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Could gut bacteria explain why salt raises blood pressure?

NCT ID NCT07790900

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study tests whether eating a high-salt diet for one week changes the bacteria in your gut and whether those changes relate to how much your blood pressure rises with salt. Adults aged 50 to 70 will eat both a high-salt and a low-salt diet for one week each, in random order. Researchers will measure blood pressure over 24 hours and analyze stool samples to look for links between gut microbes, inflammation, and salt sensitivity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dietary sodium manipulation (high-salt and low-salt diets)
What this could lead to
If it works, this could reveal how gut bacteria influence salt-related blood pressure changes, potentially pointing toward new ways to prevent or manage hypertension.
What could go wrong
This is a small, early-stage study with only 50 participants, so findings may not apply to everyone. The diets are short-term, and the results may not lead to immediate treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 50 years and ≤ 70 years. 2. Omnivore. 3. Willing to adhere to the study protocol. 4. Able to provide written consent. Exclusion Criteria: 1. Unwilling to make dietary changes or otherwise adhere to the study protocol. 2. Contraindications to high- or low-salt diet (e.g. heart, renal, or liver failure, postural orthostatic tachycardia syndrome) 3. Use of salt tabs, fludricortisone, or midodrine. 4. Contraindications to 24-hour ambulatory blood pressure monitoring, e.g. bilateral upper extremity lymphedema. 5. Medical contraindications to foods, e.g. celiac disease, nut allergy, egg allergy, etc. 6. Systolic blood pressure \< 90 or \> 160 mm Hg or diastolic blood pressure \< 50 or \> 100 mm Hg at screening 7. Current use of anti-hypertensive medications 8. Current use of oral steroids, daily NSAIDS, anti-inflammatory or immune modulating medications, probiotics, or antibiotics. 9. Rheumatologic condition (e.g. Lupus, Rheumatoid Arthritis, Psoriatic arthritis, Inflammatory Bowel Disease, Multiple Sclerosis). 10. Presence of acute or chronic medical conditions not generalizable to the general population (including eating disorders, cancer, severe mental illness, cognitive impairment, pregnancy or lactation).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Salt-sensitivity of blood pressure

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

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