New shot tested to break vicious cycle of migraines and painkiller overuse

NCT ID NCT03971071

Completed Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

Summary

This study tested whether a monthly injection called erenumab could help adults with very frequent chronic migraines who also overuse headache medications. The goal was to see if the treatment could reduce both the number of headache days and the need for daily painkillers. About 620 people who had not found success with other preventive treatments participated in this late-stage trial.

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Contacts and locations

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Locations

Allegheny Health Network Cancer Institute at Mellon Pavilion

Pittsburgh, Pennsylvania, 15224, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Axiom Research

Colton, California, 92324, United States
Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

Palermo, 90127, Italy
Azienda Ospedaliero Universitaria Mater Domini

Catanzaro, 88100, Italy
Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz

Miskolc, 3526, Hungary
Campus Neurologico Senior

Torres Vedras, 2560-280, Portugal
Centre Hospitalier Annecy Genevois

Pringy, 74374, France
Centre Hospitalier Regional Universitaire de Lille - Hopital Roger Salengro

Lille, 59037, France
Centre Hospitalier Universitaire Saint-Etienne - Hopital Nord

Saint-Etienne, 42055, France
Centre Hospitalier Universitaire de Nice - Hopital de Cimiez

Nice, 06003, France
Centre Hospitalier Universitaire de Poitiers

Poitiers, 86021, France
Centro Hospitalar de Lisboa Norte, EPE - Hospital de Santa Maria

Lisbon, 1649-035, Portugal
Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Spolka Jawna

Ksawerów, 95-054, Poland
Citizens Memorial Healthcare

Bolivar, Missouri, 65613, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clinical Neuroscience Solutions

Orlando, Florida, 32801, United States
Clinical Research Center Spzoo Medic-R Spolka Komandytowa

Poznan, 60-848, Poland
Clinical Research Institute

Los Angeles, California, 90048, United States
Clinical Research Institute Inc

Minneapolis, Minnesota, 55402, United States
Clinical Trial Investigator Clinical Research Center

Cincinnati, Ohio, 45212, United States
Collective Medical Research

Prairie Village, Kansas, 66208, United States
College Park Family Care Center

Overland Park, Kansas, 66212, United States
Core Healthcare Group

Cerritos, California, 90703, United States
Dado Medical sro

Prague, 120 00, Czechia
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz

Debrecen, 4026, Hungary
DelRicht Research

New Orleans, Louisiana, 70124, United States
Dent Neurosciences Research Center

Amherst, New York, 14226, United States
Emerald Coast Center for Neurological Disorders

Pensacola, Florida, 32504, United States
Fakultni nemocnice u svate Anny v Brne

Brno, 656 91, Czechia
Floridian Clinical Research LLC

Miami Lakes, Florida, 33016, United States
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Fondazione Istituto Neurologico Nazionale C Mondino IRCCS

Pavia, 27100, Italy
Fort Wayne Neurological Center

Fort Wayne, Indiana, 46804, United States
Gabinet Lekarski Jacek Rozniecki

Lodz, 90-338, Poland
Groupe hospitalier Paris Saint Joseph

Paris, 75014, France
Helsingin Paansarkykeskus Aava

Helsinki, 00930, Finland
Holdsworth House Medical Practice

Sydney, New South Wales, 2010, Australia
Hopital La Timone

Marseille, 13385, France
Hopital Lariboisiere

Paris, 75010, France
Hospices Civils de Lyon - Hopital neurologique Pierre Wertheimer

Bron, 69677, France
Hospital Clinico Universitario Lozano Blesa

Zaragoza, Aragon, 50009, Spain
Hospital Clinico Universitario de Valencia

Valencia, Valencia, 46010, Spain
Hospital Clinico Universitario de Valladolid

Valladolid, Castille and León, 47010, Spain
Hospital Professor Doutor Fernando Fonseca, EPE

Amadora, 2720-276, Portugal
Hospital Universitari Vall d Hebron

Barcelona, Catalonia, 08035, Spain
Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Catalonia, 08907, Spain
Hospital Universitari i Politecnic La Fe

Valencia, Valencia, 46026, Spain
Hospital Universitario Virgen del Rocio

Seville, Andalusia, 41013, Spain
Hospital da Luz, SA

Lisbon, 1500-650, Portugal
Hull Royal Infirmary

Hull, HU3 2JZ, United Kingdom
INEP

Prague, 186 00, Czechia
IRCCS Istituto delle Scienze Neurologiche di Bologna Ospedale Bellaria

Bologna, 40139, Italy
IRCCS San Raffaele Pisana

Roma, 00163, Italy
Jahn Ferenc Del-pesti Korhaz es Rendelointezet

Budapest, 1204, Hungary
Jerzy Petz Mediq Niepubliczny Zaklad Opieki Zdrowotnej

Legionowo, 05-120, Poland
John Radcliffe Hospital

Oxford, OX3 9DU, United Kingdom
Kings College London

London, SE5 9RS, United Kingdom
Klinikum Klagenfurt am Woerthersee

Klagenfurt, 9020, Austria
Konventhospital der Barmherzigen Brueder Linz

Linz, 4021, Austria
Marshall University

Huntington, West Virginia, 25701, United States
Medizinische Universitaet Innsbruck

Innsbruck, 6020, Austria
Mercy Research

St Louis, Missouri, 63141, United States
Michigan Head Pain and Neurological Institute

Ann Arbor, Michigan, 48104, United States
Mudr Stanislav Bartek sro

Přerov, 750 02, Czechia
Nashville Neuroscience Group

Nashville, Tennessee, 37203, United States
Neurologie Brno sro

Brno, 616 00, Czechia
Neurology Center of New England PC

Foxborough, Massachusetts, 02035, United States
Northern Cinical Trial Coordinators

Oulu, 90590, Finland
Obudai Egeszsegugyi Centrum Kft

Budapest, 1036, Hungary
Onsite Clinical Solutions LLC

Charlotte, North Carolina, 28277, United States
Orszagos Mentalis, Ideggyogyaszati es Idegsebeszeti Intezet

Budapest, 1145, Hungary
Preferred Primary Care Physicians, Inc

Pittsburgh, Pennsylvania, 15236, United States
Queen Elizabeth University Hospital

Glasgow, G51 4TF, United Kingdom
RCMed Oddzial Sochaczew

Sochaczew, 96-500, Poland
Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, NE1 4LP, United Kingdom
Saint Lukes Clinic

Meridian, Idaho, 83642, United States
Suomen Terveystalo

Tampere, 33100, Finland
Swiss Premium Egeszsegkozpont

Budapest, 1123, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

Szeged, 6725, Hungary
Terveystalo Pulssi

Turku, 20100, Finland
Texas Neurology, PA

Dallas, Texas, 75214, United States
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The George Washington Medical Faculty Associates

Washington D.C., District of Columbia, 20037, United States
The Walton Centre NHS Foundation Trust

Liverpool, L9 7LJ, United Kingdom
Thomayerova nemocnice

Prague, 140 59, Czechia
Universitaetsklinikum Allgemeines Krankenhaus Wien

Vienna, 1090, Austria
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine

Miami, Florida, 33136, United States
University of South Florida

Tampa, Florida, 33612, United States
Vestra Clinics sro

Rychnov nad Kněžnou, 516 01, Czechia
Wasatch Clinical Research LLC

Salt Lake City, Utah, 84107, United States

Conditions

Explore the condition pages connected to this study.

MIGRAINE HEADACHE