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New hope for lymphoma patients after CAR T-Cell failure

NCT ID NCT04703686

Completed Disease control Sponsor: The Lymphoma Academic Research Organisation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called glofitamab in 67 people with certain types of lymphoma (a blood cancer) that did not respond to or came back after CAR T-cell therapy. Participants received a pre-treatment followed by up to 11 cycles of glofitamab. The goal was to see if this antibody could shrink or control the cancer. The trial is now complete.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma indolent B-cell non-Hodgkin lymphoma mantle cell lymphoma primary mediastinal large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B CELL LYMPHOMA REFRACTORY REFRACTORY INDOLENT ADULT NON-HODGKIN LYMPHOMA REFRACTORY MANTLE CELL LYMPHOMA REFRACTORY PRIMARY MEDIASTINAL LARGE B-CELL CELL LYMPHOMA REFRACTORY TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

  • APHP - Hôpital Saint Antoine

    Paris, France

  • APHP - Hôpital de la Pitiè Salpetrière

    Paris, France

  • CHRU Lille - Hôpital Claude Huriez

    Lille, 59037, France

  • CHU Amiens Picardie Site sud

    Amiens, France

  • CHU Lyon Sud

    Pierre-Bénite, 69130, France

  • CHU Montpellier

    Montpellier, 34295, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU Tours Hopital Bretonneau

    Tours, 37044, France

  • CHU de Bordeaux - Hôpital Haut Leveque

    Pessac, 33604, France

  • CHU de Brabois

    Vandœuvre-lès-Nancy, France

  • CHU de Clermont Ferrand

    Clermont-Ferrand, 63000, France

  • CHU de Dijon - Hôpital le Bocage

    Dijon, 21034, France

  • CHU de Grenoble

    Grenoble, 38043, France

  • CHU de Rennes - Hôpital Pontchaillou

    Rennes, 35033, France

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Hopital Henri Mondor

    Créteil, 94010, France

  • Hopital Necker enfants malades

    Paris, 7574, France

  • Hôpital Saint Louis

    Paris, 75475, France

  • IUCT Oncopole

    Toulouse, 31059, France