New drug combo aims to stop prostate cancer from spreading

NCT ID NCT02446444

Ongoing Disease control Sponsor: University of Sydney Source: ClinicalTrials.gov ↗

First seen May 07, 2026 · Last updated May 07, 2026

Summary

This study tests whether adding enzalutamide to standard hormone therapy and radiation can delay cancer spread or death in men with high-risk localized prostate cancer. About 800 men are taking part. The approach aims to control the disease, not cure it, as ongoing hormone therapy is needed.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AZ Groeninge Kortrijk- Campus Kennedylaan

Kortrijk, 8500, Belgium
Addenbrookes Hospital

Cambridge, United Kingdom
Ashford Cancer Centre Research (Adelaide Cancer Centre)

Kurralta Park, South Australia, 5037, Australia
Auckland City Hospital

Auckland, 1142, New Zealand
Austin Health

Heidelberg, Victoria, 3084, Australia
Beacon Private Hospital

Dublin, Dublin 18, Ireland
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Blacktown Hospital

Blacktown, New South Wales, 2148, Australia
Calvary Mater Newcastle

Waratah, New South Wales, 2298, Australia
Campbelltown Hospital

Campbelltown, New South Wales, 2560, Australia
Charring Cross Hospital: Imperial College Healthcare NHS Trust

London, W6 8RF, United Kingdom
Chris O'Brien Lifehouse

Camperdown, New South Wales, 2050, Australia
Christchurch Hospital

Christchurch, 4170, New Zealand
Cork University Hospital

Cork, Co Cork, Ireland
Dana Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Eastern Health (Box Hill Hospital)

Box Hill, Victoria, 3128, Australia
Epworth HealthCare - Richmond

Richmond, Victoria, 3121, Australia
Fiona Stanley Hospital

Murdoch, Western Australia, 6149, Australia
Flinders Medical Centre

Bedford Park, South Australia, 5042, Australia
Galway University Hospital

Galway, Co Galway, Ireland
Genesis Cancer Care Newcastle

Gateshead, New South Wales, 2290, Australia
Genesis Cancer Care Queensland - Tugun and Southport

Tugun, Queensland, 4224, Australia
Genesis Cancer Care Queensland - Wesley and Chermside

Auchenflower, Queensland, 4066, Australia
Genesis Care - Epping (formerly EROC)

Epping, Victoria, 3076, Australia
Genesis Care - Frankston (formerly FROC)

Frankston, Victoria, 3199, Australia
Genesis Care - Ringwood (formerly RROC)

Ringwood East, Victoria, 3135, Australia
Genesis Care - Western (formerly WROC)

Footscray, Victoria, 3011, Australia
Gosford Hospital

Gosford, New South Wales, 2250, Australia
Guys and St Thomas Hospital

London, SE1 9RT, United Kingdom
Hospital Donostia

Donostia / San Sebastian, Gipuzkoa, 20014, Spain
Hospital Universitario de Salamanca

Salamanca, 37007, Spain
ICON - Gold Coast (formerly ROC Gold Coast)

Southport, Queensland, 4215, Australia
ICON - Toowoomba (formerly ROC Toowoomba)

Toowoomba, Queensland, 4350, Australia
Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)

Badalona, Barcelona, 08916, Spain
Kent and Canterbury Hospital

Canterbury, Kent, CT1 3NG, United Kingdom
Liverpool Hospital

Liverpool, New South Wales, 2170, Australia
Mater Misericordiae University Hospital

Dublin, Dublin 7, Dublin 7, Ireland
Mater Private Hospital

Dublin, Dublin 7, Ireland
Nambour General Hospital

Nambour, Queensland, 4560, Australia
Nottingham City Hospital- City Campus

Nottingham, NG5 1PB, United Kingdom
Orange Health Service

Orange, New South Wales, 2800, Australia
Palmerston North Hospital

Palmerston North, 4442, New Zealand
Peter MacCallum Cancer Centre

Bendigo, Victoria, 3550, Australia
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3002, Australia
Peter MacCallum Cancer Centre (Moorabbin Campus)

Bentleigh East, Victoria, 3165, Australia
Prince of Wales Hospital

Randwick, New South Wales, 2131, Australia
Princess Alexandra Hospital Brisbane

Woolloongabba, Queensland, 4102, Australia
Radiation Oncology Services Mater Centre

South Brisbane, Queensland, 4101, Australia
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Royal Brisbane & Womens Hospital

Herston, Queensland, 4006, Australia
Royal Hobart Hospital

Hobart, Tasmania, 7000, Australia
Royal Marsden Hospital

Chelsea, London, SW3 6JJ, United Kingdom
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
Royal United Hospital Bath

Bath, BA1 3NG, United Kingdom
Salzburger Landeskliniken - Universitätsklinikum Salzburg

Salzburg, 5020, Austria
St George Hospital

Kogarah, New South Wales, 2217, Australia
St Luke's Hospital

Dublin, Dublin 6, Ireland
St Vincent's Hospital

Sydney, New South Wales, 2010, Australia
Sunshine Hospital

St Albans, Victoria, 3021, Australia
Sydney Adventist Hospital

Wahroonga, New South Wales, 2076, Australia
Tamworth Rural Referral Hospital

Tamworth, New South Wales, 2340, Australia
The Institute Of Oncology

Ljubljana, 1000, Slovenia
Townsville Hospital

Douglas, Queensland, 4814, Australia
University Hospital Southhampton

Southampton, Hampshire, SO16 6YD, United Kingdom
University of London Hospital

London, NW1 2BU, United Kingdom
Velindre Hospital

Whitchurch, Cardiff, CF14 2TL, United Kingdom
Western General Hospital

Edinburgh, Scotland, EH4 2XU, United Kingdom
Westmead Hospital

Westmead, New South Wales, 2145, Australia
Wollongong Hospital

Wollongong, New South Wales, 2500, Australia

Conditions

Explore the condition pages connected to this study.

PROSTATIC NEOPLASMS