Pedaling through chemo: could exercise boost tumor blood flow?
NCT ID NCT07785882
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This trial tests whether doing light-to-moderate aerobic exercise during chemotherapy infusions is safe and practical for people with sarcoma (a type of cancer). Participants will exercise in 15-minute intervals during each infusion, and researchers will also check if exercise temporarily increases blood flow to tumors, which might help chemo work better. The study compares side effects and quality of life against historical data from similar patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- moderate-intensity aerobic exercise performed during chemotherapy infusion
- What this could lead to
- If safe and feasible, this approach could become a standard way to improve quality of life and potentially enhance chemotherapy effectiveness by increasing tumor blood flow.
- What could go wrong
- This is a small early-stage trial with only 16 participants, so results may not apply broadly. Exercise during infusion could pose risks like cardiac strain or muscle damage, which the study will monitor.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 16 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Initiating at least two series of chemotherapy for non-resected sarcoma at Clinic 6, Herlev Hospital, Denmark * Eastern Cooperative Oncology Group performance status of 0-2 * No mental or physical disabilities precluding exercise * Approval by the treating oncologist * Able to read Danish * Willing to sign informed consent Exclusion Criteria: * Home-based chemotherapy * Infusions lasting under one hour * Elevated risk for developing cardiac issues (left ventricular ejection fraction ≤50%) based on routine echocardiography
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Oncology, Herlev Hospital
Herlev, Region Sjælland, 2730, Denmark
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can repeated MRI scans reveal how tumors respond to radiation?
- Can a new antibody help the immune system fight Hard-to-Treat tumors?
- Can a structured recovery plan speed healing after sarcoma surgery?
- Can a One-Two punch of immunotherapy and radiation tame sarcoma before surgery?