Could an antidepressant boost brain tumor treatment?
NCT ID NCT05634707
First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 20 times
Summary
This study tests whether fluoxetine, an FDA-approved antidepressant, can make chemotherapy more effective for people with a recurrent type of brain tumor called IDHwt glioma. Ten participants will receive either fluoxetine or no additional drug before surgery, and researchers will measure changes in tumor cells. The goal is to see if fluoxetine can stress the tumor cells' lysosomes, potentially improving how well the chemotherapy drug temozolomide kills them.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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NYU Langone Health
New York, New York, 10016, United States
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Stanford Cancer Institute
Stanford, California, 94305, United States
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The Preston Robert Tisch Brain Tumor Center at Duke University
Durham, North Carolina, 27710, United States
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UC San Diego Moores Cancer Center
San Diego, California, 90074-1539, United States
Conditions
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