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Can a treadmill test predict a Child's heart rate at play?

NCT ID NCT06661278

Knowledge-focused Sponsor: Royal Brompton & Harefield NHS Foundation Trust Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This study looks at children and adolescents aged 6 to 16 with inherited arrhythmias, such as long QT syndrome, to see if a controlled exercise test on a treadmill reflects their actual heart rate and activity levels during daily life. Participants will complete a routine exercise test, then wear a heart rate and activity monitor for two weeks while keeping a diary of their activities. The researchers will also check how accurately children and parents recall physical activity compared to what the monitors record. The goal is to improve how doctors use exercise tests to guide medication dosing and exercise advice for these young patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise tolerance test and physical activity monitoring
What this could lead to
If it works, this could improve how doctors prescribe exercise and adjust heart medications for children with inherited arrhythmias, making daily activity safer and more tailored.
What could go wrong
This is an observational study with a small number of participants, so results may not apply to all children. The measures are exploratory, and the study does not test a treatment, so it may not change practice directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

55 people

The number who actually took part.

Started

Mar 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Affected cohort: 60 children aged 6-16 years, diagnosed with inherited arrhythmias (IAS) Unaffected cohort: 50 healthy children aged 6-16 years (siblings of affected children and those undergoing screening for inherited arrhythmias)

Ages

6 to 16 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Affected cohort * Male and female children * Aged 6-16 years * Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia * Treated with beta-blocker and/or sodium channel blockade * Able to complete a treadmill ETT Healthy cohort * Male and female children * Aged 6-16 years * Siblings of affected children (gene negative) * Undergoing IAS screening * Able to complete a treadmill ETT Exclusion Criteria: * Children aged less than 6 years * Adults, 17 years of age and above * Unable to run on an exercise treadmill due to physical limitations. * Individuals unable to speak or understand English, due to no translation service available. * Pregnancy

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Conditions

The condition(s) this trial relates to.

catecholaminergic polymorphic ventricular tachycardia 1 catecholaminergic polymorphic ventricular tachycardia 2 long QT syndrome Motor Activity Polymorphic Catecholaminergic Ventricular Tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Catecholaminergic polymorphic ventricular tachycardia type 1 Catecholaminergic polymorphic ventricular tachycardia type 2 Long QT syndrome

Contacts and locations

Locations

  • Great Ormond Street Hospital

    London, WC1N 3JH, United Kingdom

  • Royal Brompton Hospital

    Sutton, SW36NP, United Kingdom

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