New oral vaccine against e. coli diarrhea passes first safety check

NCT ID NCT01147445

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 28 times

Summary

This early-stage study tested a new oral vaccine (dmLT) to see if it is safe for people. The vaccine aims to protect against a type of E. coli that causes diarrhea, often called traveler's diarrhea. About 36 healthy adults aged 18-45 received one of four vaccine doses and were monitored for side effects and immune response over 8 months.

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Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center - Gastroenterology, Hepatology and Nutrition

    Cincinnati, Ohio, 45229-3026, United States

  • University of Maryland, School of Medicine, Center for Vaccine Development and Global Health

    Baltimore, Maryland, 21201-1509, United States

Conditions

Explore the condition pages connected to this study.