One-Time gene shot aims to stop bleeding in hemophilia a

NCT ID NCT06833983

Recruiting now Disease control Sponsor: Gritgen Therapeutics Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a single-dose gene therapy called GS1191-0445 in 50 Chinese men with hemophilia A. The treatment uses a harmless virus to deliver a working gene to the liver, helping the body produce its own clotting factor. The goal is to reduce bleeding episodes and the need for regular factor infusions. Participants will be monitored for safety and effectiveness over one year.

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Conditions

The condition(s) this trial relates to.

hemophilia A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMOPHILIA A

Contacts and locations

Locations

Anhui Provincial Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230001, China
Central Hospital Affiliated to Shandong First Medical University
RECRUITING

Jinan, Shandong, 250013, China
First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, 730099, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College
RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Jiangxi Provincial People's Hospital
NOT_YET_RECRUITING

Nanchang, Jiangxi, 344001, China
Nanfang Hospital Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510515, China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210000, China
North China University of Science and Technology Affiliated Hospital
NOT_YET_RECRUITING

Tangshan, Hebei, 063000, China
Peking Union Medical College Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100005, China
The second Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITING

Kunming, Yunnan, 650101, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430022, China
Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410028, China

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