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New combo therapy targets Hard-to-Treat myeloma

NCT ID NCT05259839

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This early-stage study tests a new drug called etentamig combined with standard treatments for people with multiple myeloma that has come back or stopped responding to therapy. About 320 adults will take part to find the safest dose and check for side effects. The goal is to control the disease, not cure it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY MULTIPLE MYELOMA

Contacts and locations

Locations

  • Atrium Health Levine Cancer Institute /ID# 242851

    Charlotte, North Carolina, 28204, United States

  • CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 244145

    Madrid, 28027, Spain

  • Calvary Mater Newcastle /ID# 243730

    Waratah, New South Wales, 2298, Australia

  • Clinica Universidad de Navarra - Pamplona /ID# 242977

    Pamplona, Navarre, 31008, Spain

  • Dana-Farber Cancer Institute /ID# 249529

    Boston, Massachusetts, 02215, United States

  • Epworth Healthcare /ID# 243734

    Richmond, Victoria, 3121, Australia

  • Fiona Stanley Hospital /ID# 244753

    Murdoch, Western Australia, 6150, Australia

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 244057

    Milan, 20122, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 242582

    Rome, Roma, 00168, Italy

  • Froedtert Memorial Lutheran Hospital /ID# 242654

    Milwaukee, Wisconsin, 53226-3522, United States

  • Hokkaido University Hospital /ID# 245966

    Sapporo, Hokkaido, 060-8648, Japan

  • Hospital Clinic de Barcelona /ID# 242978

    Barcelona, 08036, Spain

  • Hospital Duran i Reynals /ID# 242979

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Hospital Universitario 12 de Octubre /ID# 242975

    Madrid, 28041, Spain

  • Hospital Universitario Vall de Hebron /ID# 242976

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen del Rocio /ID# 242974

    Seville, 41013, Spain

  • Huntsman Cancer Institute /ID# 242872

    Salt Lake City, Utah, 84112-5500, United States

  • IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 242581

    Bologna, 40138, Italy

  • IRCCS Ospedale San Raffaele /ID# 242583

    Milan, Milano, 20132, Italy

  • Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 242584

    Meldola, Forlì-Cesena, 47014, Italy

  • Kanazawa University Hospital /ID# 246812

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Memorial Sloan Kettering Cancer Center /ID# 244656

    New York, New York, 10065-6007, United States

  • Moffitt Cancer Center /ID# 243437

    Tampa, Florida, 33612-9416, United States

  • Monash Health - Monash Medical Centre - Clayton /ID# 244403

    Clayton, Victoria, 3168, Australia

  • Nagoya City University Hospital /ID# 249094

    Nagoya, Aichi-ken, 467-8602, Japan

  • National Cancer Center Hospital East /ID# 245889

    Kashiwa-shi, Chiba, 277-8577, Japan

  • Okayama Medical Center /ID# 245882

    Okayama, Okayama-ken, 701-1192, Japan

  • Peter MacCallum Cancer Ctr /ID# 256880

    Melbourne, Victoria, 3000, Australia

  • Rutenberg Cancer Center /ID# 244647

    New York, New York, 10029-6030, United States

  • St George Hospital - Kogarah /ID# 243740

    Kogarah, New South Wales, 2217, Australia

  • St Vincent's Hospital Melbourne /ID# 256879

    Fitzroy Melbourne, Victoria, 3065, Australia

  • Sylvester Comprehensive Cancer Center /ID# 243673

    Miami, Florida, 33136-1002, United States

  • Szpital Wojewodzki w Opolu sp. z o.o. /ID# 243954

    Opole, Lower Silesian Voivodeship, 45-372, Poland

  • The Valley Hospital /ID# 243829

    Paramus, New Jersey, 07652, United States

  • Universitaetsklinikum Essen /ID# 242819

    Essen, 45147, Germany

  • Universitaetsklinikum Hamburg-Eppendorf /ID# 243141

    Hamburg, 20246, Germany

  • Universitaetsklinikum Regensburg /ID# 242837

    Regensburg, Bavaria, 93042, Germany

  • Universitaetsklinikum Tuebingen /ID# 242815

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitaetsklinikum Wuerzburg /ID# 242826

    Würzburg, Bavaria, 97080, Germany

  • University of Arkansas for Medical Sciences /ID# 243096

    Little Rock, Arkansas, 72205, United States

  • University of Maryland, Baltimore /ID# 243679

    Baltimore, Maryland, 21201, United States

  • University of Massachusetts - Worcester /ID# 243977

    Worcester, Massachusetts, 01655, United States

  • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 243438

    Ann Arbor, Michigan, 48109, United States

  • University of Texas - Southwestern Medical Center /ID# 243273

    Dallas, Texas, 75235, United States

  • University of Washington /ID# 243172

    Seattle, Washington, 98109, United States

  • Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 243500

    Lublin, Lublin Voivodeship, 20-081, Poland

  • Uniwersytecki Szpital Kliniczny We Wroclawiu /ID# 243246

    Wroclaw, Lower Silesian Voivodeship, 50-556, Poland

  • Uniwersyteckie Centrum Kliniczne /ID# 243249

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Yamagata University Hospital /ID# 245888

    Yamagata, Yamagata, 990-9585, Japan

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