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Scientists probe why walking costs more energy for child amputees

NCT ID NCT07076602

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers are studying how walking patterns relate to energy use in children aged 7 and older who have a one-sided lower limb amputation. Participants complete a 6-minute walking test with their prosthesis while wearing a portable device that measures oxygen consumption and heart rate. The study also tests whether a simpler measure called the Physiological Cost Index can reliably estimate energy use in this group. The goal is to help doctors and therapists better assess and plan rehabilitation for children with limb loss.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gait and energy expenditure assessment
What this could lead to
If the study links specific walking patterns to higher energy use, doctors could use that to guide rehabilitation and prosthetic adjustments for children with limb loss.
What could go wrong
This is a small observational study of 48 children, so it can only show associations, not cause and effect. The findings may not apply to all children with limb loss or to different types of prostheses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be drawn from the active caseload of pediatric patients with limb amputation who are currently under regular follow-up at the participating centers. These patients are monitored as part of routine clinical care. Only those meeting the predefined eligibility criteria (outlined elsewhere in the record) will be considered for inclusion. As such, the study population will reflect children and adolescents with limb amputation managed in specialized healthcare settings.

Ages

7 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Minor aged 7 and over * Congenital (transverse agenesis with break in limb continuity) or acquired (any etiology) unilateral transfemoral or transtibial amputation. \[In the case of femoral agenesis, the flexion axis of the prosthetic knee must coincide with the contralateral one to optimize the analysis of the kinematic parameters of gait\]. * Definitive prosthesis in place (no restriction on choice of prosthetic components) * Legal representatives not opposing participation in the study for the child Exclusion Criteria: * Revision surgery on the residual limb within the last 3 months * Progressive pathology associated with amputation (unstabilized sarcoma for example) which can strongly influence walking and/or energy expenditure * Cognitive and/or behavioral disorders that may affect compliance or test performance * Patient already included in an interventional research protocol that could lead to bias in the present study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation of lower extremity, all causes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre 01 - CHU de RENNES, Hôpital Pontchaillou

    RECRUITING

    Rennes, France

  • Centre 02 - CHU Brest, Hôpital Morvan

    RECRUITING

    Brest, France

  • Centre 03 - CHU Dijon, Hôpital Le Bocage

    RECRUITING

    Dijon, France

  • Centre 04 - Hospices Civils de Lyon, Hôpital Mère Enfant Groupement Hospitalier Est

    RECRUITING

    Bron, France

  • Centre 06 - Institut Robert Merle d'Aubigné, IRMA Valenton

    NOT_YET_RECRUITING

    Valenton, 94460, France

  • Centre 08 - Croix-Rouge Française, Centre Médico-Chirurgical de Réadaptation des Massues

    NOT_YET_RECRUITING

    Lyon, 69322, France

  • Fondation Hopale, Centre Jacques Calvé

    NOT_YET_RECRUITING

    Berck, 62600, France

  • Hôpitaux Paris Est Val-de-Marne, Hôpital Saint-Maurice

    RECRUITING

    Saint-Maurice, France