Major cancer trial tests new combo to stop head & neck tumors

NCT ID NCT03040999

Summary

This large, completed Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation treatment works better than chemoradiation alone for people with locally advanced head and neck cancer. The study enrolled 804 patients to see if the combination could better prevent the cancer from coming back or spreading (event-free survival) and improve overall survival. It also carefully tracked side effects and quality of life measures like swallowing, speech, and pain.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 2. LF UK a FN Motol ( Site 0704)

    Prague, 150 06, Czechia

  • Allgemeines Krankenhaus der Stadt Wien ( Site 0602)

    Vienna/Wien, 1090, Austria

  • Ankara Sehir Hastanesi ( Site 1108)

    Ankara, 06800, Turkey (Türkiye)

  • Azienda Ospedaliera San Paolo ( Site 0952)

    Milan, 20142, Italy

  • Azienda Ospedaliero Universitaria Careggi ( Site 0955)

    Florence, 50134, Italy

  • Azienda Ospedaliero Universitaria di Modena Policlinico ( Site 0954)

    Modena, MO, 41124, Italy

  • Barbara Ann Karmanos Cancer Institute ( Site 0272)

    Detroit, Michigan, 48201, United States

  • Basken Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 1103)

    Adana, 01250, Turkey (Türkiye)

  • Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1005)

    Bielsko-Biala, 43-300, Poland

  • Blacktown Hospital Western Sydney Local Health District ( Site 0304)

    Blacktown, New South Wales, 2148, Australia

  • C.H.U. Sart Tilman-Service d'Oncologie Medicale ( Site 0654)

    Liège, 4000, Belgium

  • CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0057)

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Capital & Coast District Health Board - Wellington Hospital ( Site 0400)

    Wellington, Newtown, 6021, New Zealand

  • Centre Jean Bernard Laboratoire Mahe Meziani ( Site 0760)

    Le Mans, 72000, France

  • Centro Medico Imbanaco de Cali S.A ( Site 0156)

    Cali, Valle del Cauca Department, 760042, Colombia

  • Centro Regional Integrado de Oncologia ( Site 0002)

    Fortaleza, Ceará, 60336-045, Brazil

  • Centro de Investigacion Clinica del Country ( Site 0155)

    Bogotá, 110221, Colombia

  • Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie ( Site 1000)

    Warsaw, 02-781, Poland

  • Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie ( Site 1010)

    Gliwice, 44-101, Poland

  • Chang Gung Medical Foundation - Kaohsiung ( Site 0501)

    Kaohsiung City, 83301, Taiwan

  • Chiba Cancer Center ( Site 0358)

    Chiba, 260-8717, Japan

  • Chungbuk National University Hospital ( Site 0454)

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Chungnam National University Hospital ( Site 0455)

    Daejeon, 35015, South Korea

  • Clinique Francois Chenieux ( Site 0757)

    Limoges, 87039, France

  • Clinique et Maternite Sainte-Elisabeth ( Site 0653)

    Namur, 5000, Belgium

  • Cliniques Universitaires Saint Luc - Bruxelles ( Site 0651)

    Brussels, 1200, Belgium

  • Comprehensive Cancer Centers of Nevada ( Site 8004)

    Las Vegas, Nevada, 89169, United States

  • Cross Cancer Institute ( Site 0064)

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dolnoslaskie Centrum Onkologii. ( Site 1001)

    Wroclaw, Lower Silesian Voivodeship, 53-413, Poland

  • Erasmus University Medical Center ( Site 1354)

    Rotterdam, 3015 GD, Netherlands

  • FN Brno. ( Site 0703)

    Brno, 625 00, Czechia

  • Fakultni Nemocnice Hradec Kralove ( Site 0705)

    Hradec Králové, 500 05, Czechia

  • Fakultni nemocnice Olomouc ( Site 0701)

    Olomouc, 775 20, Czechia

  • Fakultni nemocnice Ostrava ( Site 0702)

    Ostrava, 708 52, Czechia

  • Fondazione IRCCS - Policlinico San Matteo ( Site 0960)

