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Can exercise and fasting fire up brown fat in older women?

NCT ID NCT07837752

Knowledge-focused Sponsor: Universidad de Almeria Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 23, 2026 · Last updated Sep 24, 2026 · Updated 1 time

Summary

Researchers are investigating whether aerobic exercise, a five-day prolonged fasting protocol, or a combination of both can improve the function of brown fat (interscapular brown adipose tissue) and overall metabolic flexibility in postmenopausal women with overweight or obesity. Sixty women aged 45 to 65 will be randomly assigned to one of four groups: control, exercise, fasting, or both. The study will measure changes in brown fat mitochondrial function and metabolic health before, immediately after, and four weeks after the interventions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aerobic exercise and prolonged fasting
What this could lead to
If the interventions work, they could offer a lifestyle-based way to improve brown fat activity and metabolic health in postmenopausal women, potentially lowering the risk of cardiometabolic diseases.
What could go wrong
This is an early, small study with 60 participants, so any benefits may not be large or lasting. The interventions require significant time and commitment, and the biopsy procedure carries minor risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2027

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 45 to 65 years. * Postmenopausal status, defined as ≥ 12 consecutive months without menstruation. * Women with amenorrhea shorter than 12 months will be included if their follicle-stimulating hormone levels are \>30IU/liter. * BMI between ≥25 kg/m2. * Sedentary or low-active (not meeting physical activity guidelines). * Willing to be randomized to any of the four groups. * Able and willing to adhere to all study procedures and show availabity in their schedule. * Must be willing to have biological samples stored for future research. Exclusion Criteria: * Diabetes mellitus (determined based on fasting glucose levels defined by ADA criteria). * Any other active endocrine disease (thyroid disease, any signs of Cushing's syndrome, adrenal disease and lipid-associated disorders such as familial hypercholesterolemia). * Any cardiac disease (i.e., ischemic cardiac disease, arrhythmias, severe heart failure). * Use of medication known to influence glucose and/or lipid metabolism or brown fat activity (e.g., beta-blockers, antidepressants, corticosteroids). * Current or recent (past 6 months) use of hormone replacement therapy, including systemic estrogen therapy (oral or transdermal), combined estrogen-progestin therapy, tibolone, or selective estrogen receptor modulators. * Clinically relevant abnormalities in clinical chemistry or electrocardiogram at screening (to be judged by the study physician). * A first-degree family member with sudden cardiac death. * Any chronic renal or hepatic disease. * Abuse of alcohol or other substances.

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Conditions

The condition(s) this trial relates to.

Fasting Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiometabolic diseases Postmenopause

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Universidad de Almería

    Almería, Almería, 04131, Spain

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