New combo aims to tame side effects in Tough-to-Treat lymphoma

NCT ID NCT06806033

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study tests a new drug combination (glofitamab plus gemcitabine and oxaliplatin) in about 100 people with aggressive B-cell lymphoma that has returned or not responded to prior therapy. The main goal is to see if a better steroid plan can reduce a serious side effect called cytokine release syndrome, making it safer to give the treatment without needing a hospital stay.

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Conditions

The condition(s) this trial relates to.

aggressive B-cell non-Hodgkin lymphoma B-cell non-Hodgkin lymphoma cytokine release syndrome diffuse large B-cell lymphoma high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement high-grade B-cell lymphoma double-hit/triple-hit non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL NON-HODGKINS LYMPHOMA DIFFUSE LARGE B CELL LYMPHOMA

Contacts and locations

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Study contacts

Contact
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O. Spedali Civili Di Brescia-P.O. Spedali Civili
ACTIVE_NOT_RECRUITING

Brescia, Lombardy, 25123, Italy
Alaska Oncology & Hematology, LLC
RECRUITING

Anchorage, Alaska, 99508, United States
Arthur J.E. Child Comprehensive Cancer Center
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
ACTIVE_NOT_RECRUITING

Seoul, 05505, South Korea
Baylor Scott & White Health
RECRUITING

Temple, Texas, 76502, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
CAMPUS BENJAMIN FRANKLIN CharitéCentrum 14 Med.Klinik f.Hämatologie u.Onkologie
ACTIVE_NOT_RECRUITING

Berlin, 12200, Germany
CHU DE RENNES - CHU Pontchaillou
WITHDRAWN

Rennes, 35033, France
CHU de Bordeaux
RECRUITING

Pessac, 33600, France
CHU de Grenoble
RECRUITING

La Tronche, 38700, France
Cancer Care Specialists of Central Illinois
RECRUITING

Swansea, Illinois, 62226, United States
CancerCare Manitoba (CCMB)
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Charite-Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK)
ACTIVE_NOT_RECRUITING

Berlin, 13353, Germany
Chu De Tours
RECRUITING

Tours, 37000, France
Chu de Montpellier-St Eloi
RECRUITING

Montpellier, 34295, France
Community Cancer Institute (CCI)
RECRUITING

Clovis, California, 93611, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Epworth Hospital
ACTIVE_NOT_RECRUITING

East Melbourne, Victoria, 3002, Australia
Hematology Oncology Associates of Central New York
RECRUITING

East Syracuse, New York, 13057, United States
IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori"
ACTIVE_NOT_RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
Irccs Istituto Europeo Di Oncologia (IEO)
ACTIVE_NOT_RECRUITING

Milan, Lombardy, 20141, Italy
Istituto Clinico Humanitas
ACTIVE_NOT_RECRUITING

Rozzano, Lombardy, 20089, Italy
Istituto Nazionale Tumori Irccs Fondazione g. Pascale
ACTIVE_NOT_RECRUITING

Naples, Campania, 80131, Italy
Los Angeles Cancer Network
RECRUITING

Glendale, California, 91204, United States
Mary Bird Perkins Cancer Ctr
RECRUITING

Baton Rouge, Louisiana, 70809, United States
Mission Blood and Cancer - MercyOne Cancer Center
RECRUITING

Waukee, Iowa, 50263, United States
Mount Sinai Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33140, United States
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
New York Oncology Hematology, P.C.
RECRUITING

Albany, New York, 12206, United States
North Florida/ South Georgia VA Medical Center
RECRUITING

Gainesville, Florida, 32608, United States
Northwest Medical Specialties
RECRUITING

Tacoma, Washington, 98405, United States
Oncology Associates of Oregon, P.C
RECRUITING

Eugene, Oregon, 97401, United States
Orlando Health Cancer Institute
RECRUITING

Orlando, Florida, 32806, United States
Otto von Guericke Uni Magdeburg Uniklinik
RECRUITING

Magdeburg, 39120, Germany
Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Providence St. Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Aurora, Colorado, 80012, United States
Seoul National University Bundang Hospital
ACTIVE_NOT_RECRUITING

Seongnam-si, 463-707, South Korea
Seoul National University Hospital
WITHDRAWN

Seoul, 03080, South Korea
St Luke?s Cancer Institute
RECRUITING

Boise, Idaho, 83712, United States
Tennessee Oncology
RECRUITING

Chattanooga, Tennessee, 37403, United States
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology - Gulf Coast
RECRUITING

The Woodlands, Texas, 77380, United States
Texas Oncology- Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States
The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente
RECRUITING

Torrance, California, 90502-2006, United States
University of Kentucky - Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
Universitätsklinikum Köln
RECRUITING

Cologne, 50937, Germany
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Valkyrie Clinical Trials
RECRUITING

Panorama City, California, 91402, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates - Virginia Beach
RECRUITING

Virginia Beach, Virginia, 23456, United States
Zuckerberg San Francisco General Hospital
RECRUITING

San Francisco, California, 94110, United States

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