New drug shows promise for controlling dangerous blood vessel inflammation

NCT ID NCT03725202

Summary

This study tested whether adding the medication upadacitinib to steroid treatment could help people with giant cell arteritis achieve and maintain remission. 429 participants with this inflammatory blood vessel condition were randomly assigned to receive either the study drug or a placebo alongside a tapering steroid schedule. The main goal was to see if more people could stay in remission for a full year while using less steroid medication.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 424 General MILITARY Hospital /ID# 210973

    Efkarpia (Thessalonikis), Thessaloniki, 56429, Greece

  • Aarhus University Hospital /ID# 171177

    Aarhus C, Central Jutland, 8000, Denmark

  • Allen Arthritis /ID# 225527

    Allen, Texas, 75013, United States

  • Aotearoa Clinical Trials /ID# 201942

    Papatoetoe, Auckland, 2025, New Zealand

  • Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 204702

    Glendale, Arizona, 85306-9802, United States

  • Arthritis Associates of Kingsport /ID# 212756

    Kingsport, Tennessee, 37660, United States

  • Arthritis and Rheumatology /ID# 170295

    Atlanta, Georgia, 30342, United States

  • Arthritis and Rheumatology Institute, PLLC /ID# 214612

    Plano, Texas, 75093-6419, United States

  • Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 212761

    Summerville, South Carolina, 29486-7887, United States

  • Aurora Rheumatology and Immunotherapy Center /ID# 201853

    Franklin, Wisconsin, 53132, United States

  • Axon Clinical, s.r.o. /ID# 202468

    Prague, 140 00, Czechia

  • Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 200082

    Udine, 33100, Italy

  • Azienda Ospedaliero-Universitaria di Modena /ID# 200079

    Modena, 41124, Italy

  • Azienda Sanitaria dell'Alto Adige /ID# 200081

    Bolzano, 39100, Italy

  • Barts Health NHS Trust /ID# 210511

    London, Greater London, E1 2ES, United Kingdom

  • Baylor Scott & White Center for Diagnostic Medicine /ID# 213529

    Temple, Texas, 76508, United States

  • Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 204018

    Budapest, 1023, Hungary

  • Bnai Zion Medical Center /ID# 240733

    Haifa, H_efa, 3339419, Israel

  • CGM Research Trust /ID# 224061

    Christchurch Central, 8011, New Zealand

  • CHRU Lille - Hopital Claude Huriez /ID# 171543

    Lille, Nord, 59037, France

  • CHRU Tours - Hopital Trousseau /ID# 245232

    Chambray-lès-Tours, 37170, France

  • CHU Dijon /ID# 225277

    Dijon, Cote-d Or, 21000, France

  • CHU Toulouse - Hopital Purpan /ID# 171547

    Toulouse, Haute-Garonne, 31059, France

  • CHU de CAEN - Hopital de la Cote de Nacre /ID# 171539

    Caen, 14033, France

  • CHU de Nantes, Hotel Dieu -HME /ID# 171544

    Nantes, Pays de la Loire Region, 44000, France

  • CISSSBSL -Hopital regional de Rimouski /ID# 224266

    Rimouski, Quebec, G5L 5T1, Canada

  • Cabinet Medical Dr. Avram S.R.L /ID# 224336

    Timișoara, Timiș County, 300134, Romania

  • Carilion Clinic /ID# 212928

    Roanoke, Virginia, 24016, United States

  • Centre de Recherche Musculo-Squelettique /ID# 201224

    Trois-Rivières, Quebec, G8Z 1Y2, Canada

  • Clinical Research of West Florida - Tampa /ID# 201899

    Tampa, Florida, 33606-1246, United States

  • Clinical Research of West Florida, Inc /ID# 201901

    Tampa, Florida, 33606-1246, United States

  • Clinical Rheumatologic Hospital No 25 /ID# 208950

    Saint Petersburg, 190068, Russia

  • Clinvest Research LLC /ID# 208182

    Springfield, Missouri, 65807, United States

  • Complejo Hospitalario Universitario A Coruña /ID# 224731

    A Coruña, A Coruna, 15006, Spain

  • Ctr Arthritis & Rheumatic Dise /ID# 168667

    Miami, Florida, 33173, United States

  • Debreceni Egyetem-Klinikai Kozpont /ID# 201526

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Del-Budai Centrumkorhaz Szent Imre Egyetemi Oktatokorhaz /ID# 201838

