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Gene therapy shot for dry AMD shows promise in early trial

NCT ID NCT04437368

Terminated Disease control Sponsor: Gyroscope Therapeutics Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single injection of a gene therapy called GT005 in 98 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. The goal was to see if the treatment could slow the growth of damaged areas in the eye and check for side effects. The trial was stopped early, so results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration dry age related macular degeneration eye disorder Geographic Atrophy primary anetoderma retinal degeneration retinal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY AGE-RELATED MACULAR DEGENERATION

Contacts and locations

Locations

  • Austin Research Center for Retina, PLLC

    Austin, Texas, 78705, United States

  • Bascom Palmer Eye Institute

    Miami, Florida, 33136, United States

  • Bristol Eye Hospital

    Bristol, BS1 2LX, United Kingdom

  • Byers Eye Institute at Stanford

    Palo Alto, California, 94303, United States

  • CHU Hôpital F. Mitterrand

    Dijon, Bourgogne-Franche-Comté, 21079, France

  • CHU de Nantes - Hôtel-Dieu

    Nantes, Pays de la Loire Region, 44000, France

  • Casey Eye Institute

    Portland, Oregon, 97239, United States

  • Centre Paradis Monticelli

    Marseille, Alpes-Cote d'Azur, 13008, France

  • Charles Retina Institute

    Memphis, Tennessee, 38138, United States

  • Cincinnati Eye Institute

    Cincinnati, Ohio, 45242, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Baviera

    Madrid, 28046, Spain

  • Clinica Oftalvist Valencia

    Valencia, 46100, Spain

  • Clinica Universidad de Navarra - Pamplona

    Pamplona, Navarre, 31008, Spain

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Department of Ophthalmology UW Medicine

    Seattle, Washington, 98104-2499, United States

  • Erie Retinal Surgery, INC

    Erie, Pennsylvania, 16507, United States

  • Hospital La Arruzafa

    Córdoba, 14012, Spain

  • Hospital Universitari General de Catalunya

    Sant Cugat del Vallès, Barcelona, 08195, Spain

  • Internationale Innovative Ophthalmochirurgie

    Düsseldorf, 40549, Germany

  • Mid Atlantic Retina

    Philadelphia, Pennsylvania, 19107, United States

  • Midwest Eye Institute Northside

    Indianapolis, Indiana, 46290, United States

  • Moorfields Eye Hospital - NHS Foundation Trust

    London, EC1V 2PD, United Kingdom

  • Oftalmika Spolka z ograniczona odpowiedzialnoscia

    Bydgoszcz, 85-631, Poland

  • Ophthalmic Consultants of Boston (OCB)

    Boston, Massachusetts, 02114, United States

  • Oregon Retina

    Eugene, Oregon, 97401, United States

  • Retina Associates of Southern California

    Huntington Beach, California, 92647, United States

  • Retina Associates of Western New York

    Rochester, New York, 14620, United States

  • Retina Consultants San Diego

    Poway, California, 92064, United States

  • Retina Consultants of Houston-TMC

    Bellaire, Texas, 77401, United States

  • Retina Vitreous Associates of Florida

    St. Petersburg, Florida, 33711, United States

  • Retinal Consultants of San Antonio

    San Antonio, Texas, 78240, United States

  • Retinal Research Institute (retina consultants of AZ)

    Phoenix, Arizona, 85053, United States

  • Sheffield Teaching Hospitals NHS Foundation Trust

    Sheffield, S10 2SB, United Kingdom

  • Sierra Eye Associates

    Reno, Nevada, 89502, United States

  • Southeast Retina Center

    Augusta, Georgia, 30909, United States

  • Southeastern Retina Associates, PC

    Knoxville, Tennessee, 37922, United States

  • St. Franziskus-Hospital

    Münster, 48145, Germany

  • St.Paul's Eye Unit

    Liverpool, L7 8XP, United Kingdom

  • Stichting Radboud Universitair Medisch Centrum

    Nijmegen, 6525 GA, Netherlands

  • Sunderland Eye Infirmary

    Sunderland, SR2 9HP, United Kingdom

  • Sydney Hospital and Sydney Eye Hospital

    Sydney, 2000, Australia

  • Texas Retina Associates

    Dallas, Texas, 75231, United States

  • The Retina Care Center

    Baltimore, Maryland, 21209, United States

  • The Retina Clinic London

    London, W1G 7LB, United Kingdom

  • The University of Melbourne - The Centre for Eye Research Australia (CERA)

    Melbourne E., Victoria, Australia

  • Universitaetsklinikum Bonn

    Bonn, 53127, Germany

  • Universitaetsklinikum Schleswig-Holstein Campus Lübeck

    Lübeck, Schleswig-Holstein, 23538, Germany

  • Universitatsklinikum Tübingen

    Tübingen, 72076, Germany

  • University Retina Macula Associates PC

    Lemont, Illinois, 60439, United States

  • Vision Research Center Eye Associates of New Mexico

    Albuquerque, New Mexico, 87109, United States

  • VitreoRetinal Associates, P.A.

    Gainesville, Florida, 32607, United States

  • VitreoRetinal Surgery, PLLC

    Minneapolis, Minnesota, 55435, United States

  • West Virginia University

    Morgantown, West Virginia, 26506, United States

  • Wolfe Eye Clinic

    West Des Moines, Iowa, 50266, United States

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