Lab-Grown skin patch could heal wounds in 'Butterfly Children'

NCT ID NCT07193134

Recruiting now Disease control Sponsor: CHU de Quebec-Universite Laval Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new skin graft made from a patient's own cells, genetically modified to produce a missing protein. It aims to safely heal wounds in 9 people with recessive dystrophic epidermolysis bullosa (RDEB), a rare disease that causes fragile, blistering skin. The graft is applied after wound cleaning and temporary donor skin, and researchers will monitor healing, pain, and itching for a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: genetically modified skin graft made from the patient's own cells
What this could lead to: If it works, this could provide a lasting way to heal wounds and reduce pain and itching for people with RDEB.
What could go wrong: This is an early-phase trial with only 9 participants, so results may not apply to everyone. The graft uses a virus to modify cells, which carries unknown long-term risks.

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Conditions

The condition(s) this trial relates to.

Collagen Diseases Congenital Abnormalities connective tissue disorder epidermolysis bullosa epidermolysis bullosa dystrophica hereditary disease hereditary skin disorder recessive dystrophic epidermolysis bullosa Skin Abnormalities Skin and Connective Tissue Diseases skin disorder vesiculobullous skin disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPIDERMOLYSIS BULLOSA DYSTROPHICA, RECESSIVE RDEB RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA

Contacts and locations

Locations

The Hospital for Sick Children (SickKids)
RECRUITING

Toronto, Ontario, M5G 1E8, Canada

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