    Budapest, 1115, Hungary

  • Denver Arthritis Clinic /ID# 171552

    Denver, Colorado, 80230, United States

  • Drammen Sykehus /ID# 201560

    Drammen, Buskerud, 3004, Norway

  • Duplicate_AA Medical Research Center - Grand Blanc /ID# 201854

    Grand Blanc, Michigan, 48439, United States

  • Duplicate_Danderyds sjukhus /ID# 171404

    Stockholm, 182 88, Sweden

  • Duplicate_Erasmus Medisch Centrum /ID# 201717

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Duplicate_Japanese Red Cross Kumamoto Hospital /ID# 203507

    Kumamoto, Kumamoto, 861-8520, Japan

  • Duplicate_Jichi Medical University Hosp /ID# 200169

    Shimotsuke-shi, Tochigi, 329-0431, Japan

  • Duplicate_Rush University Medical Center /ID# 224581

    Chicago, Illinois, 60612, United States

  • Duplicate_University of Alberta Hospital - Division of Hematology /ID# 208629

    Edmonton, Alberta, T6G 2B7, Canada

  • Duplicate_University of South Florida /ID# 207077

    Tampa, Florida, 33612-2201, United States

  • Duplicate_Vastmanlands Sjukhus /ID# 171429

    Västerås, 723 35, Sweden

  • Duplicate_West Michigan Rheumatology /ID# 168647

    Grand Rapids, Michigan, 49546, United States

  • Duplicate_Western Connecticut Health Network- Germantown Rd /ID# 205071

    Danbury, Connecticut, 06810-5038, United States

  • Emeritus Research /ID# 201938

    Camberwell, Victoria, 3124, Australia

  • Emeritus Research Sydney /ID# 201937

    Botany, New South Wales, 2019, Australia

  • Euromedservice /ID# 205345

    Pushkin, 196603, Russia

  • Fakultni nemocnice Olomouc /ID# 202041

    Olomouc, 779 00, Czechia

  • Fiona Stanley Hospital /ID# 201941

    Murdoch, Western Australia, 6150, Australia

  • First Moscow State Medical University n.a I.M. Sechenov /ID# 203673

    Moscow, 119992, Russia

  • Froedtert Memorial Lutheran Hospital /ID# 224557

    Milwaukee, Wisconsin, 53226-3522, United States

  • General Hospital of Athens Gennimatas /ID# 210129

    Athens, Attica, 11527, Greece

  • General Hospital of Athens Ippokratio /ID# 202181

    Athens, Attica, 11527, Greece

  • Griffith University /ID# 223829

    Southport, Queensland, 4222, Australia

  • HCL - Hopital de la Croix-Rousse /ID# 211184

    Lyon, Rhone, 69004, France

  • HFR Fribourg - Hôpital cantonal /ID# 201114

    Fribourg, 1708, Switzerland

  • Haukeland universitetssjukehus /ID# 201602

    Bergen, Hordaland, 5021, Norway

  • Henry Ford Medical Center - New Center One /ID# 207456

    Detroit, Michigan, 48202-3046, United States

  • Hopital Pitie Salpetriere /ID# 171542

    Paris, Île-de-France Region, 75013, France

  • Hopital Saint Joseph /ID# 171540

    Marseille, Bouches-du-Rhone, 13008, France

  • Hopital de la Cavale Blanche /ID# 171549

    Brest, Finistere, 29200, France

  • Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 171545

    Paris, Paris, 75679, France

  • Hospital Clinic de Barcelona /ID# 201878

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos /ID# 204871

    Madrid, 28040, Spain

  • Hospital General Universitario Gregorio Maranon /ID# 201326

    Madrid, 28007, Spain

  • Hospital Meixoeiro (CHUVI) /ID# 212084

    Vigo, Pontevedra, 36213, Spain

  • Hospital Universitario Basurto /ID# 224730

    Bilbao, Vizcaya, 48013, Spain

  • Hospital Universitario Canarias /ID# 224928

    San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320, Spain

  • Hospital Universitario La Paz /ID# 241848

    Madrid, 28046, Spain

  • Hospital Universitario Marques de Valdecilla /ID# 201604

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Virgen de las Nieves /ID# 224726

    Granada, 18014, Spain

  • IRIS Research and Development, LLC /ID# 169406

    Plantation, Florida, 33324, United States

  • Immanuel Krankenhaus Berlin /ID# 223855

    Buch, 13125, Germany

  • Inselspital, Universitaetsspital Bern /ID# 201364

    Bern, 3010, Switzerland

  • Institute of Arthritis Research /ID# 168490

    Idaho Falls, Idaho, 83404, United States

  • Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 202946

    Nagoya, Aichi-ken, 455-8530, Japan

  • Kadlec Clinic Rheumatology /ID# 201618

    Kennewick, Washington, 99336, United States

  • Kagawa University Hospital /ID# 200171

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kantonsspital St. Gallen /ID# 201134

