Ramat Gan, Israel

  • Chang Gung Memorial Hospital,Linkou

    Taoyuan District, Taiwan

  • Changhua Christian Medical Foundation Changhua Christian Hospital

    Changhua, Taiwan

  • Chi Mei Hospital, Liouying

    Tainan, Taiwan

  • China Medical University Hospital

    Taichung, Taiwan

  • Chongqing University Cancer Hospital

    Chongqing, China

  • Chonnam National University Hwasun Hospital

    Hwasun-gun, South Korea

  • Clatterbridge Cancer Centre

    Metropolitan Borough of Wirral, United Kingdom

  • Clinica Universidad de Navarra (MAD) - Oncology Service

    Madrid, Spain

  • Clinica Viedma S.A.

    Viedma, Argentina

  • Clinique Victor Hugo - Centre Jean Bernard - Service d'Oncologie Médicale

    Le Mans, France

  • Cliniques Universitaires Saint-Luc - STL

    Brussels, Belgium

  • Complejo Hospitalario Universitario A Coruña - CHUAC-Hospital Teresa Herrera

    A Coruña, Spain

  • Complejo Hospitalario Universitario A Coruña - Servicio de Oncologia

    A Coruña, Spain

  • Complejo Hospitalario Universitario Insular Materno-Infantil - Servicio de Oncologia

    Las Palmas de Gran Canaria, Spain

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Fakultni nemocnice Bulovka - Dept of Radiodiagnosticka klinika

    Prague, Czechia

  • Fakultni nemocnice Kralovske Vinohrady - Dept of Radioterapeuticka a onkologicka klinika

    Prague, Czechia

  • Fakultni nemocnice Olomouc - Dept of Onkologicka klinika

    Olomouc, Czechia

  • Fondazione IRCCS Istituto Nazionale dei Tumori - S.S. Tumori della Testa e del Collo

    Milan, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Radioterapia 1

    Roma, Italy

  • Fondazione del Piemonte per l'Oncologia IRCC Candiolo - Div. di Oncologia Medica ed Ematologia

    Candiolo, Italy

  • Fudan University Shanghai Cancer Center

    Shanghai, China

  • Fujian Cancer Hospital

    Fuzhou, China

  • Fundacion Scherbovsky

    Mendoza, Argentina

  • General Hospital of Athens of Chest Diseases "SOTIRIA" - Sotiria Thoracic Diseases Hospital of Athens

    Athens, Greece

  • Grupo Oncoclínicas

    Rio de Janeiro, Brazil

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, China

  • HGB - Hospital Giovanni Battista - Mãe de Deus Center

    Porto Alegre, Brazil

  • Hadassah University Hospital - Ein Kerem

    Jerusalem, Israel

  • Henan Cancer Hospital

    Zhengzhou, China

  • High Technology Hospital Medcenter LLC

    Batumi, Georgia

  • High Technology Medical Center, University Clinic

    Tbilisi, Georgia

  • Hiroshima University Hospital - Dept of Otorhinolaryngology/ Head and Neck Surgery

    Hiroshima, Japan

  • Hokkaido University Hospital - Dept of Otorhinolaryngology

    Sapporo, Japan

  • Hopital Prive Drome Ardeche - Service D Oncologie

    Guilherand-Granges, France

  • Hopital Tenon - service radiologie et imagerie medicale

    Paris, France

  • Hospital Civil Fray Antonio Alcalde - O.P.D. Hospital Civil de Guadalajara

    Guadalajara, Mexico

  • Hospital Clinic de Barcelona - Medical Oncology

    Barcelona, Spain

  • Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer

    Curitiba, Brazil

  • Hospital Regional Universitario de Malaga - Oncology Dept

    Málaga, Spain

  • Hospital Santa Izabel - Santa Casa de Misericórdia da Bahia

    Salvador, Brazil

  • Hospital Universitari Vall d'Hebron - Oncology Dept.

    Barcelona, Spain

  • Hospital Universitario Fundacion Jimenez Diaz - Oncology

    Madrid, Spain

  • Hospital Universitario La Paz - Oncology Department

    Madrid, Spain

  • Hospital Universitario Lucus Augusti - Oncology

    Lugo, Spain

  • Hospital Universitario Virgen del Rocio - Oncology Service

    Seville, Spain

  • Hospital de Braga - Serviço de Oncologia Medica

    Braga, Portugal

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, Brazil

  • Hospital de Câncer de Barretos - Fundação Pio XII - Hospital de Amor

    Barretos, Brazil

  • Hospital del Mar - Servicio de Oncologia

    Barcelona, Spain

  • Hospital of Bengbu Medical College

    Bengbu, China

  • Hunan Cancer Hospital

    Changsha, China

  • Hyogo Cancer Center - Dept of Head and Neck Surgery

    Akashi-shi, Japan

  • Hôpital de la Timone - Oncologie Médicale Hématologie & Soins Palliatifs

    Marseille, France

  • ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira

    São Paulo, Brazil

  • ICO - Site Paul Papin - service d'oncologie medicale

    Angers, France

  • ICO - Site René Gauducheau - Service d'Oncologie medicale

    Saint-Herblain, France

  • ICO Badalona - Hospital Universitari Germans Trias i Pujol - Servicio de Oncologia Medica

