New vaccine shows promise against Travelers' diarrhea in early trial

NCT ID NCT06692907

First seen Nov 01, 2025 · Last updated May 11, 2026 · Updated 30 times

Summary

This study tested an experimental vaccine (CssBA+dmLT) to prevent moderate-to-severe diarrhea caused by ETEC bacteria, a common cause of travelers' diarrhea. 72 healthy adults received either the vaccine or a placebo, then were intentionally exposed to the bacteria in a controlled setting. The goal was to see if the vaccine could reduce severe diarrhea and check for side effects.

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Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center Vaccine Research Center

    Cincinnati, Ohio, 45229-3039, United States

  • University of Maryland, School of Medicine, Center for Vaccine Development and Global Health

    Baltimore, Maryland, 21201-1509, United States

Conditions

Explore the condition pages connected to this study.