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

  • Karolinska University Hospital Solna /ID# 204945

    Solna, Stockholm County, 171 64, Sweden

  • Kemerovo State Medical University /ID# 203676

    Kemerovo, Kemerovo Oblast, 650056, Russia

  • Lakes Research, LLC /ID# 210442

    Miami, Florida, 33014, United States

  • Liverpool University University Hospitals NHS Foundation Trust /ID# 240391

    Liverpool, L9 7AL, United Kingdom

  • Louisiana State Univ HSC /ID# 202646

    Shreveport, Louisiana, 71130, United States

  • Lovelace Scientific Resources /ID# 169041

    Venice, Florida, 34292, United States

  • Marietta Memorial Hospital /ID# 210834

    Marietta, Ohio, 45750-1635, United States

  • Medallion Clinical Research Institute, LLC /ID# 168666

    Naples, Florida, 34102, United States

  • Medical Plus, s.r.o. /ID# 200865

    Uherské Hradiště, 686 01, Czechia

  • Medisch Centrum Leeuwarden /ID# 201716

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • Medius Klinik Kirchheim /ID# 200637

    Kirchheim unter Teck, Baden-Wurttemberg, 73230, Germany

  • Medizinische Hochschule Hannover /ID# 200632

    Hanover, 30625, Germany

  • Medizinische Universitaet Innsbruck /ID# 201786

    Innsbruck, Tyrol, 6020, Austria

  • Medizinische Versorgungszentren Burghausen Altoetting /ID# 208773

    Burghausen, 84489, Germany

  • Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 221643

    Moscow, Moscow Oblast, 129110, Russia

  • Ochsner Clinic Foundation /ID# 200723

    Baton Rouge, Louisiana, 70836-6455, United States

  • Ochsner Clinic Foundation-New Orleans /ID# 171200

    New Orleans, Louisiana, 70121, United States

  • Okayama University Hospital /ID# 203156

    Okayama, Okayama-ken, 700-8558, Japan

  • Omega Research Group /ID# 201903

    Orlando, Florida, 32808, United States

  • Optimal Clinical Trials Ltd /ID# 201946

    Grafotn, Auckland, 1010, New Zealand

  • Orszagos Reumatologiai es Fizioterapias Intezet /ID# 211454

    Budapest, 1023, Hungary

  • Physician Research Collaboration, LLC /ID# 168610

    Lincoln, Nebraska, 68516, United States

  • Piedmont Arthritis Clinic, PA /ID# 212431

    Greenville, South Carolina, 29601, United States

  • Porter Rheumatology Ltd /ID# 223830

    Nelson, 7010, New Zealand

  • Portsmouth Hospitals University NHS Trust /ID# 225002

    Portsmouth, PO6 3LY, United Kingdom

  • Practicheskaya Medicina Clinic /ID# 224612

    Moscow, 115372, Russia

  • Precision Comprehensive Clinical Research Solutions /ID# 201798

    Colleyville, Texas, 76034, United States

  • Prince of Wales Hospital /ID# 210995

    Randwick, New South Wales, 2031, Australia

  • Radboud Universitair Medisch Centrum /ID# 212925

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Rheum Assoc of North Alabama /ID# 168668

    Huntsville, Alabama, 35801, United States

  • Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 201781

    Vienna, Vienna, 1100, Austria

  • Rheumatology Associates /ID# 201843

    Saskatoon, Saskatchewan, S7K 0H6, Canada

  • Rheumatology Associates PA - Portland /ID# 225011

    Portland, Maine, 04102-2643, United States

  • Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 169040

    Boca Raton, Florida, 33486, United States

  • Rikshospitalet OUS HF /ID# 202004

    Oslo, 0450, Norway

  • Robin K. Dore MD, Inc /ID# 201950

    Tustin, California, 92780, United States

  • Royal Devon & Exeter Hospital /ID# 202834

    Exeter, Devon, EX2 5DW, United Kingdom

  • Royal United Hospitals Bath /ID# 239850

    Bath, Bath And North East Somerset, BA1 3NG, United Kingdom

  • STAT Research, Inc. /ID# 200436

    Vandalia, Ohio, 45377-9464, United States

  • Sahlgrenska Universitetssjukhuset /ID# 171405

    Gothenburg, Västra Götaland County, 413 46, Sweden

  • Sakai City Medical Center /ID# 202643

    Sakai-shi, Osaka, 593-8304, Japan

  • Skane University hospital /ID# 171407

    Malmo, Skåne County, 214 28, Sweden

  • Southend Hospital /ID# 202839

    Southend, SS0 0RY, United Kingdom

  • Spitalul Clinic Colentina /ID# 204889

    Bucharest, 020121, Romania

  • Spitalul Clinic Judetean de Urgenta Cluj -Napoca /ID# 204887

    Cluj-Napoca, Cluj, 400006, Romania

  • Spitalul Clinic Sf. Maria /ID# 203809

    Bucharest, 011172, Romania

  • St. Joseph's Healthcare /ID# 204160

    Hamilton, Ontario, L8N 4A6, Canada

  • St. Marianna University Hospital /ID# 218692

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • St.Luke's International Hospital /ID# 200170

