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Video game training put to the test for MS brain fog

NCT ID NCT07086950

Symptom relief Sponsor: Prof. Arseny Sokolov, MD, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 05, 2026 · Last updated Oct 06, 2026 · Updated 1 time

Summary

Many people with multiple sclerosis develop problems with memory, attention, and thinking speed that affect daily life. Researchers are testing a medical device called Body Brain Trainer, which uses playful video game exercises that combine physical and mental challenges. In this trial, 190 adults with relapsing or secondary progressive MS and mild cognitive difficulties will use either the exergame or a standard computer training program for four weeks. The goal is to see which approach does more to reduce perceived cognitive problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Body Brain Trainer, an adaptive cognitive exergame combining physical and mental exercises
What this could lead to
If the exergame works better than standard computer training, it could offer a more engaging way to help people with multiple sclerosis manage thinking problems.
What could go wrong
This is a single trial with 190 participants, and cognitive training studies often show small or short-lived benefits. The exergame may not outperform standard training, and any gains might fade after the four-week program ends.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 190 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Informed Consent signed by the participant, 2. Adults 18+ years, 3. Patients with a diagnosis of relapsing multiple sclerosis according to the most recent internationally recognized criteria, as evaluated by their treating physicians (Thompson et al., 2018) or secondary progressive MS (diagnosis ≤ 30 months), 4. Presence of cognitive complaint, 5. Z-Score ≤ -0.5 in the Symbol Digit Modalities Test (SDMT) Exclusion criteria: 1. Clinically or radiologically confirmed MS relapses within 3 months prior to enrollment, 2. Change in disease modifying treatments (DMT), antidepressant or anxiolytic medication within 1 month prior to enrollment, 3. High risk of falls based on a completion time of more than 15 seconds in the Four Square Step Test (FSST) (Dite \& Temple, 2002), 4. Assisted locomotion or falls in the past 3 months as evaluated in the enrollment interview (Hopkins Falls Grading Scale (Grade \> 1)), 5. Major psychiatric and/or neurocognitive disorders according to the DSM-5 (APA, 2013), 6. Incapacity to discriminate colors (Ishihara test; (Clark, 1924)), 7. Insufficient language knowledge to understand instructions or questionnaires, 8. High-risk pregnancy as evaluated by the appointed gynecologist. 9. Z-Score ≤ -3.5 in the Symbol Digit Modalities Test (SDMT).

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis Neurorehabilitation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Service universitaire de neuroréhabilitation

    RECRUITING

    Lausanne, Canton of Vaud, 1011, Switzerland

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