Head-to-Head cancer drug showdown: which treatment works best?

NCT ID NCT03358472

Completed Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This completed Phase 3 trial compared three different drug combinations for people with advanced head and neck cancer that had returned or spread. Researchers tested two newer immunotherapy approaches (pembrolizumab alone and with epacadostat) against a standard chemotherapy combination. The goal was to see which treatment was most effective at shrinking tumors and had the fewest side effects for 89 participants.

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Contacts and locations

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Locations

Adana Sehir Hastanesi

Adana, 01370, Turkey (Türkiye)
Allgemeines Krankenhaus der Stadt Wien

Vienna, 1090, Austria
Asan Medical Center

Seoul, 05505, South Korea
Baptist Health

Louisville, Kentucky, 40223, United States
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz

Miskolc, 3526, Hungary
CHU de Quebec-Universite Laval-Hotel Dieu de Quebec

Québec, Quebec, G1R 3S1, Canada
Centro Hospitalar Lisboa Norte EPE - Hospital de Santa Maria

Lisbon, 1649-035, Portugal
Chang Gung Medical Foundation. Linkou

Taoyuan District, 33305, Taiwan
Chris OBrien Lifehouse

Camperdown, New South Wales, 2050, Australia
Ege Universitesi Tip Fakultesi Hastanesi

Izmir, 35040, Turkey (Türkiye)
Hacettepe Universitesi Tip Fakultesi Hastanesi

Ankara, 06100, Turkey (Türkiye)
Hiroshima University Hospital

Hiroshima, 734-8551, Japan
Hokkaido University Hospital

Hokkaido, 060-8648, Japan
Hospital Clinico Lozano Blesa

Zaragoza, 50009, Spain
Hospital General Universitari Vall d Hebron

Barcelona, 08035, Spain
Hospital Germans Trias i Pujol. ICO de Badalona

Badalona, 08916, Spain
Hospital Infanta Cristina

Madrid, 28981, Spain
Hospital Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital de Nuestra Senora de Valme

Seville, 41014, Spain
Huntsman Cancer Institute Univ of Utah

Salt Lake City, Utah, 19026, United States
Hyogo Cancer Center

Akashi, 673-8558, Japan
IRRCS Instituto Clinico Humanitas

Rozzano, 20089, Italy
Inonu Universitesi Turgut Ozal Tip Merkezi

Malatya, 44280, Turkey (Türkiye)
Inst. Portugues de Oncologia de Coimbra Frencisco Gentil EPE

Coimbra, 3000-075, Portugal
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE

Lisbon, 1099-023, Portugal
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE

Porto, 4200-072, Portugal
Istanbul Universitesi Onkoloji Enstitusu

Istanbul, 34093, Turkey (Türkiye)
Istituto Europeo di Oncologia

Milan, 20141, Italy
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet

Szolnok, 5000, Hungary
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Juravinski Cancer Center Hamilton Health Sciences

Hamilton, Ontario, L8V 5C2, Canada
Kanagawa Cancer Center

Yokohama, Kanagawa, 241-8515, Japan
Kanazawa University Hospital

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kindai University Hospital

Sayama, 589-8511, Japan
Kobe City Medical Center General Hospital

Kobe, 650-0047, Japan
Kyushu University Hospital

Fukuoka, 812-8582, Japan
Landeskrankenhaus Salzburg

Salzburg, 5020, Austria
Macquarie University Hospital

North Ryde, New South Wales, 2109, Australia
Mazowiecki Szpital Onkologiczny

Wieliszew, Masovian Voivodeship, 05-135, Poland
Medipol Hastanesi

Istanbul, 34214, Turkey (Türkiye)
Miyagi Cancer Center

Natori-shi, Miyagi, 981-1293, Japan
Musgrove Park Hospital

Taunton, TA1 5DA, United Kingdom
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, 70457, Taiwan
National Taiwan University Hospital

Taipei, 10048, Taiwan
New Mexico Cancer Care Alliance

Albuquerque, New Mexico, 87106, United States
North Middlesex Hospital

London, N18 1QX, United Kingdom
Northwest Georgia Oncology Centers PC

Douglasville, Georgia, 30134, United States
Oklahoma Cancer Specialists and Research

Tulsa, Oklahoma, 74146, United States
Pacific Cancer Medical Center

Anaheim, California, 19026, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Providence Portland Med Center

Portland, Oregon, 97213, United States
Przychodnia Lekarska Komed

Konin, 62-500, Poland
Royal Brisbane & Women s Hospital

Herston, Queensland, 4029, Australia
Saitama Cancer Center

Saitama, 362-0806, Japan
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shizuoka Cancer Center Hospital and Research Institute

Shizuoka, 411-8777, Japan
St. Joseph Heritage Healthcare

Santa Rosa, California, 95403, United States
St. Vincent Healthcare Cancer Ctr

Billings, Montana, 59102, United States
The Cancer Institute Hospital of JFCR

Tokyo, 135-8550, Japan
The Royal Marsden Foundation Trust

London, SW3 6JJ, United Kingdom
The Royal Marsden Nhs Foundation Trust - Chelsea

London, SW3 6JJ, United Kingdom
Tohoku University Hospital

Sendai, Miyagi, 980-8574, Japan
Trakya Universitesi Tip Fakultesi

Edirne, 22030, Turkey (Türkiye)
U of Kansas Cancer Center

Westwood, Kansas, 66205, United States
UC Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University College London Hospitals (UCLH)

London, NW1 2PG, United Kingdom
University of Colorado Cancer Center

Aurora, Colorado, 80045, United States
Viginia Mason Med Ctr

Seattle, Washington, 98101, United States
Yale Cancer Center

New Haven, Connecticut, 06520, United States
Zachodniopomorskie Centrum Onkologii

Szczecin, 71-730, Poland

Conditions

Explore the condition pages connected to this study.

HEAD AND NECK CANCER