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Can walking flush out hidden toxins? new study tests exercise against PFAS

NCT ID NCT07706465

Knowledge-focused Sponsor: Poznan University of Physical Education Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study investigates whether different types of exercise can help middle-aged women reduce their body burden of PFAS (environmental chemicals) and improve muscle function. Participants will be assigned to either interval walking or high-intensity circuit training for six months, with follow-up assessments. The research also includes a group of breast cancer survivors to see how past cancer treatment affects these responses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
interval walking training and high-intensity circuit training
What this could lead to
If successful, this could reveal how different exercise programs help eliminate environmental toxins and improve health in middle-aged women.
What could go wrong
This is an observational and interventional study with exploratory outcomes; results may not show clear benefits or apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 75 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (HICT, IWT and Control groups): * Women, * aged 35-75 years * qualified by a physician for participation in the study and with no contraindications to the training intervention (e.g., heart failure, asthma, chronic obstructive pulmonary disease \[COPD\], or arthritis) Inclusion Criteria (Onco Group): * Women , * aged 35-75 years, * Diagnosed with invasive breast cancer, Stage I-III disease according to the TNM classification, * Estrogen receptor-positive (ER+) breast cancer, defined as expression in at least 10% of tumor cell nuclei, * Adjuvant hormone therapy with an aromatase inhibitor for at least 6 months, * BMI between 18.5 and 32 kg/m². * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. * No chronic diseases limiting the possibility of oncological treatment. * No contraindications to daily physical activity. * Willingness to maintain a daily step count of 8,000 steps. Exclusion Criteria (HICT, IWT and Control groups): * history of cardiovascular disease, * previous hospitalization for cardiovascular conditions, * ongoing cardiovascular treatment, or recent cardiovascular symptoms, * advanced osteoporosis Exclusion Criteria (Onco Group): * Stage IV invasive breast cancer according to the TNM classification. * ECOG performance status ≥2. * Unstable ischemic heart disease. * Cardiac arrhythmias. * Advanced degenerative joint disease. * Rheumatic disorders (including rheumatoid arthritis, osteoarthritis, or fibromyalgia). * Progression of chronic diseases. * Pregnancy. * BMI \<18.5 or \>32 kg/m². * Uncontrolled hypothyroidism or hyperthyroidism.

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Conditions

The condition(s) this trial relates to.

cancer invasive breast carcinoma Motor Activity neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthly volunteers Oncologic disease

How to take part

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  1. The official record

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