    Barcelona, Spain

  • ICO l'Hospitalet - Hospital Duran i Reynals - Servicio de Oncologia

    Barcelona, Spain

  • IEO Istituto Europeo di Oncologia - Divisione Oncologia Medica

    Milan, Italy

  • INCA - Instituto Nacional de Câncer

    Rio de Janeiro, Brazil

  • IOV - Istituto Oncologico Veneto IRCCS - Oncologia Medica 2

    Padua, Italy

  • IRCCS Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori "Dino Amadori" - IRST - U. Operativa di Immunoterapia e Terapia Cellulare

    Meldola, Italy

  • Institut Claudius Regaud - service de Radiothérapie

    Toulouse, France

  • Institut Curie - site de Paris - Service d'Oncologie Médicale

    Paris, France

  • Institut Gustave Roussy - Oncologie Médicale

    Villejuif, France

  • Institut Jules Bordet - Medical Oncology

    Anderlecht, Belgium

  • Institut Régional du Cancer de Montpellier - Service de Professeur Senesse

    Montpellier, France

  • Institut de Cancérologie de Strasbourg Europe - ICANS - Service d'oncologie médicale

    Strasbourg, France

  • Instituto Português de Oncologia do Porto Francisco Gentil, EPE

    Porto, Portugal

  • Instituto de Cancer de Londrina

    Londrina, Brazil

  • Instituto de Oncologia Angel Roffo

    Ciudad Autonoma Buenos Aires, Argentina

  • Interbalkan Hospital of Thessaloniki

    Thessaloniki, Greece

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre

    Porto Alegre, Brazil

  • Istituto Clinico Humanitas - U.O. di Oncologia Medica ed Ematologia

    Rozzano, Italy

  • Istituto Nazionale Tumori Fondazione G. Pascale - Oncologia Medica A

    Naples, Italy

  • Istituto Oncologico della Svizzera Italiana (IOSI)- Ente Ospedaliero Cantonale (EOC) - Ospedale S.Giovanni

    Bellinzona, Switzerland

  • JSC EVEX Hospitals

    Kutaisi, Georgia

  • Jiangxi Cancer Hospital

    Nanchang, China

  • Kagawa University Hospital - Dept of Oncology

    Kita-gun, Japan

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, Taiwan

  • Kindai University Hospital - Dept of Oncology

    Osakasayama-shi, Japan

  • Kobe University Hospital - Dept of Oncology/Hematology

    Kobe, Japan

  • Konkuk University Medical Center

    Seoul, South Korea

  • Krankenhaus der barmherzigen Schwestern Linz - Abteilung für HNO

    Linz, Austria

  • LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie

    Salzburg, Austria

  • LLC Todua Clinic

    Tbilisi, Georgia

  • Liga Norte-Rio-Grandense Contra o Câncer

    Natal, Brazil

  • Montefiore Medical Center Radiology

    The Bronx, New York, 10461, United States

  • Mount Vernon Cancer Centre

    Northwood, United Kingdom

  • Musgrove Park Hospital - PARENT

    Somerset, United Kingdom

  • NHO Hokkaido Cancer Center - Dept of Oral Oncology Surgery

    Sapporo, Japan

  • NHO Kyushu Cancer Center - Dept of Head and Neck Surgery

    Fukuoka, Japan

  • NHO Shikoku Cancer Center - Dept of Head and Neck Surgery

    Matsuyama, Japan

  • Nagoya University Hospital - Dept of Otorhinolaryngology

    Nagoya, Japan

  • Nanjing Drum Tower Hospital

    Nanjing, China

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie, Państwowy Instytut Badawczy - Zakład Medycyny Nuklearnej i Endokrynologii Onkolo