    Pavia, 27100, Italy

  • Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0003)

    Barretos, São Paulo, 14784-400, Brazil

  • Fundacion Valle del Lili ( Site 0150)

    Cali, Valle del Cauca Department, 760032, Colombia

  • H.U. Vall de Hebron ( Site 1052)

    Barcelona, 08035, Spain

  • Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1102)

    Ankara, 06100, Turkey (Türkiye)

  • Hadassah Ein Karem Jerusalem ( Site 0902)

    Jerusalem, 9112001, Israel

  • Hiroshima University Hospital ( Site 0352)

    Hiroshima, 734-8551, Japan

  • Hokkaido University Hospital ( Site 0351)

    Sapporo, Hokkaido, 060-8648, Japan

  • Hospital Clinico San Carlos ( Site 1051)

    Madrid, 28040, Spain

  • Hospital Doce de Octubre ( Site 1054)

    Madrid, 28024, Spain

  • Hospital Duran i Reynals ( Site 1053)

    L'Hospitalet de Llobregat, 08907, Spain

  • Hospital Gral Universitario de Valencia ( Site 1050)

    Valencia, 46014, Spain

  • Hospital Nossa Senhora da Conceicao ( Site 0001)

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hospital Pablo Tobon Uribe ( Site 0151)

    Medellín, Antioquia, 050034, Colombia

  • Hospital Santa Izabel - Santa Casa de Misericordia da Bahia ( Site 0006)

    Salvador, Estado de Bahia, 40050-410, Brazil

  • Hospital Universitario Ramon y Cajal ( Site 1055)

    Madrid, 28034, Spain

  • Hospital Universitario Virgen de la Victoria ( Site 1056)

    Málaga, 29010, Spain

  • Hospital das Clinicas da FMUSP de Ribeirao Preto ( Site 0008)

    Ribeirão Preto, 14048-900, Brazil

  • Hospital de Clinicas de Porto Alegre ( Site 0011)

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Hyogo Cancer Center ( Site 0354)

    Akashi, Hyōgo, 673-8558, Japan

  • Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 1204)

    London, W6 8RF, United Kingdom

  • Indiana University ( Site 0264)

    Indianapolis, Indiana, 46202, United States

  • Inonu Universitesi Tip Fakultesi ( Site 1101)

    Malatya, 44280, Turkey (Türkiye)

  • Institut Claudius Regaud ( Site 0754)

    Toulouse, 31059, France

  • Institut De Cancerologie De Lorraine ( Site 0758)

    Vandœuvre-lès-Nancy, 54500, France

  • Institut Gustave Roussy ( Site 0759)

    Villejuif, 94805, France

  • Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0010)

    Rio de Janeiro, 20230-130, Brazil

  • Instituto do Cancer de Sao Paulo - ICESP ( Site 0004)

    São Paulo, São Paulo, 01246-000, Brazil

  • Ipswich Hospital ( Site 1207)

    Ipswich, Suffolk, IP4 5PD, United Kingdom

  • Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1100)

    Istanbul, 34093, Turkey (Türkiye)

  • Istituto Europeo di Oncologia ( Site 0953)

    Milan, 20141, Italy

  • Istituto Nazionale Tumori ( Site 0950)

    Milan, 20133, Italy

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0951)

    Naples, 80121, Italy

  • Istituto Oncologico Veneto ( Site 0957)

    Padua, 35128, Italy

  • Juravinski Cancer Centre ( Site 0062)

    Hamilton, Ontario, L8V 5C2, Canada

  • Kagawa University Hospital ( Site 0359)

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Klinikum der Universitaet Munchen ( Site 0810)

    München, 81377, Germany

  • Kocaeli Universitesi Tip Fakultesi ( Site 1106)

    Kocaeli, 41380, Turkey (Türkiye)

  • Krankenhaus der Barmherzigen Schwestern Linz ( Site 0603)

    Linz, 4010, Austria

  • Lancashire Teaching Hospitals NHS Foundation Trust ( Site 1208)

    Preston, PR2 9HT, United Kingdom

  • Landeskrankenhaus - Universitatsklinikum Graz ( Site 0601)

