New antibody GEN1079 enters first human tests for advanced cancers

NCT ID NCT07387068

Recruiting now Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 05, 2026 · Updated 5 times

Summary

This early-stage trial is testing a new antibody called GEN1079 in people with certain advanced solid tumors. The study has three parts: first, finding a safe dose; then refining the dose; and finally, checking if the drug shrinks tumors. About 121 participants will receive the active drug, and the study lasts up to 67 weeks per person.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GEN1079 (an antibody)
What this could lead to: If this trial succeeds, it could point toward a new treatment option for certain advanced solid tumors.
What could go wrong: This is a very early Phase 1 trial, so the drug may not be safe or effective. It is small and only tests safety and dosing, not a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Centro Integral Oncologico Clara Campal
RECRUITING

Madrid, 28050, Spain
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Hospital HM Nou Delfos
RECRUITING

Barcelona, 8023, Spain
Hospital Quironsalud Barcelona
RECRUITING

Barcelona, 8023, Spain
Hospital Universitari Vall d'Hebron - VHIO
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario San Pedro
RECRUITING

Logroño, La Rioja, 26006, Spain
START Midwest, LLC
RECRUITING

Grand Rapids, Michigan, 49546, United States
START New York
RECRUITING

Lake Success, New York, 11042, United States
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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