New hope for blood cancer patients: givinostat takes on standard therapy

NCT ID NCT06093672

Recruiting now Disease control Sponsor: Italfarmaco Source: ClinicalTrials.gov ↗

First seen Jan 27, 2026 · Last updated May 14, 2026 · Updated 16 times

Summary

This study tests a new drug, givinostat, against the current standard treatment hydroxyurea in 220 adults with a high-risk form of polycythemia vera, a blood cancer that increases red blood cells. The goal is to see if givinostat better controls blood counts and spleen size without causing dangerous clots or bleeding. Participants will be randomly assigned to one of the two treatments and monitored for about a year.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O.U. Maggiore della Carità
RECRUITING

Novara, Piedmont, 28100, Italy
Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda
RECRUITING

Sofia, Sofia-Grad, 1407, Bulgaria
Albert Schweitzer Ziekenhuis
NOT_YET_RECRUITING

Dordrecht, South Holland, 3318 AT, Netherlands
American Oncology Partners of Maryland, PA
RECRUITING

Bethesda, Maryland, 20852, United States

Contact
Assuta Medical Center
RECRUITING

Tel Aviv, Tel Aviv, 60000, Israel
Azienda Ospedaliera Città della Salute e della Scienza di Torino
RECRUITING

Turin, Piedmont, 10126, Italy
Azienda Ospedaliera Papa Giovanni XXIII
RECRUITING

Bergamo, Lombardy, 24127, Italy

Contact
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Tuscany, 50134, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, Sicily, 90127, Italy
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco di Catania
NOT_YET_RECRUITING

Catania, Sicily, 95123, Italy
Azienda Ospedaliero Universitaria delle Marche
RECRUITING

Ancona, The Marches, 60126, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Azienda Sanitaria Ospedaliera S. Croce e Carle
RECRUITING

Cuneo, Piedmont, 12100, Italy
Azienda Sanitaria Universitaria Friuli Centrale
RECRUITING

Udine, Friuli Venezia Giulia, 33100, Italy
Azienda USL IRCCS di Reggio Emilia
RECRUITING

Reggio Emilia, Emilia-Romagna, 42123, Italy
Belfast City Hospital
WITHDRAWN

Belfast, BT9 7AB, United Kingdom
Bnai Zion Medical Center
TERMINATED

Haifa, 31048, Israel
CHU Amiens Hôpital Sud
RECRUITING

Amiens, Somme, 80054, France
CHU Angers
RECRUITING

Angers, Maine-et-Loire, 49000, France
CHU Nantes
RECRUITING

Nantes, Loire-Atlantique, 44000, France
CHU de Nice
RECRUITING

Nice, Alpes-Maritimes, 6202, France
Carmel Medical Center
TERMINATED

Haifa, 34362, Israel
Centre Hospitalier de Saint-Quentin
RECRUITING

Saint-Quentin, Aisne, 2100, France
Centre Hospitalier de Troyes
RECRUITING

Troyes, Aube, 10000, France
Clinical Center of Vojvodina
RECRUITING

Novi Sad, 21000, Serbia
Clinical Hospital Center Bezanijska Kosa
RECRUITING

Belgrade, 11000, Serbia
Clinical Hospital Center Rijeka
NOT_YET_RECRUITING

Rijeka, 51000, Croatia
Clinical Hospital Center Rijeka - PPDS
RECRUITING

Rijeka, 51000, Croatia
Clinical Hospital Center Zemun
RECRUITING

Belgrade, 11000, Serbia
Clinical Hospital Dubrava
RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Connolly Hospital Blanchardstown
WITHDRAWN

Dublin, 15, Ireland
Cork University Hospital
RECRUITING

Cork, Ireland
Ege Universitesi Tip Fakultesi
RECRUITING

Bornova, İzmir, Turkey (Türkiye)

Contact
Emad Ibrahim, MD, Inc
RECRUITING

Redlands, California, 92373, United States
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, Lombardy, 20122, Italy
Fondazione Policlinico Universitario Campus Bio-Medico di Roma
RECRUITING

Rome, Lazio, 00128, Italy
Gemeinschaftspraxis Hämatologie - Onkologie
RECRUITING

Dresden, Saxony, 01307, Germany
General Hospital Sibenik
NOT_YET_RECRUITING

Šibenik, 22000, Croatia
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
RECRUITING

Reggio Calabria, Calabria, 89133, Italy
Gyor-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház
RECRUITING

Győr, Győr-Moson-Sopron, 9024, Hungary
Hadassah Medical Center - PPDS
TERMINATED

Jerusalem, Jerusalem, 91120, Israel
Hopital d'Argenteuil
RECRUITING

Argenteuil, Île-de-France Region, 95107, France
Hospital General Universitario Dr. Balmis
WITHDRAWN