    Graz, 8036, Austria

  • Landeskrankenhaus Salzburg ( Site 0600)

    Salzburg, 5020, Austria

  • Liga Norte Riograndense Contra o Cancer ( Site 0005)

    Natal, Rio Grande do Norte, 59075-740, Brazil

  • Linkou Chang Gung Memorial Hospital ( Site 0502)

    Taoyuan District, 333, Taiwan

  • Liverpool Hospital ( Site 0301)

    Liverpool, New South Wales (Australia), 2170, Australia

  • London Health Sciences Centre ( Site 0055)

    London, Ontario, N6A 4L6, Canada

  • MacKay Memorial Hospital ( Site 0505)

    Taipei, 105, Taiwan

  • Mary Bird Perkins Cancer Center at St. Tammany Parish Hospital ( Site 0281)

    Baton Rouge, Louisiana, 70809, United States

  • Mazowiecki Szpital Onkologiczny ( Site 1015)

    Wieliszew, Masovian Voivodeship, 05-135, Poland

  • McGill University Health Centre ( Site 0061)

    Montreal, Quebec, H4A 3J1, Canada

  • Medical Hospital, Tokyo Medical And Dental University ( Site 0356)

    Tokyo, 113-8519, Japan

  • Medical Oncology Associates (Summit Cancer Centers) ( Site 0257)

    Spokane, Washington, 99208, United States

  • Medical Park Izmir Hastanesi ( Site 1109)

    Izmir, 35520, Turkey (Türkiye)

  • Medipol Universite Hastanesi ( Site 1104)

    Istanbul, 34214, Turkey (Türkiye)

  • Medizinische Hochschule Hannover ( Site 0807)

    Hanover, 30325, Germany

  • Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center ( Site 0290)

    Springfield, Missouri, 65804, United States

  • Miyagi Cancer Center ( Site 0353)

    Natori-shi, Miyagi, 981-1293, Japan

  • National Cancer Center Hospital East ( Site 0350)

    Kashiwa, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital ( Site 0503)

    Tainan, 70403, Taiwan

  • National Taiwan University Hospital ( Site 0500)

    Taipei, 10048, Taiwan

  • Nemocnice Na Bulovce ( Site 0700)

    Prague, 180 81, Czechia

  • Noordwest Ziekenhuisgroep NWZ ( Site 1350)

    Alkmaar, 1815 JD, Netherlands

  • Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 1206)

    Norwich, Norfolk, NR4 7UY, United Kingdom

  • Oncology Hematology Care, Inc. ( Site 8003)

    Cincinnati, Ohio, 45242, United States

  • Osaka International Cancer Institute ( Site 0355)

    Osaka, 541-8567, Japan

  • Peter MacCallum Cancer Centre ( Site 0300)

    Melbourne, Victoria, 3000, Australia

  • Princess Alexandra Hospital ( Site 0305)

    Brisbane, Queensland, 4102, Australia

  • Princess Margaret Cancer Centre ( Site 0051)

    Toronto, Ontario, M5G 1X5, Canada

  • Rabin Medical Center ( Site 0904)

    Petah Tikva, 4941492, Israel

  • Rambam MC ( Site 0903)

    Haifa, 3109601, Israel

  • Royal Adelaide Hospital ( Site 0303)

    Adelaide, South Australia, 5000, Australia

  • Royal Brisbane and Women s Hospital ( Site 0302)

    Herston, Queensland, 4029, Australia

  • Royal Marsden NHS Foundation Trust ( Site 1201)

    Sutton, SM2 5PT, United Kingdom

  • Rush University Medical Center ( Site 0260)

    Chicago, Illinois, 60612, United States

  • SRH Waldklinikum Gera GmbH ( Site 0802)

    Gera, 07548, Germany

  • Samsung Medical Center ( Site 0450)

    Seoul, 06351, South Korea

  • Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0269)

    Seattle, Washington, 98109, United States

  • Seoul National University Bundang Hospital ( Site 0453)

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Severance Hospital Yonsei University Health System ( Site 0452)

