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Could a cool eye zap away chronic pain?

NCT ID NCT07059754

Symptom relief Sponsor: EyeCool Therapeutics, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small study tests a device that cools the eye surface to see if it helps people with chronic eye pain. Five participants will get a single 4-minute cold treatment and be followed for 12 weeks. Researchers will take pictures of the eye's nerves and collect tear samples to look for changes in inflammation and structure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ETX-4143 topical ophthalmic cooling device
What this could lead to
If it works, this could point toward a non-drug way to ease chronic eye pain by cooling the eye surface.
What could go wrong
This is a very early, tiny study with only 5 people. It is designed to see if the device is safe and worth studying further, not to prove it works. The results may not apply to everyone with eye pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 5 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Documented symptoms of COSP pain for at least 3 months * A score of ≥5 on the single question COP-Q Eye Pain Severity Module * Able to obtain sufficient quality corneal in-vivo confocal microscopy images Exclusion Criteria: * Less than 50% improvement in VAS Eye Pain score after topical 0.5% proparacaine hydrochloride at screening * Subjects with clinically significant corneal scarring that could limit the confocal microscopy * Insufficient number of corneal nerves to permit Fun-IVCM imaging

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Conditions

The condition(s) this trial relates to.

Eye Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Eye pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sunshine Eye Surgeons

    RECRUITING

    Melbourne, Victoria, 3021, Australia

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