New hope for Tough-to-Treat stomach tumors in major trial

NCT ID NCT05208047

Ongoing Disease control Sponsor: Cogent Biosciences, Inc. Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding a new drug called CGT9486 to an existing cancer drug (sunitinib) works better than sunitinib alone for people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The study will enroll about 442 patients whose cancer has worsened after initial treatment. The main goal is to see if the combination helps patients live longer without their cancer getting worse.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AP-HM - Hôpital de la Timone

Marseille, 13005, France
ASST degli Spedali Civili di Brescia

Brescia, 25123, Italy
Aarhus University Hospital

Aarhus, 8200, Denmark
Alberta Health Services Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Asan Medical Center

Seoul, 05505, South Korea
Azienda Ospedaliera Universitaria Integrata Verona-Ospedale Borgo Trento

Verona, 31726, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

Palermo, 90127, Italy
Azienda Ospedaliero-Universitaria Careggi

Florence, 50134, Italy
Bankstown-Lidcombe Hospital

Bankstown, 2200, Australia
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

São Paulo, 09060-650, Brazil
CHU de Toulouse - Hospital Rangueil

Toulouse, 31400, France
Cambridge Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Centre Eugene Marquis

Rennes, 35042, France
Centre Leon Berard

Lyon, 69008, France
Centre Oscar Lambret

Lille, 59000, France
Centro Riferimento Oncologico - Aviano

Aviano, 33081, Italy
Centro de Oncologia de Precision, Universidad Mayor

Santiago, 7560908, Chile
Chang Gung Memorial Hospital - Kaohsiung Branch

Kaohsiung City, 83301, Taiwan
Chang Gung Memorial Hospital - Linkou Branch (CGMHLK)

Taoyuan District, 33305, Taiwan
China Medical University Hospital

Taichung, 40447, Taiwan
City of Hope

Duarte, California, 91010, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Debreceni Egyetem, Klinikai Központ, Onkológiai Klinika

Debrecen, 4032, Hungary
Duke University

Durham, North Carolina, 27705, United States
Erasmus MC

Rotterdam, 3015 GD, Netherlands
Fakultni nemocnice Olomouc - Oncology clinic

Olomouc, 77900, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Gustave Roussy

Villejuif, 94805, France
Haukeland University Hospital - Bergen

Bergen, 5021, Norway
Helios Klinikum Bad Saarow

Bad Saarow, 15526, Germany
Helios Klinikum Berlin-Buch

Berlin, 13125, Germany
Hong Kong United Oncology Centre

Jordon, Hong Kong
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Clinico Universitario de Santiago de Compostela

Santiago de Compostela, 15706, Spain
Hospital Fundación Jiménez Díaz

Madrid, 28040, Spain
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital das Clinicas da Universidade Estadual de Campinas (UNICAMP)

Campinas, 130.83-888, Brazil
I Can Oncology Center SA De CV

Monterrey, 64710, Mexico
ICO St-Herblain

Saint-Herblain, 44800, France
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola

Bologna, 40138, Italy
Institut Bergonie

Bordeaux, 33076, France
Institut Catala d'Oncologia - L'Hospitalet

Barcelona, 08908, Spain
Instituto Alexander Fleming

Buenos Aires, C1426ANZ, Argentina
Instituto Oncologico FALP

Santiago, 7500921, Chile
Instituto Oncologico de Cordoba (IONC)

Córdoba, X5000HWE, Argentina
Istituto Clinico Humanitas

Rozzano, 20089, Italy
Istituto Europeo di Oncologia

Milan, 20141, Italy
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"

Meldola, 47014, Italy
Karolinska University Hospital

Solna, 171 76, Sweden
Korea University Guro Hospital

Seoul, 08308, South Korea
Masarykuv onkologicky ustav

Brno, 65653, Czechia
Mayo Clinic

Scottsdale, Arizona, 85259, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medizinische Hochschule Hannover- Urology Oncology

Hanover, 30625, Germany
Memorial Sloan Kettering Cancer Center

New York, New York, 10021, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Klinika Nowotworow Tkanek Miekkich, Kosci i Czerniakow

Warsaw, 02-781, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Oddzial w Gliwicach, Oddzial Chemioterapii Dziennej

Gliwice, 44-102, Poland
National Taiwan University Hospital

New Taipei City, 10002, Taiwan
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)

Amsterdam, 1066 CX, Netherlands
Northwestern University

Chicago, Illinois, 60611, United States
Oregon Health & Science University (OHSU)

Portland, Oregon, 97239, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Oslo University Hospital

Oslo, 0310, Norway
Policlinico Universitario Campus Bio-Medico

Roma, 00128, Italy
Prince of Wales Hospital

Shatin, Hong Kong
Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
Roswell Park Comprehensive Cancer Center

Buffalo, New York, 14203, United States
Royal Marsden Hospital - Surrey

London, SW3 6JJ, United Kingdom
Samsung Medical Center

Seoul, 06351, South Korea
Seoul National University Hosptial

Seoul, 03080, South Korea
Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, S10 2SJ, United Kingdom
Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
Skane University Hospital Lund

Lund, 22185, Sweden
Stichting Radboud Universitair Medisch Centrum

Nijmegen, 6525 GA, Netherlands
Szpital Specjalistyczny w Brzozowie

Brzozów, 36-200, Poland
Taipei Veterans General Hospital (VGHTP)

Taipei, 11217, Taiwan
The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
The Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030-4009, United States
Tom Baker Cancer Center

Calgary, T2N 4N2, Canada
UMC Groningen

Groningen, 9713 GZ, Netherlands
Universitaetsklinikum Essen

Essen, 45147, Germany
Universitaetsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany
Universitaetsmedizin Mannheim

Mannheim, 68167, Germany
Universite de Montreal - Hopital Maisonneuve-Rosemont (HMR)

Montreal, HIT 2M4, Canada
University College London Hospital

London, NW1 2PG, United Kingdom
University of Arizona- Cancer Center

Tucson, Arizona, 85719, United States
University of California, Los Angeles (UCLA)

Los Angeles, California, 90404, United States
University of California, San Diego (UCSD)

San Diego, California, 92093, United States
University of California, San Francisco

San Francisco, California, 94158, United States
University of Colorado Denver

Denver, Colorado, 80204, United States
University of Iowa Hospital and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Miami - Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh Medical Center - Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Wisconsin - Carbone Cancer Center

Madison, Wisconsin, 53705, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University

St Louis, Missouri, 63130, United States
lnstituto Nacional de Cancer - INCA

Rio de Janeiro, 20.230-130, Brazil

Conditions

Explore the condition pages connected to this study.

ADVANCED GASTROINTESTINAL STROMAL TUMORS METASTATIC CANCER