New hope for Tough-to-Treat stomach cancer: Head-to-Head drug battle

NCT ID NCT05734105

Ongoing Disease control Sponsor: Deciphera Pharmaceuticals, LLC Source: ClinicalTrials.gov ↗

Summary

This study compares two drugs, ripretinib and sunitinib, for patients with advanced gastrointestinal stromal tumor (GIST) whose cancer has grown despite initial treatment with imatinib. It specifically targets patients whose tumors have certain genetic mutations. The goal is to see which drug better controls cancer growth and extends survival for this difficult-to-treat group.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AC Camargo Câncer Center

São Paulo, São Paulo, 01509-900, Brazil
Alfred Health

Melbourne, Victoria, 3004, Australia
Arthur J.E. Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center

Seoul, 05505, South Korea
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi

Bologna, 40138, Italy
Boston Medical Center

Boston, Massachusetts, 02118, United States
CEPEN - Centro de Pesquisa e Ensino em Saude de Santa Catarina

Florianópolis, Santa Catarina, 88034-000, Brazil
CHU Dijon

Dijon, Bourgogone, 21079, France
Centre Eugène Marquis

Rennes, Ille et Vilaine, 35000, France
Centre Léon Bérard

Lyon, 69373, France
Centro de Oncología de Precisión

Santiago, RM, 7550000, Chile
China Medical University Hospital

Taichung, 40447, Taiwan
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clínica San Carlos De Apoquindo Red Salud UC Christus

Las Condes, RM, 7620002, Chile
Complejo Hospitalario Universitario de Vigo - Hospital Alvaro Cunqueiro

Vigo, Pontevedra, 36312, Spain
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Heidelberg University Hospital

Heidelberg, 69120, Germany
Helios Klinikum Berlin-Buch

Berlin, Germany
Hospital 9 de Julho

São Paulo, São Paulo, 01409-002, Brazil
Hospital General Universitario Gregorio Marañon

Madrid, 28007, Spain
Hospital Sirio-Libanes

São Paulo, São Paulo, 01308, Brazil
Hospital Universitario Centra de Asturias

Oviedo, 33011, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario Vall d'Hebron

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital de Cancer de Barretos - Fundacao Pio XII

Barretos, São Paulo, 14748-400, Brazil
Hospital de la Santa Creu i Sant Pau

Barcelona, 08041, Spain
INCA - Instituto Nacional de Cancer

Rio de Janeiro, Rio de Janeiro, 20231, Brazil
IRCCS Istituto Clinico Humanitas

Rozzano, 20089, Italy
Institut Bergonié

Bordeaux, 33076, France
Institut Gustave Roussy

Villejuif, 94805, France
Instituto Valenciano de Oncologia - IVO

Valencia, Valencia, 46009, Spain
Istituto Nazionale Tumori IRCCS Fondazione "G Pascale"

Naples, Napoli, 80131, Italy
Istituto Oncologico Veneto-IOV IRCCS

Padua, 35128, Italy
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Juravinski Cancer Centre

Hamilton, Ontario, L8V 5C2, Canada
LUMC

Leiden, 2333 ZA, Netherlands
M Health Fairview University of Minnesota Medical Center

Minneapolis, Minnesota, 55455, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
McGill University Health Centre

Montreal, Quebec, H4A 3J1, Canada
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii Im . Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Warsaw, Warszawa, 02-781, Poland
National Taiwan University Hospital

Taipei, 10002, Taiwan
Northwell Health Cancer Institute/ R.J. Zuckerberg Cancer Center

New York, New York, 11042, United States
OU Health Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Oslo University Hospital

Oslo, Norway, 0379, Norway
Prince of Wales Hospital

Randwick, New South Wales, 2031, Australia
Samsung Medical Center

Seoul, 06351, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
St. James University Hospital

Leeds, West Yorkshire, LS9 7TF, United Kingdom
Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
The Royal Marsden Hospital NHS Foundation Trust

London, Greater London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
U.O.C. Oncologia Medica

Palermo, Palermo, 90127, Italy
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UMC Groningen

Groningen, 9713, Netherlands
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
Universitares Krebszentrum Leipzig

Leipzig, 04103, Germany
University Health Network, Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
University Hospital Essen (Universitätsklinikum Essen)

Essen, 45147, Germany
University of Virginia

Charlottesville, Virginia, 22908, United States
Università Campus Bio-Medico di Roma

Roma, 00128, Italy
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

GIST