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New hope for elderly lymphoma patients: antibody therapy without harsh chemo

NCT ID NCT05660967

Terminated Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests a drug called epcoritamab, given alone or with another drug (lenalidomide), in elderly patients with a type of lymphoma (DLBCL) who cannot receive standard chemotherapy. The goal is to see how well the treatment shrinks tumors and how safe it is. All 111 participants will receive active treatment, and they have an equal chance of getting epcoritamab alone or the combination.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA

Contacts and locations

Locations

  • AUSL Piacenza Ospedale Guglielmo da Saliceto

    Piacenza, Italy

  • AZ Delta

    Roeselare, Belgium

  • AZ Turnhout - Campus Sint-Elisabeth

    Turnhout, Belgium

  • Asan Medical Center

    Seoul, South Korea

  • Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS

    Bologna, Italy

  • Azienda Ospedaliera Vincenzo Cervello

    Palermo, Italy

  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

    Brescia, Italy

  • Azienda sanitaria integrata università di Trieste

    Trieste, Italy

  • CHU Amiens - Hopital Sud

    Salouël, France

  • CHU Angers - Hôpital Hôtel Dieu

    Angers, France

  • CHU Tours - Hôpital Bretonneau

    Tours, France

  • CHU de Bordeaux - Hôpital Haut-Lévêque

    Pessac, France

  • CHU de Nantes - Hotel Dieu

    Nantes, France

  • Cancer Institute Hospital of JFCR

    Kōtoku, Japan

  • Centrum Medyczne Pratia Poznan

    Skorzewo, Poland

  • Clinica di Ematologia AOU Ospedali Riuniti di Ancona

    Ancona, Ancona, Italy

  • Derriford Hospital

    Plymouth, United Kingdom

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, Czechia

  • Fakultni nemocnice v Motole

    Prague, Czechia

  • Fondazione del Piemonte per l'Oncologia IRCC Candiolo

    Candiolo, Italy

  • Hopital Claude Huriez - CHRU Lille

    Lille, France

  • Hopital de la Conception - APHM

    Marseille, France

  • Hospital Clinic de Barcelona

    Barcelona, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, Spain

  • Hospital San Pedro de Alcantara

    Cáceres, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, Spain

  • Hospital Universitario Nuestra Señora de Valme

    Seville, Spain

  • Hospital Universitario Puerta del Mar

    Seville, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Spain

  • Hôpital Henri Mondor

    Créteil, France

  • Hôpital Saint-Antoine

    Paris, France

  • Hôpital Saint-Louis

    Paris, France

  • ICO Badalona - Hospital Universitari Germans Trias i Pujol

    Badalona, Spain

  • ICO l'Hospitalet - Hospital Duran i Reynals

    Barcelona, Spain

  • IEO Istituto Europeo di Oncologia Parent

    Milan, Italy

  • IRCCS Centro di Riferimento Oncologico

    Aviano, Italy

  • IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - IRST

    Meldola, Italy

  • Institut Jules Bordet

    Anderlecht, Belgium

  • Jeonbuk National University Hospital

    Jeonju, South Korea

  • Kagoshima University Hospital

    Kagoshima, Japan

  • Kanazawa University Hospital

    Kanazawa, Japan

  • Keimyung University Dongsan Hospital

    Daegu, South Korea

  • Kepler Universitätsklinikum

    Linz, Austria

  • Kindai University Hospital

    Ōsaka-sayama, Japan

  • Klinikum Wels-Grieskirchen GmbH

    Wels, Austria

  • Kyushu University Hospital

    Fukuoka, Japan

  • LKH - Universitätsklinikum der PMU Salzburg

    Salzburg, Austria

  • MICS Centrum Medyczne Torun

    Torun, Poland

  • Matsuyama Red Cross Hospital

    Matsuyama, Japan

  • NHO Nagoya Medical Center

    Nagoya, Japan

  • National Cancer Center

    Goyang-si, South Korea

  • National Cancer Center Hospital East

    Kashiwa, Japan

  • Ospedale San Raffaele

    Milan, Italy

  • Pratia MCM Krakow

    Krakow, Poland

  • Royal Cornwall Hospital NHS Trust

    Truro, United Kingdom

  • Royal Marsden Hospital

    Sutton, United Kingdom

  • Royal Marsden Hospital - Fulham

    London, United Kingdom

  • Samsung Medical Center

    Seoul, South Korea

  • Seoul National University Hospital

    Seoul, South Korea

  • Southampton General Hospital

    Southampton, United Kingdom

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin, 53188, United States

  • UZ Brussels

    Jette, Belgium

  • UZ Leuven

    Leuven, Belgium

  • Universitaetsklinikum Aachen AOeR

    Aachen, Germany

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, Baden-Wurttemberg, Germany

  • Universitaetsklinikum Wuerzburg

    Würzburg, Germany

  • Vitaz

    Temse, Belgium

  • Vivantes Klinikum Neukoelln

    Berlin, State of Berlin, Germany

  • Vseobecna fakultni nemocnice v Praze

    Prague, Czechia

  • Wojewodzki Szpital Specjalistyczny w Bialej Podlaskiej

    Biała Podlaska, Poland

  • Yamagata University Hospital

    Yamagata, Japan

  • ZNA

    Antwerp, Belgium

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