    Chuo-ku, Tokyo, 104-8560, Japan

  • Sydvestjysk Sygehus /ID# 200216

    Esbjerg, Region Syddanmark, 6700, Denmark

  • Tekton Research, L.L.C /ID# 201801

    Austin, Texas, 78745, United States

  • The Arthritis & Diabetes Clinic, Inc. /ID# 171199

    Monroe, Louisiana, 71203, United States

  • The Center for Rheumatology and Bone Research /ID# 168652

    Wheaton, Maryland, 20902, United States

  • The Chaim Sheba Medical Center /ID# 241041

    Ramat Gan, Tel Aviv, 5265601, Israel

  • The Lady Davis Carmel Medical Center /ID# 240731

    Haifa, H_efa, 34362, Israel

  • The Queen Elizabeth Hospital /ID# 201939

    Woodville South, South Australia, 5011, Australia

  • Timaru Medical Specialists Ltd /ID# 201943

    Timaru, Canterbury, 7910, New Zealand

  • Tohoku University Hospital /ID# 200172

    Sendai, Miyagi, 9808574, Japan

  • Tomishiro Central Hospital /ID# 203897

    Tomigusuku-shi, Okinawa, 901-0243, Japan

  • Torbay and South Devon Nhs Foundation Trust /Id# 224689

    Torquay, TQ2 7AA, United Kingdom

  • UH Coventry & Warwickshire /ID# 202838

    Coventry, Warwickshire, CV2 2DX, United Kingdom

  • UZ Gent /ID# 202778

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Unidade Local de Saude de Gaia/Espinho, EPE /ID# 208151

    Vila Nova de Gaia, Porto District, 4434-502, Portugal

  • Unidade Local de Saude de Santa Maria, EPE /ID# 203530

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saúde da Guarda, EPE /ID# 224878

    Guarda, 6300-035, Portugal

  • Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 205186

    Ponte de Lima, Viana do Castelo District, 4990-041, Portugal

  • Universitaetsklinikum Tuebingen /ID# 223854

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitaetsklinikum Wuerzburg /ID# 213340

    Würzburg, Bavaria, 97080, Germany

  • Universitair Medisch Centrum Groningen /ID# 201715

    Groningen, 9713 GZ, Netherlands

  • Universitair Ziekenhuis Leuven /ID# 202779

    Leuven, Vlaams-Brabant, 3000, Belgium

  • University Clinical Research Center /ID# 202504

    Somerset, New Jersey, 08873-3448, United States

  • University Hospitals Dorset NHS Foundation Trust /ID# 202836

    Poole, Dorset, BH15 2JB, United Kingdom

  • University of Michigan Hospitals /ID# 168645

    Ann Arbor, Michigan, 48109-5008, United States

  • University of Pennsylvania /ID# 168655

    Philadelphia, Pennsylvania, 19104-5502, United States

  • University of Rochester Medical Center /ID# 213527

    Rochester, New York, 14642, United States

  • University of Vermont Medical Center /ID# 211179

    Burlington, Vermont, 05401-1473, United States

  • University of Washington /ID# 201619

    Seattle, Washington, 98109, United States

  • Universitätsspital Basel /ID# 201767

    Basel Town, Canton of Basel-City, 4031, Switzerland

  • Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 224334

    Yvoir, Namur, 5530, Belgium

  • Uppsala University Hospital /ID# 171403

    Uppsala, Uppsala County, 75185, Sweden

  • VA Long Beach Healthcare System /ID# 203833

    Long Beach, California, 90822-5201, United States

  • Waikato Hospital /ID# 201944

    Hamilton, Waikato Region, 3240, New Zealand

  • Wayne State University Health Center /ID# 212755

    Detroit, Michigan, 48201-2153, United States

  • West Tennessee Research Institute /ID# 209256

    Jackson, Tennessee, 38305, United States

  • West Texas Clinical Research /ID# 204834

    Lubbock, Texas, 79424, United States

  • ZiekenhuisGroep Twente /ID# 200038

    Almelo, Overijssel, 7609 PP, Netherlands

  • Zuyderland Medisch Centrum /ID# 224551

    Heerlen, Limburg, 6419 PC, Netherlands

Conditions

Explore the condition pages connected to this study.