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Grapefruit juice may alter blood thinner effects, small study hints

NCT ID NCT07113054

Ongoing Knowledge-focused Sponsor: Hyewon Chung Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase 1 trial in 14 healthy adults tests whether grapefruit juice changes how the body absorbs and processes the blood thinner edoxaban. Participants take edoxaban alone and then with grapefruit juice to compare drug levels and clotting measures. The goal is to see if grapefruit juice could make the drug more or less potent, which could affect safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
edoxaban and grapefruit juice
What this could lead to
If it works, this could help doctors understand whether grapefruit juice changes how the blood thinner edoxaban works in the body.
What could go wrong
This is a very small, early-phase study in healthy people, not patients. The results may not apply to everyone or lead to any change in medical advice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

  • Korea University Guro Hospital

    Seoul, Seoul, 08308, South Korea

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