New laser aims to smooth Crow's feet without surgery

NCT ID NCT07114562

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new laser device called Epicare for treating moderate to severe crow's feet wrinkles around the eyes. Up to 50 adults aged 25-65 will receive one or two laser treatments. Researchers will check if wrinkles improve at least one grade on a standard scale three months after the last treatment, using photos reviewed by independent experts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epicare fractional nano-thulium laser device
What this could lead to
If it works, this could offer a safe, non-surgical option to reduce crow's feet wrinkles.
What could go wrong
This is a small, early-stage study with no comparison group. Results may not apply to all skin types or ages, and the effect may be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female, 25-65 years of age, in general good health. * Seeking a reduction in the appearance of periorbital wrinkles. * Bilateral and approximately symmetrical periorbital wrinkles with a Fitzpatrick Wrinkle Classification Scale (FWCS) score 4-9, as assessed by the treating investigator. * Fitzpatrick skin type I-V. * Able to understand the study requirements and sign an EC/IRB-approved informed consent form prior to any study procedures. * Willing and able to comply with the treatment and follow-up schedule, pre- and post-treatment instructions, and allow standardized photography. * Willing to withhold additional aesthetic therapies to the treatment area (e.g., fillers, resurfacing procedures) for the entire study duration. Exclusion Criteria: * Known bleeding disorder (e.g., thrombocytopenia, thrombasthenia, von Willebrand's disease). * Immunocompromised or immunosuppressed (e.g., AIDS, HIV, or immunosuppressive therapy). * Planned or recent use of anti-platelets, anti-coagulants, thrombolytics, ACE inhibitors, vitamin E, or anti-inflammatory drugs from 1 week prior to 1 month after treatment. * Systemic corticosteroid or anabolic steroid use within 30 days prior to enrollment (standard inhaled/nasal corticosteroids are permitted). * Use of weight loss medications before or during the study. * History of chronic or recurrent infection or inflammation that would preclude participation. * Severe allergies with history of anaphylaxis. * History of malignancy within 5 years prior to enrollment. * Infection, inflammation, or active dermatologic disease in the face. * Pregnant, breastfeeding, or planning pregnancy during the study; women of childbearing potential not using reliable contraception for ≥3 months prior and throughout the study. * Exposure to an investigational drug or device within 3 months prior to enrollment or during the study. * Prior permanent facial injections (e.g., silicone, grafting) or any upper-face surgery. * Neurotoxin treatments in the upper face within 6 months prior to enrollment. * Semi-permanent filler (e.g., collagen, CaHA) or any dermal filler (e.g., hyaluronic acid) in the upper face within 18 months prior to enrollment. * Any active or passive implant in the treatment area (metallic, silicone, electronic, or injected chemical substance). * Initiation of over-the-counter anti-wrinkle products (e.g., alpha-hydroxy acids) or prescription treatments (e.g., Retin-A, micro-dermabrasion, chemical peels) within 4 weeks prior to enrollment or planned use during the study. * Occupations involving continuous or routine sun exposure (e.g., lifeguards, outdoor workers). * History of smoking within the past 5 years. * Planned bariatric surgery or recent drastic weight loss. * Unstable body weight during the study. * Any other medical condition, laboratory abnormality, or investigator judgment that could affect compliance, safety, or data integrity.

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As listed by the trial registrant

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How to take part

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