New hope for lymphoma patients when CAR T-Cells fail

NCT ID NCT04703686

First seen Mar 17, 2026 · Last updated May 12, 2026 · Updated 7 times

Summary

This study tested a drug called glofitamab in 67 people with lymphoma that did not respond or came back after CAR T-cell therapy. Glofitamab is a bispecific antibody that helps the immune system attack cancer cells. The goal was to see if it could control the disease, not cure it. Participants received a pre-treatment drug followed by up to 11 cycles of glofitamab.

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Contacts and locations

Locations

  • APHP - Hôpital Saint Antoine

    Paris, France

  • APHP - Hôpital de la Pitiè Salpetrière

    Paris, France

  • CHRU Lille - Hôpital Claude Huriez

    Lille, 59037, France

  • CHU Amiens Picardie Site sud

    Amiens, France

  • CHU Lyon Sud

    Pierre-Bénite, 69130, France

  • CHU Montpellier

    Montpellier, 34295, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU Tours Hopital Bretonneau

    Tours, 37044, France

  • CHU de Bordeaux - Hôpital Haut Leveque

    Pessac, 33604, France

  • CHU de Brabois

    Vandœuvre-lès-Nancy, France

  • CHU de Clermont Ferrand

    Clermont-Ferrand, 63000, France

  • CHU de Dijon - Hôpital le Bocage

    Dijon, 21034, France

  • CHU de Grenoble

    Grenoble, 38043, France

  • CHU de Rennes - Hôpital Pontchaillou

    Rennes, 35033, France

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Hopital Henri Mondor

    Créteil, 94010, France

  • Hopital Necker enfants malades

    Paris, 7574, France

  • Hôpital Saint Louis

    Paris, 75475, France

  • IUCT Oncopole

    Toulouse, 31059, France

Conditions

Explore the condition pages connected to this study.