New combo aims to outsmart recurrent breast cancer in phase 2 trial

NCT ID NCT06849947

First seen Jan 09, 2026 · Last updated May 11, 2026 · Updated 20 times

Summary

This study tests whether a combination of fulvestrant and ribociclib works better than standard treatments for people with a certain type of advanced breast cancer (HR+, HER2-) that came back after they finished a previous targeted therapy. About 272 adults will be randomly assigned to receive either the two-drug combo or their doctor's choice of treatment. The main goal is to see how long the cancer stays under control, while also tracking side effects and overall survival.

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