One-Shot gene therapy aims to replace monthly eye injections for vision loss

NCT ID NCT05657301

Summary

This early-stage study is testing the safety of a new gene therapy called KH631 for people with 'wet' age-related macular degeneration (AMD), a leading cause of vision loss. The therapy is designed as a one-time injection into the eye to help the body block a protein that causes harmful blood vessel growth, potentially reducing the need for frequent anti-VEGF injections. The study will enroll about 25 participants to find a safe dose and monitor them for side effects over two years.

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Contacts and locations

Locations

  • Kanghong Investigative Site

    Phoenix, Arizona, 85016, United States

  • Kanghong Investigative Site

    Lemont, Illinois, 60439, United States

  • Kanghong Investigative Site

    Boston, Massachusetts, 02114, United States

  • Kanghong Investigative Site

    Reno, Nevada, 89502, United States

  • Kanghong Investigative Site

    Cherry Hill, New Jersey, 08034, United States

  • Kanghong Investigative Site

    Germantown, Tennessee, 38138, United States

  • Kanghong Investigative Site

    Dallas, Texas, 75231, United States

Conditions

Explore the condition pages connected to this study.