Breakthrough eye injection shows promise in slowing blinding disease

NCT ID NCT04435366

Summary

This study tested whether a monthly injection into the eye, called avacincaptad pegol (Zimura), could safely slow the progression of geographic atrophy. Geographic atrophy is a severe form of age-related macular degeneration that causes permanent, progressive vision loss. The trial involved 448 patients who were randomly assigned to receive either the real injection or a sham (pretend) procedure to compare results.

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Contacts and locations

Locations

  • A.O.U. Policlinico Sant'Orsola-Malpighi

    Bologna, 40138, Italy

  • AOU Universita degli Studi della Campania Luigi Vanvitelli UOC Oculistica

    Naples, 80131, Italy

  • Associated Retinal Consultants, P.C.

    Royal Oak, Michigan, 48073, United States

  • Associates in Ophthalmology, Ltd

    West Mifflin, Pennsylvania, 15122, United States

  • Augenklinik University Hospital Cologne

    Cologne, 50937, Germany

  • Augenzentrum am St. Franziskus-Hospital

    Münster, 48145, Germany

  • Austin Retina Associates

    Austin, Texas, 78705, United States

  • Axon Clinical s.r.o.

    Prague, Smichov, 150 00, Czechia

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134, Italy

  • Azienda Ospedaliera di Padova Unità Operativa Complessa di Clinica Oculistica

    Padua, 35128, Italy

  • Azienda Sanitaria Universitaria Integrata

    Udine, 33100, Italy

  • Bajcsy Zsilinszky Kórház - Szemészet

    Budapest, 1106, Hungary

  • Barzilai Medical Center

    Ashkelon, 7830604, Israel

  • Black Hills Regional Eye Institute

    Rapid City, South Dakota, 57701, United States

  • Budapest Retina Associates

    Budapest, 1133, Hungary

  • Buenos Aires Macula S.A.

    Buenos Aires, Buenos Aires F.D., Cl061AAE, Argentina

  • CHU Bocage

    Dijon, 21079, France

  • CHU Brugmann

    Brussels, Belgium

  • CHU de Bordeaux - Hopital Pellegrin

    Bordeaux, 33000, France

  • CHU de Nantes

    Nantes, 44043, France

  • Calgary Retina Consultants

    Calgary, Alberta, T2H 0C8, Canada

  • California Retina Consultants

    Oxnard, California, 93036, United States

  • Caminomed

    Tarnowskie Góry, 42-600, Poland

  • Canadian Centre for Advanced Eye Therapeutics Inc.

    Mississauga, Ontario, L4W 1W9, Canada

  • Carmel Medical Center

    Haifa, 3436212, Israel

  • Carolina Macula and Retina

    Mt. Pleasant, South Carolina, 29464, United States

  • Casey Eye Institute

    Portland, Oregon, 97239, United States

  • Center for Retina and Macula Disease

    Winter Haven, Florida, 33880, United States

  • Centre Ophtalmologique d'Imagerie et de Laser

    Paris, 75015, France

  • Centre Paradis Monticelli

    Marseille, 13008, France

  • Centre Pole Vision Val d'Ouest

    Écully, 69130, France

  • Centre St Exupery

    Saint-Cyr-sur-Loire, 37540, France

  • Centre d'exploration ophtalmologique de l'Odeon

    Paris, 75006, France

  • Centre d'ophtalmologie Rabelais

    Lyon, 69002, France

  • Centro Medico Micro Diagnostico y Microcirugla Ocular

    Rosario, S2000TC, Argentina

  • Centro Médico Grupo Laser Visión

    Rosario, Santa Fe Province, CP2000, Argentina

  • Centro Oftalmológico Dr. Charles SA

    Buenos Aires, Buenos Aires F.D., C1116ABA, Argentina

  • Centro Privado de Oftalmologia - OFTAR Mendoza SRL

    Mendoza, M5500GGK, Argentina

  • Centro Privado de Ojos Romagosa S.A.

