New gene therapy trial aims to reboot immune system against tough cancers

This early-phase study is testing a new personalized treatment for adults with advanced ovarian cancer and other solid tumors that have come back or stopped responding to standard therapies. Doctors will modify a patient's own immune cells in a lab to better recognize and attack their cancer, then give them back along with a low-dose chemotherapy drug. The main goals are to find a safe dose and see if this approach can shrink tumors in people who have run out of other options.