New hope for Hard-to-Treat cancers: targeted drug enters human trials

NCT ID NCT06500676

Recruiting now Disease control Sponsor: Genfleet Therapeutics (Shanghai) Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called GFH375 in people with advanced solid tumors that have a specific genetic change (KRAS G12D). The goal is to see if the drug is safe, tolerable, and can shrink tumors. About 407 adults aged 18 to 75 with advanced cancers like lung or pancreatic cancer will take part. The drug is taken by mouth and aims to block a key cancer growth signal.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS KRAS G12D MUTATIONS

Contacts and locations

Locations

Cancer Hospital, Chinese Academy of Medical Sciences
RECRUITING

Beijing, Beijing Municipality, China
Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITING

Nanning, Guangxi, China
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Haerbin, Heilongjiang, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, China
Jiangsu Province Hospital
RECRUITING

Nanjing, Jiangsu, China
Liaoning Cancer Hospital & Institute
NOT_YET_RECRUITING

Shenyang, Liaoning, China
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, China
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, China
Shanghai Chest Hospital
RECRUITING

Shanhai, Shanghai Municipality, 201210, China
Sichuan Cancer Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, China
The First Affiliated Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITING

Hefei, Anhui, China
The First Affiliated Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Henan, China
The Second Affiliated Hospital Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, China
The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, China
Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITING

Tianjing, Tianjing, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, China

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