    Córdoba, X5000AAJ, Argentina

  • Centro de Diagnóstico y Cirugía Ocular "Oftalmólogos Especialistas"

    Rosario, Santa Fe Province, S2000ANJ, Argentina

  • Centro de Ensino e Pesquisa do Instituto da Visao (CEPIV)

    Belo Horizonte, 30330, Brazil

  • Charleston Neuroscience Institute

    Ladson, South Carolina, 29456, United States

  • Cincinnati Eye Institute

    Cincinnati, Ohio, 45242, United States

  • Clinic Rechts der Isar

    Munich, 81675, Germany

  • Clinica De Oftalmologia Sandiego

    Medellín, Antioquia, 050016, Colombia

  • Clinica Universidad de Navarra

    Pamplona, 31008, Spain

  • Clinica de Oftalmologia Barraquer

    Barcelona, 08021, Spain

  • Clinical hospital Center Osijek

    Osijek, 31000, Croatia

  • Colorado Retina Associates

    Lakewood, Colorado, 80228, United States

  • Connecticut Eye Consultants, P.C.

    Danbury, Connecticut, 06810, United States

  • Cumberland Valley Retina Consultants

    Hagerstown, Maryland, 21740, United States

  • Debrecen University Clinical Center, Dept of Ophthalmology

    Debrecen, H-4032, Hungary

  • Department of Ophthalmology, Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Doheny Eye Center, UCLA

    Pasadena, California, 91105, United States

  • Dr Kai Noor Silmakabinet

    Tallinn, 11412, Estonia

  • East Florida Eye Institute

    Stuart, Florida, 34994, United States

  • Edith Wolfson Medical Center

    Holon, 5822012, Israel

  • Eye Medical Center of Fresno

    Fresno, California, 93720, United States

  • EyeHealth Northwest

    Portland, Oregon, 97225, United States

  • Florida Eye Associates

    Melbourne, Florida, 32901, United States

  • Florida Eye Clinic

    Altamonte Springs, Florida, 32701, United States

  • Fondation Alolphe de Rotschild

    Paris, 75019, France

  • Fondazione GB Bietti IRCCS

    Roma, 00198, Italy

  • Fondazione PTV

    Roma, 00133, Italy

  • Fundacion OJlalmologica Nacional - FUNDONAL

    Bogotá, 110311, Colombia

  • Ganglion Medical Center

    Pécs, H-7621, Hungary

  • Georgia Retina, P.C.

    Marietta, Georgia, 30060, United States

  • H.U. Puerta de Hierro-Majadahonda

    Majadahonda, 28222, Spain

  • Hadassah University Hospital

    Jerusalem, 91120, Israel

  • Hanush Hospital

    Vienna, 1140, Austria

  • Hopital Intercommunal

    Créteil, 94010, France

  • Hopital de la Croix Rousse

    Lyon, 69004, France

  • Hospital Clínico Universitario "Lozano Blesa"

    Zaragoza, 50009, Spain

  • Hospital La Arruzafa

    Córdoba, CP 14012, Spain

  • Hospital Sao Paulo - UNIFESP

    Vila Clementino, 04023-062, Brazil

  • Hull University Teaching Hospitals NHS Trust

    Hull, HU3 2JZ, United Kingdom

  • Hungarian Military Hospital Center

    Budapest, 1068, Hungary

  • Hôpital Lariboisière

    Paris, 75010, France

  • IMED Servicio Oftalmología

    Valencia, 46100, Spain

  • IPEPO - Instituto da visão

    São Paulo, 04038-032, Brazil

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Illinois Eye Center

    Peoria, Illinois, 61615, United States

  • Institut Catala de Retina

    Barcelona, 08022, Spain

  • Institut de la Macula

    Barcelona, 08022, Spain

  • Instituto Clinico Quirurgico de Oftalmologia

    Bilbao, 48010, Spain

  • Instituto Oftalmologico Gomez-Ulla

    Santiago de Compostela, 15706, Spain

  • Instituto Oftalmológico de Buenos Aires

    Buenos Aires, C1120AAN, Argentina

  • Instituto Oftalmológico de Córdoba

    Córdoba, X5000III, Argentina

  • Jules Stein Eye Institute/David Geffen School of Medicine

    Los Angeles, California, 90095, United States

  • Kaplan Medical Center

    Rehovot, 76100, Israel

  • Klinika Okulistyczna OFT ALMIKA Sp. z o. o.

