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New drug targets rare protein disease in early trial

NCT ID NCT06158854

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests an experimental drug called etentamig (ABBV-383) in adults with AL amyloidosis, a rare disease where abnormal proteins build up in organs. About 76 participants will receive the drug by infusion to see if it is safe and can control the disease. The trial has two parts to find the best dose and measure response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Etentamig (ABBV-383)

What this could lead to

If it works, this could provide a new treatment option to control AL amyloidosis by reducing harmful protein buildup.

What could go wrong

This is an early-phase trial with small numbers, so results may not apply broadly. Side effects are unknown and could be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

AL amyloidosis amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNOGLOBULIN LIGHT CHAIN (AL) AMYLOIDOSIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Alexandra General Hospital /ID# 255542

    RECRUITING

    Athens, Attica, 11528, Greece

  • Atrium Health Levine Cancer Institute /ID# 255074

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Atrium Health Wake Forest Baptist Medical Center /ID# 255851

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • Boston Medical Center /ID# 255066

    RECRUITING

    Boston, Massachusetts, 02118, United States

  • Box Hill Hospital /ID# 255199

    RECRUITING

    Box Hill, Victoria, 3128, Australia

  • CHU Limoges - Dupuytren 1 /ID# 255370

    RECRUITING

    Limoges, Franche-Comte, 87042, France

  • CHU Toulouse - Hopital Rangueil /ID# 255377

    RECRUITING

    Toulouse, Haute-Garonne, 31400, France

  • Columbia University Medical Center /ID# 255068

    RECRUITING

    New York, New York, 10032-3729, United States

  • Fondazione IRCCS Policlinico San Matteo /ID# 255655

    RECRUITING

    Pavia, 27100, Italy

  • IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 255654

    RECRUITING

    Bologna, 40138, Italy

  • Icahn School of Medicine at Mount Sinai /ID# 255408

    RECRUITING

    New York, New York, 10029, United States

  • Japanese Red Cross Medical Center /ID# 256083

    RECRUITING

    Shibuya-ku, Tokyo, 150-8935, Japan

  • Kumamoto University Hospital /ID# 262579

    RECRUITING

    Kumamoto, Kumamoto, 8608556, Japan

    Contact Phone: •••-•••-••••

  • Mayo Clinic - Rochester /ID# 255258

    RECRUITING

    Rochester, Minnesota, 55905-0001, United States

  • Memorial Sloan Kettering Cancer Center-Koch Center /ID# 255073

    RECRUITING

    New York, New York, 10065-6007, United States

  • Nagoya City University Hospital /ID# 256086

    RECRUITING

    Nagoya, Aichi-ken, 467-8602, Japan

  • Oregon Medical Research Center /ID# 255119

    RECRUITING

    Portland, Oregon, 97239, United States

  • Princess Alexandra Hospital /ID# 255202

    RECRUITING

    Woolloongabba, Queensland, 4102, Australia

  • Sylvester Comprehensive Cancer Center - University of Miami /ID# 255856

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Washington /ID# 261581

    RECRUITING

    Seattle, Washington, 98109, United States

  • Vanderbilt University Medical Center. /ID# 273510

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Westmead Hospital /ID# 255200

    RECRUITING

    Westmead, New South Wales, 2145, Australia

  • Wisconsin Medical Center /ID# 255836

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States