Could a new pill curb alcohol cravings? early trial tests GET73

NCT ID NCT04831684

First seen Jan 29, 2026 · Last updated Jun 19, 2026 · Updated 22 times

Summary

This study tested a drug called GET73 in 79 people with alcohol use disorder who were not seeking treatment. Participants took GET73 or a placebo for 8 days and had MRI scans to see how their brains reacted to alcohol cues. The goal was to see if GET73 could reduce drinking and change brain chemistry related to alcohol cravings.

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Contacts and locations

Locations

  • Charleston Alcohol Research Center, Institute of Psychiatry, Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

GET73

What this could lead to

If it works, this could point toward a new medication to help people with alcohol use disorder drink less or control their cravings.

What could go wrong

This was a small, early-phase trial (Phase 1/2) with only 79 participants and short-term dosing (8 days). The results may not apply to everyone, and the drug may not work as hoped in larger studies.

Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.