    Bydgoszcz, 85-631, Poland

  • Long Island Vitreoretinal Consultant

    Great Neck, New York, 11021, United States

  • Ludwig-Maximilians-University Munich

    Munich, 80336, Germany

  • Medical Center Julianów

    Lodz, 91-485, Poland

  • Medical Center Ophthalmology Associates

    San Antonio, Texas, 78240, United States

  • Medical University of Vienna

    Vienna, 1090, Austria

  • Medizinische Universitaet Graz - Augenklinik

    Graz, 8036, Austria

  • Medizinische Universitaet Innsbruck - Universitaetsklinik fuer Augenheilkunde und Optometrie

    Innsbruck, 6020, Austria

  • Mid Atlantic Retina

    Philadelphia, Pennsylvania, 19107, United States

  • Midwest Eye Institute

    Indianapolis, Indiana, 46290, United States

  • National Ophthalmic Research Institute

    Fort Myers, Florida, 33912, United States

  • Northern California Retina Vitreous Associates

    Mountain View, California, 94040, United States

  • Nuovo Arcispedale Sant' Anna (A.O.U. di Ferrara)

    Ferrara, 44124, Italy

  • OCLI

    Oceanside, New York, 11572, United States

  • Ochsner Medical Center

    New Orleans, Louisiana, 70121, United States

  • Ophthalmic Consultants of Boston

    Boston, Massachusetts, 02114, United States

  • Ophthalmic Consultants of the Capital Region

    Troy, New York, 12180, United States

  • Orange County Retinal Medical Group

    Santa Ana, California, 92705, United States

  • Ospedale Clinicizzato Universita di Chieti "Ss Annunziata"

    Chieti, 66100, Italy

  • Ospedale Luigi Sacco

    Milan, 20157, Italy

  • Ospedale Maggiore Policlinico Milano

    Milan, 20122, Italy

  • Ospedali Riuniti di Ancona

    Ancona, 60126, Italy

  • Pacific Northwest Retina

    Bellevue, Washington, 98004, United States

  • Palmetto Retina Center

    West Columbia, South Carolina, 29169, United States

  • Pauls Stradinis Clinical University Hospital

    Riga, LV-1002, Latvia

  • RWTH Aachen University

    Aachen, 52074, Germany

  • Rambam Medical Centre

    Haifa, 3109601, Israel

  • Rand Eye Institute

    Deerfield Beach, Florida, 33064, United States

  • Retina Associates of Sarasota

    Sarasota, Florida, 34233, United States

  • Retina Associates of Western NY, PC

    Rochester, New York, 14620, United States

  • Retina Associates, LLC

    Lenexa, Kansas, 66215, United States

  • Retina Care Specialists

    Palm Beach Gardens, Florida, 33410, United States

  • Retina Center

    Minneapolis, Minnesota, 55404, United States

  • Retina Center NW, PLLC

    Silverdale, Washington, 98383, United States

  • Retina Center of New Jersey, LLC

    Bloomfield, New Jersey, 07003, United States

  • Retina Center of Texas

    Southlake, Texas, 76092, United States

  • Retina Centre of Ottawa

    Ottawa, K2B 7E9, Canada

  • Retina Consultants of Hawaii, Inc

    ‘Aiea, Hawaii, 96701, United States

  • Retina Consultants of Nevada

    Henderson, Nevada, 89052, United States

  • Retina Consultants of Orange County

    Fullerton, California, 92835, United States

  • Retina Consultants of Southern California

    Redlands, California, 92374, United States

  • Retina Consultants of Southern Colorado, P.C.

    Colorado Springs, Colorado, 80909, United States

  • Retina Foundation of the Southwest

    Dallas, Texas, 75231, United States

  • Retina Group of Florida

    Fort Lauderdale, Florida, 33308, United States

  • Retina Group of New England, PC

    Waterford, Connecticut, 06385, United States

  • Retina Health Center

    Fort Myers, Florida, 33907, United States

  • Retina Institute of Virginia

    Richmond, Virginia, 23235, United States

  • Retina Northwest, PC

    Portland, Oregon, 97221, United States

  • Retina Research Institute at New England Retinal Consultants

    Springfield, Massachusetts, 01107, United States

  • Retina Research Institute of Texas

    Abilene, Texas, 79606, United States

  • Retina Research of Beaufort, LLC

    Beaufort, South Carolina, 29902, United States

  • Retina Specialty Institute

    Pensacola, Florida, 32503, United States

  • Retina Vitreous Associates of Florida

    St. Petersburg, Florida, 33711, United States

  • Retina Vitreous Surgeons of Central New York, PC

    Liverpool, New York, 13088, United States

  • Retina and Vitreous Center of Southern Oregon

    Ashland, Oregon, 97520, United States

  • Retina and Vitreous of Texas, PLLC

    Houston, Texas, 77025, United States

  • Retina-Vitreous Associates Medical Group

    Beverly Hills, California, 90211, United States

  • Retinal Associates of Utah

    Salt Lake City, Utah, 84107, United States

  • Retinal Consultants Medical Group, Inc.