    Seoul, 03722, South Korea

  • Sheba MC ( Site 0901)

    Ramat Gan, 5265601, Israel

  • Smilow Cancer Hospital at Yale New Haven ( Site 0256)

    New Haven, Connecticut, 06510, United States

  • St Bartholomew s Hospital ( Site 1205)

    London, EC1A 7BE, United Kingdom

  • St. Francis Hospital Cancer Center ( Site 1461)

    Greenville, South Carolina, 29607, United States

  • St. Joseph Heritage Healthcare ( Site 0254)

    Santa Rosa, California, 95403, United States

  • St. Luke's Cancer Center - Anderson ( Site 0251)

    Easton, Pennsylvania, 18045, United States

  • St. Vincent Healthcare Frontier Cancer Center ( Site 0286)

    Billings, Montana, 59102, United States

  • Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1007)

    Gdynia, 81-519, Poland

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1008)

    Krakow, 31-826, Poland

  • Taichung Veterans General Hospital ( Site 0506)

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital ( Site 0504)

    Taipei, 112, Taiwan

  • Tel Aviv Sourasky Medical Center ( Site 0900)

    Tel Aviv, 6423906, Israel

  • Texas Oncology PA ( Site 8001)

    Longview, Texas, 75601, United States

  • Texas Oncology-Arlington North ( Site 8005)

    Arlington, Texas, 76014, United States

  • Texas Oncology-Austin Central ( Site 8002)

    Austin, Texas, 78731, United States

  • The Cancer Institute Hospital of JFCR ( Site 0357)

    Tokyo, 135-8550, Japan

  • The Ottawa Hospital - Cancer Care ( Site 0052)

    Ottawa, Ontario, K1H 8L6, Canada

  • The Royal Marsden Foundation Trust ( Site 1200)

    London, SW3 6JJ, United Kingdom

  • Tom Baker Cancer Centre ( Site 0063)

    Calgary, Alberta, T2N 4N2, Canada

  • UCLA Medical Center ( Site 0273)

    Los Angeles, California, 90095, United States

  • UMC St. Radboud ( Site 1356)

    Nijmegen, 6525 GA, Netherlands

  • UMCG ( Site 1351)

    Groningen, 9713 GZ, Netherlands

  • UZ Gent ( Site 0650)

    Ghent, 9000, Belgium

  • UZ Leuven Campus Gasthuisberg ( Site 0652)

    Leuven, 3000, Belgium

  • Universitaetsklinik Ulm ( Site 0804)

    Ulm, 89075, Germany

  • Universitaetsklinikum Schleswig-Holstein-Campus Luebeck ( Site 0803)

    Lübeck, 23538, Germany

  • Universitares Cancer Center Hamburg - UCCH ( Site 0811)

    Hamburg, 20246, Germany

  • University Hospital Southampton NHS Foundation Trust ( Site 1203)

    Southampton, SO16 6YD, United Kingdom

  • University Hospital of North Staffordshire ( Site 1202)

    Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom

  • University of California San Francisco ( Site 0274)

    San Francisco, California, 94115, United States

  • University of Massachusetts Memorial Medical Center ( Site 0285)

    Worcester, Massachusetts, 01655, United States

  • University of Michigan Hospital and Health Systems ( Site 0267)

    Ann Arbor, Michigan, 48109, United States

  • University of Rochester - James P. Wilmot Cancer Center ( Site 0255)

    Rochester, New York, 14642, United States

  • University of Virginia Health System ( Site 0261)

    Charlottesville, Virginia, 22908, United States

  • Universitätsklinikum Erlangen ( Site 0801)

    Erlangen, 91054, Germany

  • VU Medisch Centrum ( Site 1352)

    Amsterdam, 1081 HV, Netherlands

  • Willamette Valley Cancer Institute and Research Center ( Site 8000)

    Eugene, Oregon, 97401, United States

  • Zachodniopomorskie Centrum Onkologii ( Site 1013)

    Szczecin, 71-730, Poland

Conditions

Explore the condition pages connected to this study.