First human test of gene therapy for inherited dementia begins
NCT ID NCT04408625
Summary
This is an early-stage study testing a new gene therapy called LY3884963 for people with a specific genetic form of frontotemporal dementia (FTD). The main goals are to check if the treatment is safe and to see if it can increase levels of a protective protein in the brain and spinal fluid that is low in these patients. The study will follow 35 participants for up to 5 years to monitor their health and track changes in disease-related markers.
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Contacts and locations
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Locations
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AP-HM Hôpital de La Timone
Saint-Pierre, Marseille, 13386, France
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Centre Mémoire de Ressources
Lille, 59000, France
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Hospital Clinic de Barcelona, Villaroel 170 Servicio de Neurología
Barcelona, 08036, Spain
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Hospital Universitario de Donostia, Servicio De Neurologia, Consultas Externas Neurologia, San Sebastian, Guipúzcoa
Donostia / San Sebastian, 20014, Spain
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Hospital of the University of Pennsylvania, 3 West Gates Building, 3400 Spruce Street
Philadelphia, Pennsylvania, 19104, United States
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Lahey Hospital & Medical Center, 41 Burlington Mall Road
Burlington, Massachusetts, 01805, United States
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Le Ber, Institut du Cerveau et de la Moelle Epinière
Paris, 75013, France
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PPD Phase 1 Clinic, 100 West Gore Street, Suite 202
Orlando, Florida, 32806, United States
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Royal Prince Alfred Hospital, Brain & Mind Research Institute, 94 Mallet Street
Camperdown, New South Wales, 2050, Australia
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UZ Leuven, Neurologie Herestraat 49
Leuven, 3000, Belgium
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University College London,Queen Square, Dementia Research Building, London,
London, WC1N 3BG, United Kingdom
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k2 Medical Research-Maitland
Maitland, Florida, 32751-5669, United States
Conditions
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