Alicante, 3010, Spain
Hospital Universitari i Politecnic La Fe de Valencia
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hôpital Bretonneau
RECRUITING

Tours, Indre-et-Loire, 37044, France
Hôpital Saint Louis
RECRUITING

Paris, 75010, France
ICO Badalona-H.U. Germans Trias i Pujol
NOT_YET_RECRUITING

Badalona, Barcelona, 8916, Spain
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Imperial College Healthcare NHS Trust
RECRUITING

London, W12 0HS, United Kingdom
Indywidualna Specjalistyczna Praktyka Lekarska Tomasz Woźny
RECRUITING

Poznan, 60-549, Poland
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
Istituto Tumori "Giovanni Paolo II" I.R.C.C.S.
RECRUITING

Bari, Apulia, 70124, Italy

Contact
Klinikum Wels-Grieskirchen GmbH
RECRUITING

Wels, Upper Austria, 4600, Austria
Landesklinikum Wiener Neustadt
RECRUITING

Wiener Neustadt, Lower Austria, 2700, Austria
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mater Misericordiae University Hospital
RECRUITING

Dublin, 7, Ireland
Medical Park Bahcelievler Hastanesi
ENROLLING_BY_INVITATION

Bahçelievler, Istanbul, Turkey (Türkiye)
Medisch Spectrum Twente
NOT_YET_RECRUITING

Enschede, Overijssel, 7512 KZ, Netherlands
Medizinische Fakultät Mannheim der Universität Heidelberg, Universitätsmedizin Mannheim
RECRUITING

Mannheim, Baden-Wurttemberg, 68167, Germany
Medizinische Universitat Wien (Medical University of Vienna)
RECRUITING

Vienna, State of Vienna, 1090, Austria
Milton Keynes University Hospital
RECRUITING

Milton Keynes, United Kingdom

Contact

Contact
Namik Kemal Universitesi Saglik Uygulama ve Arastirma Merkezi
RECRUITING

Altınova, Terkirdag, Turkey (Türkiye)

Contact

Contact
OncoResearch Lerchenfeld GmbH
RECRUITING

Hamburg, 22081, Germany
Oncology Associates of Oregon, P.C.
RECRUITING

Eugene, Oregon, 97401, United States
Ordensklinikum Linz GmbH Elisabethinen
RECRUITING

Linz, Upper Austria, 4020, Austria
Pilgrim Hospital
RECRUITING

Boston, United Kingdom

Contact

Contact
Southampton General Hospital
RECRUITING

Southampton, United Kingdom

Contact
Spaarne Gasthuis
NOT_YET_RECRUITING

Hoofddorp, North Holland, 2134 TM, Netherlands
Specjalistyczny Szpital im. dra Alfreda Sokołowskiego
RECRUITING

Wałbrzych, 58-309, Poland
Szabolcs-Szatmár-Bereg Vármegyei Oktatókórház
RECRUITING

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Texas Oncology (Webster) - USOR
RECRUITING

Houston, Texas, 77089, United States
Texas Oncology-Denison Cancer Center
RECRUITING

Sherman, Texas, 75090, United States

Contact
The Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
The James Cancer Hospital and Solove Research Institute
RECRUITING

Roanoke, Virginia, 43210, United States
Tolna Vármegyei Megyei Balassa János Kórház
RECRUITING

Szekszárd, Tolna County, 7100, Hungary
US Oncology Inc
RECRUITING

Englewood, Colorado, 80113, United States
University Clinical Center Nis
RECRUITING

Niš, 18000, Serbia
University Clinical Center of Serbia
WITHDRAWN

Belgrade, 11000, Serbia
University Multiprofile Hospital for Active Treatment - Prof. Dr. Stoyan Kirkovich AD
RECRUITING

Stara Zagora, 6003, Bulgaria
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
RECRUITING

Plovdiv, 4001, Bulgaria
University of Alabama at Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35294-0001, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Oxford - The Weatherall Institute of Molecular Medicine (WIMM)
RECRUITING

Oxford, United Kingdom
University of Utah - Huntsman Cancer Institute - PPDS
RECRUITING

Salt Lake City, Utah, 84112, United States
Universitätsmedizin Halle, Universitätsklinikum Halle, Klinik für Innere Medizin IV
WITHDRAWN

Halle, Saxony-Anhalt, 06120, Germany
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza- Radeckiego we Wrocławiu
NOT_YET_RECRUITING

Wroclaw, 50-367, Poland
VA Puget Sound Health Care System - NAVREF - PPDS
RECRUITING

Seattle, Washington, 98108-1532, United States
VM Medical Park Mersin Hospital - Ataturk
RECRUITING

Mezitli, Mersin, Turkey (Türkiye)

Contact

Contact

Conditions

Explore the condition pages connected to this study.

POLYCYTHEMIA VERA