Why do some kids respond to growth hormone? scientists look to genetics

NCT ID NCT05894876

Terminated Knowledge-focused Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at children with idiopathic short stature (short stature with no known cause) who had already received growth hormone therapy for at least a year. Researchers compared the genetic profiles of those who responded well to treatment versus those who did not. The goal was to find genetic differences that might explain why some children benefit more from growth hormone. No new treatments were given as part of this study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors predict which children with idiopathic short stature will benefit from growth hormone therapy.
What could go wrong: The study was terminated early with only 43 participants, so results may be limited and not conclusive. It is an observational study, not a treatment trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

isolated short stature

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC SHORT STATURE

Contacts and locations

Locations

Assuta Ashdod Division of Pediatric Endocrinology and Diabetes

Ashdod, Israel
Novo Nordisk Investigational Site

Columbia, Maryland, 21044, United States
University of Sao Paulo School of Medicine

São Pauloa, 05403-908, Brazil
[Legal] Children's Hospital of Orange County on behalf of CHOC Children's Hospital of Orange County

Orange, California, 92868, United States

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