New hope for mesothelioma patients: experimental combo enters final testing

NCT ID NCT06097728

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called volrustomig combined with chemotherapy against standard treatments for people with advanced pleural mesothelioma that cannot be removed by surgery. About 861 adults with this rare lung cancer will be randomly assigned to receive either the experimental combo or one of two standard therapies. The main goal is to see if the new combination helps people live longer.

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Conditions

The condition(s) this trial relates to.

malignant pleural mesothelioma mesothelioma Mesothelioma, Malignant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UNRESECTABLE PLEURAL MESOTHELIOMA

Contacts and locations

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Locations

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Santa Rosa, California, 95403, United States
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Aurora, Colorado, 80045, United States
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Jacksonville, Florida, 32224, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60637, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Commack, New York, 11725, United States
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Columbus, Ohio, 43210, United States
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Portland, Oregon, 97213, United States
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Portland, Oregon, 97225, United States
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Philadelphia, Pennsylvania, 19104, United States
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Houston, Texas, 77030, United States
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Fairfax, Virginia, 22031, United States
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Chermside, 4032, Australia
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Clayton, 3168, Australia
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Melbourne, 3000, Australia
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Nedlands, 6009, Australia
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Westmead, 2145, Australia
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Anderlecht, 1070, Belgium
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Antwerp, 2020, Belgium
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Ghent, 9000, Belgium
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Hasselt, 3500, Belgium
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Sint-Niklaas, 9100, Belgium
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Barretos, 14784-400, Brazil
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Fortaleza, 60336-045, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 22281-100, Brazil
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Santo André, 09060-650, Brazil
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São Paulo, 01246-000, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Montreal, Quebec, H2X 0C1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Beijing, 100142, China
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Beijing, 100210, China
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Changsha, 410013, China
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Chengdu, 610042, China
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Guangzhou, 510100, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Kunming, 650118, China
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Lanzhou, 730000, China
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Ningbo, 315100, China
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Qingdao, 266003, China
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Shandong, China
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Shanghai, 200032, China
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Shenyang, 110044, China
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Taiyuan, 030000, China
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Taiyuan, 030032, China
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Tianjin, 300050, China
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Tianjin, 300060, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China
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Aarhus N, 8200, Denmark
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Copenhagen, 2100, Denmark
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Brest, 29200, France
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Créteil, 94010, France
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Le Mans, 72037, France
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Lille, 59037, France
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Lyon, 69373, France
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Marseille, 13015, France
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Montpellier, 34298, France
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Paris, 75877, France
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Rouen, 76031, France
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Saint-Herblain, 44800, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Berlin, 13125, Germany
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Berlin, 14109, Germany
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Bochum, 44791, Germany
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Cologne, 51109, Germany
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Essen, 45122, Germany
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Gauting, 82131, Germany
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Georgsmarienhütte, 49124, Germany
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Großhansdorf, 22927, Germany
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Hamburg, 21075, Germany
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Heidelberg, 69126, Germany
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Kiel, 24105, Germany
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Münster, 48153, Germany
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Regensburg, 93049, Germany
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Alessandria, 15100, Italy
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Bari, 70124, Italy
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Bergamo, 24125, Italy
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Milan, 20141, Italy
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Monza, 20052, Italy
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Orbassano, 10043, Italy
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Padova, 35128, Italy
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Parma, 43100, Italy
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Rozzano, 20089, Italy
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Varese, 21100, Italy
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Amagasaki-shi, 660-8550, Japan
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Hakodate-shi, 040-8611, Japan
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Hiroshima, 734-8551, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kitakyushu-shi, 807-8555, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 466-8560, Japan
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Nishinomiya-shi, 663-8501, Japan
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Okayama, 702-8055, Japan
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Osakasayama-shi, 589-8511, Japan
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Tokyo, 104-0045, Japan
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Ube-shi, 755-0241, Japan
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Amsterdam, 1066CX, Netherlands
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Eindhoven, 5623EJ, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Lørenskog, 1478, Norway
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Oslo, 450, Norway
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Bystra, 43-360, Poland
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Olsztyn, 10-357, Poland
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Poznan, 60-569, Poland
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Warsaw, 02-781, Poland
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Cape Town, 7570, South Africa
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eManzimtoti, 4126, South Africa
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Johannesburg, 2013, South Africa
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Johannesburg, 2193, South Africa
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Kimberly, 8301, South Africa
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Pretoria, 0002, South Africa
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Pretoria, 0081, South Africa
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Seoul, 03080, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barakaldo, 48903, Spain
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Barcelona, 8035, Spain
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Madrid, 28041, Spain
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Oviedo, 33011, Spain
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Baden, CH-5405, Switzerland
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Basel, 4031, Switzerland
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Bern, 3010, Switzerland
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Fribourg, 1700, Switzerland
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Sankt Gallen, 9007, Switzerland
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Kaohsiung City, 80756, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 10002, Taiwan
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Ankara, 06280, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Izmir, 35110, Turkey (Türkiye)
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Cambridge, CB20QQ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Leicester, LE1 5WW, United Kingdom
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London, NW1 2PG, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M23 9LT, United Kingdom
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Newcastle upon Tyne, NE2 4HH, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
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Taunton, TA1 5DA, United Kingdom