Antidepressant repurposed in fight against brain cancer
NCT ID NCT05634707
Summary
This early-stage study is testing if a common antidepressant drug, fluoxetine (Prozac), can make a standard chemotherapy drug (temozolomide) more effective at killing recurrent brain tumor cells. The researchers want to see if fluoxetine causes stress inside cancer cells, making them more vulnerable. A small group of adults with a returning brain tumor (glioma) who are scheduled for surgery will take the drugs for a short period before their operation so the tumor tissue can be analyzed.
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Contacts and locations
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Locations
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NYU Langone Health
New York, New York, 10016, United States
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Stanford Cancer Institute
Stanford, California, 94305, United States
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The Preston Robert Tisch Brain Tumor Center at Duke University
Durham, North Carolina, 27710, United States
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UC San Diego Moores Cancer Center
San Diego, California, 90074-1539, United States
Conditions
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