    Gliwice, Poland

  • National Cancer Center Hospital - Dept of Gastroenterology

    Chūōku, Japan

  • National Cancer Center Hospital East - Dept of Head and Neck Medical Oncology

    Kashiwa-shi, Japan

  • National Cancer Institute Nagpur

    Nagpur, India

  • National Cheng Kung University Hospital

    Tainan, Taiwan

  • National Taiwan University Hospital

    Taipei, Taiwan

  • New Hospitals

    Tbilisi, Georgia

  • Northern Jiangsu People's Hospital

    Yangzhou, China

  • Okayama University Hospital - Dept of Otorhinolaryngology

    Okayama, Japan

  • Oncosite - Centro de Pesquisa Clinica e Oncologia

    Ijuí, Brazil

  • Osaka International Cancer Institute - Dept of Head and Neck Surgery

    Osaka, Japan

  • Ospedale Oncologico Armando Businco - Divisione di Oncologia Medica II

    Cagliari, Italy

  • Ospedale San Raffaele - U.O. di Oncologia Medica

    Milan, Italy

  • Perlmutter Cancer Center at NYU Langone Hospital ae Long Island

    New York, New York, 10016, United States

  • Prisma Health Cancer Institute, ITOR, CRU

    Greenville, South Carolina, 29605, United States

  • Pusan National University Yangsan Hospital

    Yangsan, South Korea

  • Rambam Health Care Campus

    Haifa, Israel

  • Regional Cancer Centre

    Thiruvananthapuram, India

  • Royal Marsden Hospital-London - Dept of Haematology/Oncology Research

    London, United Kingdom

  • S.C Centrul de Oncologie Sf. Nectarie S.R.L - parent

    Craiova, Romania

  • S.C Medisprof S.R.L - parent

    Cluj-Napoca, Romania

  • S.C Oncocenter Oncologie Clinica S.R.L - parent

    Timișoara, Romania

  • S.C Radiotherapy Center Cluj S.R.L - Parent

    ComunaFloresti, Romania

  • Saitama Cancer Center - Dept of Head and Neck Surgery

    Kitaadachi-gun, Japan

  • Saitama Medical University International Medical Center - Dept of Otorhinolaryngology/ Head and Neck Surgery

    Hidaka-shi, Japan

  • Seoul National University Bundang Hospital

    Seongnam, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, South Korea

  • Shandong Cancer Hospital

    Jinan, China

  • Shanghai General Hospital

    Shanghai, China

  • Shengjing Hospital of China Medical University

    Shenyang, China

  • Sichuan Cancer Hospital

    Chengdu, China

  • Sir Run Shaw Hospital, Zhejiang University, School of Medicine

    Hangzhou, China

  • Soroka University Medical Center

    Beersheba, Israel

  • St James's University Hospital - Dept of Oncology

    Leeds, United Kingdom

  • Sun Yat-sen University Cancer Center

    Guangzhou, China

  • Taipei Veterans General Hospital

    Taipei, Taiwan

  • Tata Medical Centre

    Kolkata, India

  • The Catholic University of Korea, St. Vincent's Hospital

    Suwon, South Korea

  • The Christie Hospital - Dept of Oncology

    Manchester, United Kingdom

  • The First Hospital of Jilin University

    Changchun, China

  • The Royal Marsden NHS Foundation Trust

    Sutton, United Kingdom

  • The Second Affiliated Hospital of Xi'an Jiaotong University(Xibei Hospital)

    Xi'an, China

  • The University of Arizona Cancer Center

    Tucson, Arizona, 85719, United States

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, China

  • Tohoku University Hospital - Dept of Otorhinolaryngology/Head and Neck Surgery

    Sendai, Japan

  • Torbay Hospital - PARENT

    Torquay, United Kingdom

  • UC Health

    Aurora, Colorado, 80045, United States

  • UMC Utrecht - Dept Medical Oncology

    Utrecht, Netherlands

  • Union Hospital, Tongji Medical College of Huazhong University of Science & Technology

    Wuhan, China

  • Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez

    Monterrey, Mexico

  • Universitaetsklinikum Giessen und Marburg GmbH Standort Giessen - Hals-, Nasen- und Ohrenklinik

    Giessen, Germany

  • Universitaetsklinikum Jena - HNO_Klinik

    Jena, Germany

  • Universitaetsklinikum Leipzig - Klinik fuer Strahlentherapie und Radioonkologie

    Leipzig, Germany

  • Universitaetsklinikum Schleswig-Holstein - Campus Kiel - Klinik für diagnostische Radiologie

    Kiel, Germany

  • Universitaetsmedizin Goettingen - Georg-August-Universität

    Göttingen, Germany

  • Universitaetsmedizin Rostock - Klinik und Poliklinik für Strahlentherapie

    Rostock, Germany

  • Universitaetsspital Basel - Klinik fuer Strahlentherapie und Radioonkologie

    Basel, Switzerland

  • Universitaetsspital Zuerich - Parent

    Zurich, Switzerland

  • Universitair Medisch Centrum Groningen - Cancer Center

    Groningen, Netherlands

  • Universitatsklinikum Graz

    Graz, Austria

  • University General Hospital "Attikon"

    Athens, Greece

  • University of Alabama at Birmingham - Dept of Radiation Oncology

    Birmingham, Alabama, 35249, United States

  • University of Cincinnati Cancer Institute

    Cincinnati, Ohio, 45219, United States

  • University of Pittsburgh Medical Center Health System - UPMC Department of Dermatology

    Pittsburgh, Pennsylvania, 15219, United States

  • Vitaz

    Sint-Niklaas, Belgium

  • Vivantes Klinikum Neukoelln - Parent

    Berlin, Germany

  • West China Hospital, Sichuan University

    Chengdu, China

  • Xiangya Hospital, Central South University

    Changsha, China

  • Yokohama City University Hospital - Dept of Otorhinolaryngology

    Yokohama, Japan

  • Zhejiang Cancer Hospital

    Hangzhou, China

Conditions

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