Could erectile dysfunction be an early warning sign for heart disease?
NCT ID NCT07813195
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Researchers at Assiut University are investigating whether the severity of erectile dysfunction mirrors the severity of coronary artery disease in men aged 18 to 50. The study enrolls 120 men who are undergoing coronary angiography for suspected or confirmed heart conditions. Participants complete a sexual health questionnaire, and researchers compare those scores with the anatomical severity of blockages seen on their heart scans. The goal is to understand whether erectile dysfunction could serve as a warning sign for hidden heart disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Selective coronary angiography, an imaging procedure that maps the heart's arteries
- What this could lead to
- If the two conditions track together, erectile dysfunction could become an early warning sign that prompts doctors to check men for hidden heart disease before a heart attack strikes.
- What could go wrong
- This is a small observational study of 120 men at a single center, so it can show a link but cannot prove cause and effect. Angiography carries small risks such as bleeding or reaction to contrast dye.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of male patients aged 18 to 50 years who present with erectile dysfunction secondary to diabetes mellitus or cardiovascular-related etiology, undergoing clinical evaluation and sexual health assessment in an outpatient setting. Participants are drawn from eligible patients presenting for routine or specialized cardiovascular and medical care who meet the predefined age and clinical eligibility criteria. The population excludes individuals with primary psychogenic, endocrinological (excluding diabetes mellitus), or neurogenic erectile dysfunction, as well as those with severe systemic comorbidities including cardiogenic shock, hemodynamically unstable cardiovascular disease, NYHA Class III or IV decompensated heart failure, severe hepatic failure, end-stage renal disease on dialysis, active malignancies, or prior history of pelvic trauma/radical prostatectomy.
- Ages
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18 to 50 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1 - Male patients aged between 18 and 50 years. 2-Patients undergoing primary or diagnostic coronary angiography due to suspected or confirmed acute, chronic coronary syndrome or stable angina. 3-Patients providing written informed consent to participate in the study and discuss sexual health assessments. Exclusion Criteria: 1. Patients presenting with cardiogenic shock, unstable hemodynamics. 2. Primary psychogenic, endocrinological (except diabetes mellitus), or neurogenic erectile dysfunction. 3. Prior history of pelvic surgery, pelvic trauma, or radical prostatectomy. 4. Severe hepatic failure, end-stage renal disease on dialysis, or active malignancies. 5. Decompensated heart failure (NYHA Class III or IV).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.