Could the bacteria in your gut shape how pelvic cancer responds to treatment?
NCT ID NCT05605353
First seen Aug 28, 2026 · Last updated Aug 28, 2026
Summary
This study looks at whether the bacteria living in the gut, and the substances they produce, are linked to how well pelvic cancers respond to treatment. Researchers will collect stool and blood samples from about 450 people with bladder, prostate, cervical, ovarian, womb, or colorectal cancer before they start therapy. By comparing the gut bacteria profiles with treatment outcomes, the team hopes to identify which bacteria are helpful. This could one day lead to probiotics or dietary changes that boost those beneficial bacteria during cancer treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- No intervention; this is an observational study collecting stool and blood samples to analyze gut bacteria and metabolites.
- What this could lead to
- If certain gut bacteria are linked to better treatment outcomes, future patients might receive probiotics or dietary changes to improve their response to cancer therapy.
- What could go wrong
- This is an observational study, so it can only show associations, not cause and effect. The findings may not lead to a practical treatment, and results depend on many individual factors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 450 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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May 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
450 patients who have been diagnosed with pelvic neoplasms in the NHS Grampian region of Scotland, United Kingdom
- Ages
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16 to 99 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients willing to consent 2. Any patient who is being treated in NHS Grampian for a pelvic cancer (Colorectal, urological or gynaecological) above 16 years of age Exclusion Criteria: 1. patients who are not willing to consent to be involved 2. Malignancies from other sources or anatomical locations 3. Patients who lack the understanding of the study to obtain appropriate levels of consen
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aberdeen Royal Infirmary
Aberdeen, Scotland, AB25 2ZN, United Kingdom
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