    Sacramento, California, 95825, United States

  • Retinal Consultants of Houston

    The Woodlands, Texas, 77384, United States

  • Retinal Diagnostic Center

    Campbell, California, 95008, United States

  • Rio Hortega University Hospital

    Valladolid, 47012, Spain

  • Rocky Mountain Retina Consultants

    Salt Lake City, Utah, 84107, United States

  • Royal Victorian Eye & Ear Hospital

    East Melbourne, 3002, Australia

  • Scheie Eye Institute, University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Semmelweis University, Dept of Ophthalmology

    Budapest, H-1085, Hungary

  • Shamir Medical Center

    Be’er Ya‘aqov, 70300, Israel

  • Sierra Eye Associates

    Reno, Nevada, 89502, United States

  • Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Southeast Retina Center

    Augusta, Georgia, 30909, United States

  • Southeastern Retina Associates, PC

    Johnson City, Tennessee, 37604, United States

  • Southeastern Retina Associates, PC

    Knoxville, Tennessee, 37922, United States

  • Southern California Desert Retina Consultants

    Palm Desert, California, 92211, United States

  • Southern Vitreoretinal Associates, PL

    Tallahassee, Florida, 32308, United States

  • Southwest Retina Specialists

    Amarillo, Texas, 79106, United States

  • St. Louis University

    St Louis, Missouri, 63110, United States

  • St.Joseph's Health Care London

    London, Ontario, N6A4V2, Canada

  • Strategic Clinical Research Group

    Willow Park, Texas, 76087, United States

  • Sydney Eye Hospital

    Sydney, New South Wales, 2000, Australia

  • Sydney Retina Clinic and Day Surgery

    Sydney, New South Wales, 2000, Australia

  • Szabolcs-Szatmar-Bereg County Hospital and University Teaching Hospital

    Nyíregyháza, 4400, Hungary

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

    Szeged, H-6720, Hungary

  • Tartu University Hospital

    Tartu, 50406, Estonia

  • The Retina Care Center

    Baltimore, Maryland, 21209, United States

  • The Retina Group of Washington

    Chevy Chase, Maryland, 20815, United States

  • UBC/VGH Eye Care Center

    Vancouver, British Columbia, V5Z3N9, Canada

  • UMASS Memorial Eye Center

    Worcester, Massachusetts, 01605, United States

  • University Eye Hospital, MHH

    Hanover, 30625, Germany

  • University Health Network

    Toronto, Ontario, M5T 2S8, Canada

  • University Retina and Macula Associates, PC

    Lemont, Illinois, 60439, United States

  • University clinic Leipzig AÖR

    Leipzig, 04103, Germany

  • University of Bonn

    Bonn, Germany

  • University of California, San Diego

    La Jolla, California, 92093, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Göttingen

    Göttingen, 37075, Germany

  • University of Miami-Bascom Palmer Eye Institute

    Miami, Florida, 33136, United States

  • University of Ottawa Eye Institute

    Ottawa, Ontario, K1H8L6, Canada

  • University of Pisa

    Pisa, 56126, Italy

  • University of Utah, John A. Moran Eye Center

    Salt Lake City, Utah, 84132, United States

  • Universitäts-Augenklinik

    Tübingen, 72076, Germany

  • Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde Studienzentrum

    Hamburg, 20251, Germany

  • Universitätsklinikum Münster

    Münster, 48149, Germany

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, 23538, Germany

  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Mainz, 55131, Germany

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego

    Wroclaw, 50-556, Poland

  • VOR - Hospital General de Catalunya

    Barcelona, 08195, Spain

  • Valley Retina Institute

    McAllen, Texas, 78503, United States

  • Vistar Eye Center

    Roanoke, Virginia, 24018, United States

  • Vitreo Retinal Consultants & Surgeons

    Wichita, Kansas, 67214, United States

  • VitreoRetinal Associates, P.A.

    Gainesville, Florida, 32607, United States

  • Vitreoretinal Associates, PC

    Worcester, Massachusetts, 01605, United States

  • Vitreous Retina Macula Consultants of New York (VRMNY)

    New York, New York, 10022, United States

  • Wagner Macular & Retina Center

    Norfolk, Virginia, 23502, United States

  • Western Carolina Retinal Associates

    Asheville, North Carolina, 28803, United States

  • Wolfe Eye Clinic

    West Des Moines, Iowa, 50266, United States

Conditions

Explore the condition pages connected to this study.