New hope for lymphoma patients after CAR T-Cell failure

NCT ID NCT04703686

Completed Disease control Sponsor: The Lymphoma Academic Research Organisation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called glofitamab in 67 people with certain types of lymphoma (a blood cancer) that did not respond to or came back after CAR T-cell therapy. Participants received a pre-treatment followed by up to 11 cycles of glofitamab. The goal was to see if this antibody could shrink or control the cancer. The trial is now complete.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIFFUSE LARGE B CELL LYMPHOMA REFRACTORY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma indolent B-cell non-Hodgkin lymphoma mantle cell lymphoma primary mediastinal large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B CELL LYMPHOMA REFRACTORY REFRACTORY INDOLENT ADULT NON-HODGKIN LYMPHOMA REFRACTORY MANTLE CELL LYMPHOMA REFRACTORY PRIMARY MEDIASTINAL LARGE B-CELL CELL LYMPHOMA REFRACTORY TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

APHP - Hôpital Saint Antoine

Paris, France
APHP - Hôpital de la Pitiè Salpetrière

Paris, France
CHRU Lille - Hôpital Claude Huriez

Lille, 59037, France
CHU Amiens Picardie Site sud

Amiens, France
CHU Lyon Sud

Pierre-Bénite, 69130, France
CHU Montpellier

Montpellier, 34295, France
CHU Nantes

Nantes, 44093, France
CHU Tours Hopital Bretonneau

Tours, 37044, France
CHU de Bordeaux - Hôpital Haut Leveque

Pessac, 33604, France
CHU de Brabois

Vandœuvre-lès-Nancy, France
CHU de Clermont Ferrand

Clermont-Ferrand, 63000, France
CHU de Dijon - Hôpital le Bocage

Dijon, 21034, France
CHU de Grenoble

Grenoble, 38043, France
CHU de Rennes - Hôpital Pontchaillou

Rennes, 35033, France
Centre Henri Becquerel

Rouen, 76038, France
Hopital Henri Mondor

Créteil, 94010, France
Hopital Necker enfants malades

Paris, 7574, France
Hôpital Saint Louis

Paris, 75475, France
IUCT Oncopole

Toulouse, 31059, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.