New hope for frail myeloma patients: shorter drug combo trial launches
NCT ID NCT07107529
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two drug combinations (teclistamab plus daratumumab or talquetamab plus daratumumab) in 150 frail patients newly diagnosed with multiple myeloma. The goal is to see if these fixed-duration treatments can control the cancer for at least 18 months. Participants receive injections under the skin and are monitored for side effects and disease progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Teclistamab, talquetamab, and daratumumab (drugs given as injections under the skin)
What this could lead to
If successful, this could offer a fixed-duration treatment option that controls multiple myeloma in frail patients who are often too weak for standard therapies.
What could go wrong
This is a Phase 2 trial with only 150 participants, so results are preliminary. The drugs may cause side effects like infections or allergic reactions, and the treatment may not work for everyone.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MULTIPLE MYELOMA (MM) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
ES-Barcelona-H.U. Vall d'Hebrón [06-002]
NOT_YET_RECRUITINGBarcelona, Spain
-
ES-Las Palmas-H.U. de Gran Canaria Dr Negrín [06-030]
NOT_YET_RECRUITINGLas Palmas, Spain
-
ES-Murcia-H.U. Virgen de la Arrixaca [06-016]
RECRUITINGMurcia, Spain
-
ES-Salamanca-H.U. de Salamanca [06-021]
NOT_YET_RECRUITINGSalamanca, Spain
-
IT-Ascoli Piceno-Ospedale Mazzoni [01-016]
RECRUITINGAscoli Piceno, Italy
-
IT-Bari-A.O.U. Consorziale Policlinico - Medicina Interna [01-018]
NOT_YET_RECRUITINGBari, Italy
-
IT-Bergamo-A.O. Papa Giovanni XXIII [01-003]
NOT_YET_RECRUITINGBergamo, Italy
-
IT-Bologna-A.O.U. di Bologna - Policlinico S. Orsola Malpighi [01-004]
NOT_YET_RECRUITINGBologna, Italy
-
IT-Bolzano-Ospedale di Bolzano - Azienda Sanitaria dell'Alto Adige [01-021]
NOT_YET_RECRUITINGBolzano, Italy
-
IT-Como-Ospedale Classificato Valduce [01-104]
RECRUITINGComo, Italy
-
IT-Milano-Fondazione IRCCS Ca' Grande Ospedale Maggiore Policlinico [01-039]
NOT_YET_RECRUITINGMilan, Italy
-
IT-Milano-Ospedale S. Carlo Borromeo [01-105]
RECRUITINGMilan, Italy
-
IT-Novara-A.O.U. Maggiore della Carità [01-010]
RECRUITINGNovara, Italy
-
IT-Pescara-Azienda USL di Pescara P.O. dello Spirito Santo [01-053]
RECRUITINGPescara, Italy
-
IT-Roma-ASL Roma 1 [01-101]
NOT_YET_RECRUITINGRoma, Italy
-
IT-Roma-Policlinico Umberto I - Università 'Sapienza' [01-013]
NOT_YET_RECRUITINGRoma, Italy
-
IT-Torino-A.O.U. Città della Salute e della Scienza di Torino-SSD Clinical trials [01-001]
NOT_YET_RECRUITINGTorino, Italy
-
IT-Varese-Ospedale di Circolo [01-111]
NOT_YET_RECRUITINGVarese, Italy
-
NL-Amsterdam-Vrije Universiteit Medical Center (VUMC) [02-007]
NOT_YET_RECRUITINGAmsterdam, Netherlands
-
NL-Arnhem-Rijnstate Hospital [02-009]
NOT_YET_RECRUITINGArnhem, Netherlands
-
NL-Den Haag-Haga Ziekenhuis [02-016]
NOT_YET_RECRUITINGThe Hague, Netherlands
-
NL-Enschede-Medisch Spectrum Twente [02-024]
NOT_YET_RECRUITINGEnschede, Netherlands
-
NL-Groningen-University Medical Center Groningen [02-030]
NOT_YET_RECRUITINGGroningen, Netherlands
-
NL-Nieuwegein-S. Antonius Hospital [02-038]
NOT_YET_RECRUITINGNieuwegein, Netherlands
-
NL-Schiedam-Franciscus Vlietland Hospital [02-049]
NOT_YET_RECRUITINGSchiedam, Netherlands
-
NL-Sittard-Geleen-Zuyderland Medical Center [02-058]
NOT_YET_RECRUITINGSittard, Netherlands
-
NL-Zwolle-Isala Klinieken [02-057]
NOT_YET_RECRUITINGZwolle, Netherlands
-
NO-Oslo-Oslo University Hospital [23-007]
NOT_YET_RECRUITINGOslo, Norway
-
NO-Tønsberg-Vestfold Hospital Trust [23-012]
NOT_YET_RECRUITINGTønsberg, Norway