New hope for frail myeloma patients: shorter drug combo trial launches

NCT ID NCT07107529

Recruiting now Disease control Sponsor: European Myeloma Network B.V. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two drug combinations (teclistamab plus daratumumab or talquetamab plus daratumumab) in 150 frail patients newly diagnosed with multiple myeloma. The goal is to see if these fixed-duration treatments can control the cancer for at least 18 months. Participants receive injections under the skin and are monitored for side effects and disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Teclistamab, talquetamab, and daratumumab (drugs given as injections under the skin)
What this could lead to: If successful, this could offer a fixed-duration treatment option that controls multiple myeloma in frail patients who are often too weak for standard therapies.
What could go wrong: This is a Phase 2 trial with only 150 participants, so results are preliminary. The drugs may cause side effects like infections or allergic reactions, and the treatment may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA (MM)

Contacts and locations

Locations

ES-Barcelona-H.U. Vall d'Hebrón [06-002]
NOT_YET_RECRUITING

Barcelona, Spain
ES-Las Palmas-H.U. de Gran Canaria Dr Negrín [06-030]
NOT_YET_RECRUITING

Las Palmas, Spain
ES-Murcia-H.U. Virgen de la Arrixaca [06-016]
RECRUITING

Murcia, Spain
ES-Salamanca-H.U. de Salamanca [06-021]
NOT_YET_RECRUITING

Salamanca, Spain
IT-Ascoli Piceno-Ospedale Mazzoni [01-016]
RECRUITING

Ascoli Piceno, Italy
IT-Bari-A.O.U. Consorziale Policlinico - Medicina Interna [01-018]
NOT_YET_RECRUITING

Bari, Italy
IT-Bergamo-A.O. Papa Giovanni XXIII [01-003]
NOT_YET_RECRUITING

Bergamo, Italy
IT-Bologna-A.O.U. di Bologna - Policlinico S. Orsola Malpighi [01-004]
NOT_YET_RECRUITING

Bologna, Italy
IT-Bolzano-Ospedale di Bolzano - Azienda Sanitaria dell'Alto Adige [01-021]
NOT_YET_RECRUITING

Bolzano, Italy
IT-Como-Ospedale Classificato Valduce [01-104]
RECRUITING

Como, Italy
IT-Milano-Fondazione IRCCS Ca' Grande Ospedale Maggiore Policlinico [01-039]
NOT_YET_RECRUITING

Milan, Italy
IT-Milano-Ospedale S. Carlo Borromeo [01-105]
RECRUITING

Milan, Italy
IT-Novara-A.O.U. Maggiore della Carità [01-010]
RECRUITING

Novara, Italy
IT-Pescara-Azienda USL di Pescara P.O. dello Spirito Santo [01-053]
RECRUITING

Pescara, Italy
IT-Roma-ASL Roma 1 [01-101]
NOT_YET_RECRUITING

Roma, Italy
IT-Roma-Policlinico Umberto I - Università 'Sapienza' [01-013]
NOT_YET_RECRUITING

Roma, Italy
IT-Torino-A.O.U. Città della Salute e della Scienza di Torino-SSD Clinical trials [01-001]
NOT_YET_RECRUITING

Torino, Italy
IT-Varese-Ospedale di Circolo [01-111]
NOT_YET_RECRUITING

Varese, Italy
NL-Amsterdam-Vrije Universiteit Medical Center (VUMC) [02-007]
NOT_YET_RECRUITING

Amsterdam, Netherlands
NL-Arnhem-Rijnstate Hospital [02-009]
NOT_YET_RECRUITING

Arnhem, Netherlands
NL-Den Haag-Haga Ziekenhuis [02-016]
NOT_YET_RECRUITING

The Hague, Netherlands
NL-Enschede-Medisch Spectrum Twente [02-024]
NOT_YET_RECRUITING

Enschede, Netherlands
NL-Groningen-University Medical Center Groningen [02-030]
NOT_YET_RECRUITING

Groningen, Netherlands
NL-Nieuwegein-S. Antonius Hospital [02-038]
NOT_YET_RECRUITING

Nieuwegein, Netherlands
NL-Schiedam-Franciscus Vlietland Hospital [02-049]
NOT_YET_RECRUITING

Schiedam, Netherlands
NL-Sittard-Geleen-Zuyderland Medical Center [02-058]
NOT_YET_RECRUITING

Sittard, Netherlands
NL-Zwolle-Isala Klinieken [02-057]
NOT_YET_RECRUITING

Zwolle, Netherlands
NO-Oslo-Oslo University Hospital [23-007]
NOT_YET_RECRUITING

Oslo, Norway
NO-Tønsberg-Vestfold Hospital Trust [23-012]
NOT_YET_RECRUITING

Tønsberg, Norway

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