New drug FWY003 aims to halt blinding eye disease

NCT ID NCT07441642

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This Phase 2 trial tests FWY003, an experimental drug, in 272 people with geographic atrophy (a form of advanced age-related macular degeneration). The goal is to see if different doses can slow the growth of damaged areas in the eye and preserve vision. Participants receive either FWY003 or a placebo by injection, and researchers will monitor safety and changes in eyesight over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FWY003
What this could lead to: If successful, this could lead to a treatment that slows vision loss from geographic atrophy, helping people with age-related macular degeneration maintain sight longer.
What could go wrong: This is an early Phase 2 trial with only 272 participants, so results may not confirm effectiveness. The drug may not slow disease progression or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION

Contacts and locations

Locations

Advanced Research LLC
RECRUITING

Boynton Beach, Florida, 33437, United States
Advanced Research LLC
RECRUITING

Deerfield Beach, Florida, 33064, United States
California Retina Consultants
RECRUITING

Santa Barbara, California, 93103, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Emanuelli Research and Development Center LLC
RECRUITING

Arecibo, 00612, Puerto Rico
Erie Retina Research LLC
RECRUITING

Erie, Pennsylvania, 16505, United States
Mid Atlantic Retina
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
NJ Retina
RECRUITING

Toms River, New Jersey, 08755, United States
New York Eye and Ear Infirmary of Mount Sinai
RECRUITING

New York, New York, 10003, United States
Novartis Investigative Site
RECRUITING

Albury, New South Wales, 2640, Australia
Novartis Investigative Site
RECRUITING

Parramatta, New South Wales, 2150, Australia
Novartis Investigative Site
RECRUITING

Strathfield, New South Wales, 2135, Australia
Novartis Investigative Site
RECRUITING

East Melbourne, Victoria, 3002, Australia
Novartis Investigative Site
RECRUITING

Sofia, 1618, Bulgaria
Novartis Investigative Site
RECRUITING

London, Ontario, N6A 4L8, Canada
Novartis Investigative Site
RECRUITING

Ottawa, Ontario, K2B 7E9, Canada
Novartis Investigative Site
RECRUITING

Prague, 100 34, Czechia
Novartis Investigative Site
RECRUITING

Prague, 128 08, Czechia
Novartis Investigative Site
RECRUITING

Lyon, Rhone, 69004, France
Novartis Investigative Site
RECRUITING

Créteil, 94000, France
Novartis Investigative Site
RECRUITING

Dijon, 21000, France
Novartis Investigative Site
RECRUITING

Paris, 75940, France
Novartis Investigative Site
RECRUITING

Bonn, 53105, Germany
Novartis Investigative Site
RECRUITING

Ludwigshafen, 67063, Germany
Novartis Investigative Site
RECRUITING

Münster, 48145, Germany
Novartis Investigative Site
RECRUITING

Tübingen, 72076, Germany
Novartis Investigative Site
RECRUITING

Pécs, Baranya, 7621, Hungary
Novartis Investigative Site
RECRUITING

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site
RECRUITING

Budapest, H-1083, Hungary
Novartis Investigative Site
RECRUITING

Florence, FI, 50134, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20122, Italy
Novartis Investigative Site
RECRUITING

Milan, MI, 20132, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00184, Italy
Novartis Investigative Site
RECRUITING

Bunkyo Ku, Tokyo, 113-8655, Japan
Novartis Investigative Site
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-631, Poland
Novartis Investigative Site
RECRUITING

Krakow, 31-070, Poland
Novartis Investigative Site
RECRUITING

Cluj-Napoca, Cluj, 400006, Romania
Novartis Investigative Site
RECRUITING

Bucharest, 011658, Romania
Novartis Investigative Site
RECRUITING

Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site
RECRUITING

Sant Cugat Del V, Barcelona, 08190, Spain
Novartis Investigative Site
RECRUITING

Burjassot, Valencia, 46100, Spain
Novartis Investigative Site
RECRUITING

Córdoba, 14012, Spain
Novartis Investigative Site
RECRUITING

Bristol, BS1 2LX, United Kingdom
Novartis Investigative Site
RECRUITING

London, NW10 7NS, United Kingdom
Opthamalic Consultants of Boston
RECRUITING

Boston, Massachusetts, 02114, United States
Retina Consultants TX Rsrch Ctr
RECRUITING

Bellaire, Texas, 77401, United States
Retina Consultants of Houston PA
RECRUITING

Houston, Texas, 77030, United States
Retina Consultants of Texas
RECRUITING

Katy, Texas, 77494, United States
Retina Vitreous Associates of Florida
RECRUITING

St. Petersburg, Florida, 33711, United States
Retinal Consultants Medical Group Inc
RECRUITING

Sacramento, California, 95841, United States
Salehi Retina Institute
RECRUITING

Huntington Beach, California, 92647, United States

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