New laser aims to smooth Crow's feet without surgery
NCT ID NCT07114562
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new laser device called Epicare for treating moderate to severe crow's feet wrinkles around the eyes. Up to 50 adults aged 25-65 will receive one or two laser treatments. Researchers will check if wrinkles improve at least one grade on a standard scale three months after the last treatment, using photos reviewed by independent experts.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Epicare fractional nano-thulium laser device
- What this could lead to
- If it works, this could offer a safe, non-surgical option to reduce crow's feet wrinkles.
- What could go wrong
- This is a small, early-stage study with no comparison group. Results may not apply to all skin types or ages, and the effect may be modest or temporary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female, 25-65 years of age, in general good health. * Seeking a reduction in the appearance of periorbital wrinkles. * Bilateral and approximately symmetrical periorbital wrinkles with a Fitzpatrick Wrinkle Classification Scale (FWCS) score 4-9, as assessed by the treating investigator. * Fitzpatrick skin type I-V. * Able to understand the study requirements and sign an EC/IRB-approved informed consent form prior to any study procedures. * Willing and able to comply with the treatment and follow-up schedule, pre- and post-treatment instructions, and allow standardized photography. * Willing to withhold additional aesthetic therapies to the treatment area (e.g., fillers, resurfacing procedures) for the entire study duration. Exclusion Criteria: * Known bleeding disorder (e.g., thrombocytopenia, thrombasthenia, von Willebrand's disease). * Immunocompromised or immunosuppressed (e.g., AIDS, HIV, or immunosuppressive therapy). * Planned or recent use of anti-platelets, anti-coagulants, thrombolytics, ACE inhibitors, vitamin E, or anti-inflammatory drugs from 1 week prior to 1 month after treatment. * Systemic corticosteroid or anabolic steroid use within 30 days prior to enrollment (standard inhaled/nasal corticosteroids are permitted). * Use of weight loss medications before or during the study. * History of chronic or recurrent infection or inflammation that would preclude participation. * Severe allergies with history of anaphylaxis. * History of malignancy within 5 years prior to enrollment. * Infection, inflammation, or active dermatologic disease in the face. * Pregnant, breastfeeding, or planning pregnancy during the study; women of childbearing potential not using reliable contraception for ≥3 months prior and throughout the study. * Exposure to an investigational drug or device within 3 months prior to enrollment or during the study. * Prior permanent facial injections (e.g., silicone, grafting) or any upper-face surgery. * Neurotoxin treatments in the upper face within 6 months prior to enrollment. * Semi-permanent filler (e.g., collagen, CaHA) or any dermal filler (e.g., hyaluronic acid) in the upper face within 18 months prior to enrollment. * Any active or passive implant in the treatment area (metallic, silicone, electronic, or injected chemical substance). * Initiation of over-the-counter anti-wrinkle products (e.g., alpha-hydroxy acids) or prescription treatments (e.g., Retin-A, micro-dermabrasion, chemical peels) within 4 weeks prior to enrollment or planned use during the study. * Occupations involving continuous or routine sun exposure (e.g., lifeguards, outdoor workers). * History of smoking within the past 5 years. * Planned bariatric surgery or recent drastic weight loss. * Unstable body weight during the study. * Any other medical condition, laboratory abnormality, or investigator judgment that could affect compliance, safety, or data integrity.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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