New combo therapy offers hope for Tough-to-Treat gout
NCT ID NCT04762498
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 26 times
Summary
This study tested a gout medication called pegloticase (KRYSTEXXA) given every 4 weeks along with weekly methotrexate in 50 adults with chronic gout that did not respond to standard treatments. The goal was to see if this combination could lower uric acid levels and be safe. Results help determine the best dose for future studies.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for UNCONTROLLED GOUT are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Altoona Center for Clinical Research
Duncansville, Pennsylvania, 16635, United States
-
Arizona Arthritis & Rheumatology Research, PLLC
Glendale, Arizona, 85306, United States
-
Arthritis Clinic: Western Washington Medical Group
Bothell, Washington, 98021, United States
-
Arthritis Northwest PLLC
Spokane, Washington, 99204, United States
-
Biopharma Informatic, LLC
Houston, Texas, 77043, United States
-
East Bay Rheumatology Medical Group, Inc.
San Leandro, California, 94578, United States
-
GCP Clinical Research
Tampa, Florida, 33064, United States
-
Napa Research Center
Pompano Beach, Florida, 33064, United States
-
Orthopedic Physicians Alaska
Anchorage, Alaska, 99508, United States
-
ProHealth Research Center
Doral, Florida, 33166, United States
-
Shelby Clinical Research, LLC
Shelby, North Carolina, 28150, United States
-
The Center for Rheumatology and Bone Research
Wheaton, Maryland, 20902, United States
Conditions
Explore the condition pages connected to this study.